◆ 个人简介

马广才，博士，浙江师范大学地理与环境科学学院副教授，硕士生导师。目前主要从事新污染物在生物酶中的代谢转化及毒性作用机制研究，先后在J. Am. Chem. Soc., Environ. Sci. Technol., ACS Catal.等国际期刊发表SCI论文30余篇，主持和参与国家自然科学基金及其他省部级项目多项。担任Eco-Environment Health (EEH)期刊青年编委及J. Hazard. Mater., Chemosphere, Chem. Res. Toxicol.等多个国际期刊的审稿人。

◆ 研究简介

(1) 新污染物的代谢转化：基于体外代谢实验和分子模拟相结合的方法研究新污染物(如新型溴代阻燃剂、手性农药)在生物酶(如细胞色素P450酶)中的代谢活性和路径，识别代谢产物，阐明结构和活性的内在联系；

(2) 新污染物及代谢物的毒性作用：基于计算模拟和实验验证深入阐明新污染物及代谢物的毒性效应，如内分泌干扰效应、致癌性等，揭示毒性作用的分子机制。

◆ 工作学习经历

2016.07−至  今，浙江师范大学，地理与环境科学学院环境科学与工程系，讲师、副教授

2011.09−2016.06，山东大学，化学与化工学院，博士

2007.09−2011.06，安徽师范大学，化学与材料科学学院，学士

◆ 科研项目

1. 国家自然科学基金面上项目，“新型溴代阻燃剂的人体代谢转化机制及内分泌激素干扰效应(22176177)”，2022.01-2025.12，主持；

2. 国家自然科学基金青年项目，“烟草特异亚硝胺致癌物在P450 酶中的代谢活化及毒性作用机制研究(21707122)”，2018.01-2020.12，主持；

3. 浙江省基础公益研究计划项目，“新型溴代阻燃剂类污染物的P450 酶代谢机制及性激素干扰效应(LY20B070005)”，2020.01-2022.12，主持

4. 山东省微生物工程重点实验室开放课题，“理性设计提高漆酶热稳定性的研究”，2017.09-2019.09，主持。

◆ 教学项目

1. 浙江省一流本科国际化线下课程，《环境统计与软件应用(Environmental Statistics and Software Application)》，2022，主持；

2. 浙江师范大学一流本科课程重点项目，《环境统计与软件应用》，2022，主持；

3. 浙江师范大学青年教师教学改革项目，“问题式学习教学模式与上机模拟在《环境统计与软件应用》课程中的应用”，2017.01-2018.01，主持

◆ 论文论著 (*标识为通讯作者)

1. Qi Xu, Jian Li, Shang Cao, Guangcai Ma*, Xianglong Zhao, Qiuyi Wang, Xiaoxuan Wei, Haiying Yu*, Zhiguo Wang. Thyroid hormone activities of neutral and anionic hydroxylated polybrominated diphenyl ethers to thyroid receptor β: A molecular dynamics study. Chemosphere, 2023, 311, 136920.

2. Huachang Hong, Yuchen Lu, Xiaoyan Zhu, QiangWu, Lingmin Jin, Zhigang Jin, XiaoxuanWei, Guangcai Ma, Haiying Yu*. Cytotoxicity of nitrogenous disinfection byproducts: A combined experimental and computational study. Science of the Total Environment, 2023, 856, 159273.

3. Cenyang Han, Wenyou Zhu, Guangcai Ma*, Yewen Chen, Xinqi Li, Xiaoxuan Wei, Haiying Yu*. Computational insight into biotransformation of halophenols by cytochrome P450: Mechanism and reactivity for epoxidation. Chemosphere, 2022, 286, 131708.

4. Yue Jia, Tingji Yao, Guangcai Ma*, Qi Xu, Xianglong Zhao, Hui Ding, Xiaoxuan Wei, Haiying Yu*, Zhiguo Wang. Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450. Molecules, 2022, 27, 2799.

5. Qiang Wu, Siqi Cao, Zhenyi Chen, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Predictive Models of Gas/Particulate Partition Coefficients (K_P) for Polycyclic Aromatic Hydrocarbons and Their Oxygen/Nitrogen Derivatives. Molecules, 2022, 27, 7608.

6. Guangcai Ma, Liming Geng, Yuchen Lu, Xiaoxuan Wei, Haiying Yu*. Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1. Chemosphere, 2021, 263, 128353.

7. Miao Li, Jian Li, Yuchen Lu, Cenyang Han, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Developing the QSPR model for predicting the storage lipid/water distribution coefficient of organic compounds. Front. Environ. Sci. Eng. 2021, 15, 24.

8. Guangcai Ma, Haiying Yu,* Cenyang Han, Yue Jia, Xiaoxuan Wei, and Zhiguo Wang*. Binding and Metabolism of Brominated Flame Retardant β‑1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Human Microsomal P450 Enzymes: Insights from Computational Studies. Chem. Res. Toxicol., 2020, 33, 1487−1496.

9. Guangcai Ma, Haiying Yu,* Xiaoqin Xu, Liming Geng, Xiaoxuan Wei, Jiale Wen, and Zhiguo Wang*. Molecular Basis for Metabolic Regioselectivity and Mechanism of Cytochrome P450s toward Carcinogenic 4‑(Methylnitrosamino)-(3-pyridyl)-1-butanone. Chem. Res. Toxicol., 2020, 33, 436−447.

