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Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C-H activations.

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First Author : Hu L

Date of Publication : 2016-01-01

Journal : Chem Commun (Camb)

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.52

Issue : No.41

Page Number : 6845-6848

ISSN : 1359-7345

Abstract : A highly mono-selective ortho-trifluoromethylation of benzamides was achieved via Cu-promoted C-H activations. The reaction employs an 8-aminoquinoline group as the bidentate directing group and Togni reagent as the CF 3  source. The reaction tolerated a

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