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Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes.

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First Author : Nie X

Date of Publication : 2017-01-01

Journal : Angew Chem Int Ed Engl

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.56

Issue : No.7

Page Number : 1898-1902

Key Words : aldehydes;cyclization;difluoroalkylation;palladium;radicals

Abstract : A palladium-catalyzed three-component reaction between fluoroalkyl bromides, arylboronic acids, and alkenyl aldehydes has been developed and provides facile access to 5-, 6-, or 7-difluoroalkylated ketones under very mild reaction conditions. The resultan

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