10. Guangcai Ma, Haiying Yu*, Ting Xu, Xiaoxuan Wei, Jianrong Chen, Hongjun Lin, Gerrit Schüürmann. Computational Insight into the Activation Mechanism of Carcinogenic N’-Nitrosonornicotine (NNN) Catalyzed by Cytochrome P450. Environ. Sci. Technol., 2018, 52, 11838−11847.

11. Hao Su, Guangcai Ma, Yongjun Liu. Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes. Inorg. Chem., 2018, 57, 11738−11745.

12. Guangcai Ma, Quan Yuan, Haiying Yu*, Hongjun Lin, Jianrong Chen, Huachang Hong. Development and evaluation of predictive model for bovine serum albumin-water partition coefficients of neutral organic chemicals. Ecotox. Environ. Safe., 2017, 138, 92–97.

13. Guangcai Ma, Wenyou Zhu, Yongjun Liu*. QM/MM studies on the calcium-assisted β-elimination mechanism of pectate lyase from bacillus subtilis. Proteins-structure Function & Bioinformatics, 2016, 84, 1606–1615.

14. Beibei Lin, Guangcai Ma, Liu, Yongjun Liu*. Mechanism of the Glutathione Persulfide Oxidation Process Catalyzed by Ethylmalonic Encephalopathy Protein 1. ACS Catal., 2016, 6, 7010–7020.

15. Guangcai Ma, Wenyou Zhu, Hao Su, Na Cheng, Yongjun Liu*. Uncoupled epimerization and desaturation by carbapenem synthase: mechanistic insights from QM/MM studies. ACS Catal., 2015, 5, 5556–5566.

16. Guangcai Ma, Na Cheng, Hao Su, Yongjun Liu*. Exploring the substrate-assisted acetylation mechanism by UDP-linked sugar N-acetyltransferase from QM/MM calculations: the role of residue Asn84 and the effects of starting geometries. RSC Adv., 2015, 5, 7781–7788.

17. Guangcai Ma, Lihua Dong, Yongjun Liu*. Insights into the catalytic mechanism of dTDP-glucose 4,6-dehydratase from quantum mechanics/molecular mechanics simulations. RSC Adv., 2014, 4, 35449–35458.

18.  Xiaohua Chen*, Guangcai Ma, Weichao Sun, Hongjing Dai, Dong Xiao, Yanfang Zhang, Yongjun Liu*, and Yuxiang Bu. Water promoting electron hole transport between tyrosine and cysteine in proteins via a special mechanism: double proton coupled electron transfer. J. Am. Chem. Soc., 2014, 136, 4515−4524.

19. Guangcai Ma, and Yongjun Liu*. The reaction mechanism of UDP-GlcNAc 5,6-dehydratase:  a quantum mechanical/molecular mechanical (QM/MM) study. Theor. Chem. Acc., 2014, 133, 1524.

20. Guangcai Ma, Yulin Li, Lixin Wei, Yongjun Liu*, and Chengbu Liu. A density functional theory study on the catalytic mechanism of hydroxycinnamoyl-CoA hydratase-lyase. Int. J. Quantum Chem., 2014, 114, 249–254.

21. Shujun Zhang, Hao Su, Guangcai Ma, Yongjun Liu*. Quantum mechanics and molecular mechanics study of the reaction mechanism of quorum quenching enzyme: N-acyl homoserine lactonase with C6-HSL. RSC Adv., 2016, 6, 23396–23402.

22. Beibei Lin, Hao Su, Guangcai Ma, Yongjun Liu*, Qianqian Hou. Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis. RSC Adv., 2016, 6, 60376–60384.

23. Shujun Zhang, Guangcai Ma, Yongjun Liu*, and Baoping Ling. Theoretical study of the hydrolysis mechanism of 2-pyrone-4, 6-dicarboxylate (PDC) catalyzed by LigI. J. Mol. Graph. Model., 2015, 61, 21−29.

24. 章瑜, 杨新亚, 于海瀛, 马广才*. 烯酰基-辅酶A水合酶催化机理的理论研究. 化学学报, 2017, 75, 494–500.

25. 姚亭吉, 温家乐, 张宁, 于海瀛, 马广才*. 水体氯化消毒中对甲基苯胺转化形成三氯硝基甲烷的分子机制. 科学通报, 2020, 65: 3965–3971.

26. 倪君秀, 徐婷, 温家乐, 徐小琴, 于海瀛, 尉小旋, 马广才*. 细胞色素 P450 酶催化烟草特异性亚硝胺 N’-亚硝基新烟草碱和N’-亚硝基假木贼碱代谢活化的分子机制研究. 生态毒理学报, 2019, 14(4): 73–82.

◆ 学术报告

1. 2019.08，第十届全国环境化学大会，天津，分会口头报告

2. 2017.10，第九届全国环境化学大会，浙江杭州，分会口头报告

3. 2014.06，第十二届全国量子化学会议，山西太原，墙报

◆ 教学情况

为本科生（中文班和英文班）主讲《环境统计与软件应用》、《物理化学》和《基础化学实验II》等课程。

◆ 学生指导

    2018.05指导姚婷吉等同学获2018年国家级大学生创新创业训练计划项目立项。