个人简介

马广才，博士，浙江师范大学地理与环境科学学院副教授，硕士生导师。目前主要从事新污染物代谢转化及毒性作用机制研究，先后在J. Am. Chem. Soc.、Environ. Sci. Technol.、ACS Catal.等国际期刊发表SCI论文50余篇，主持和参与国家自然科学基金及其他省部级项目多项。担任中国毒理学会计算毒理学专业委员会委员、金华市环境保护科学产业联合会环保技术专家、Eco-Environment Health (EEH)期刊青年编委等学术兼职；获浙江省自然科学奖三等奖1项、金华市自然科学优秀论文奖1项。

研究工作简介

1. 新污染物的代谢转化与毒性作用机制研究：基于体外/体内代谢实验和分子模拟相结合的方法研究新污染物(如新型溴代阻燃剂、手性农药等)在生物酶中的代谢动力学过程、转化路径和分子机制，鉴定代谢产物，揭示污染物代谢归趋及代谢物潜在毒性效应，阐明污染物分子结构与毒性效应之间的内在联系；

2. AI驱动的有机污染物代谢路径及产物预测：应用机器学习/深度学习技术、计算毒理学方法揭示多类I相和II相代谢酶联合介导的有机污染物代谢转化过程，识别两相代谢的潜在关联，实现从母体化合物到终产物的多分支、连续性代谢路径的端到端预测，并开发可视化代谢预测工具。

工作学习经历

1. 2024.09−2025.08，大连理工大学，环境学院，访问学者

2. 2016.07−至  今，浙江师范大学，地理与环境科学学院，讲师、副教授

3. 2011.09−2016.06，山东大学，化学与化工学院，博士

4. 2007.09−2011.06，安徽师范大学，化学与材料科学学院，学士

主持/参与科研项目

1. 国家自然科学基金面上项目，“新型溴代阻燃剂的人体代谢转化机制及内分泌激素干扰效应(22176177)”，主持

2. 国家自然科学基金青年项目，“烟草特异亚硝胺致癌物在P450 酶中的代谢活化及毒性作用机制研究(21707122)”，主持

3. 浙江省基础公益研究计划项目，“新型溴代阻燃剂类污染物的P450 酶代谢机制及性激素干扰效应(LY20B070005)”，主持

4. 山东省微生物工程重点实验室开放课题，“理性设计提高漆酶热稳定性的研究”，主持

5. 国家自然科学基金面上项目，“新污染物麝香和酚类抗氧化剂的代谢转化机制及相关毒性效应(22376189)”，参与

6. 浙江省自然科学基金公益项目，“三维Pt-基合金纳米框架结构的设计、可控合成及其在能源催化中的应用(GG18E010009)”，参与

7. 浙江省自然科学基金探索项目，“自清洁型吸附-光催化复合功能材料的设计与应用：去除水中微量抗生素(Y22B073724)”，参与

教学项目

1. 浙江省一流本科国际化线下课程，《环境统计与软件应用(Environmental Statistics and Software Application)》，2022，主持

2. 浙江师范大学一流本科课程重点项目，《环境统计与软件应用》，2022，主持

3. 浙江师范大学青年教师教学改革项目，“问题式学习教学模式与上机模拟在《环境统计与软件应用》课程中的应用”，2017.01−2018.01，主持

学术论文 

—2026年—

1. Zhenkun Sun, Yifan Jin, Jiangmin Liu, Jiawei Huang, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Experimental and computational studies of transformation of sulfachloropyridazine during water chloramination: Kinetics, mechanism and toxicity. Journal of Hazardous Materials, 2026, 507: 141748.

2. Guangcai Ma, Yifan Jin, Yujie Yu, Jiangmin Liu, Hui Shen, Xiaoxuan Wei, Haiying Yu*. Elucidating formation mechanisms of disinfection by-product dichloroacetonitrile and dichloroacetamide from chloramination of amino acids and analogues: An integrated computational-experimental insight. Journal of Hazardous Materials, 2026, 501: 140649.

3. Sisi Cheng, Pengcheng Zou, Xueyu Wang*, Lei Bao, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*. Theoretical insights into nanoparticle interfaces as dual carrier-reactors: Catalytic amplification of methylsiloxane oxidation and secondary organic aerosol formation. Journal of Hazardous Materials, 2026, 501: 140798.

—2025年—

1. Lingmin Jin, Yuchen Lu, Jiawei Huang, Jiangmin Liu, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Metabolism exploration of disinfection byproducts halonitromethanes (HNMs) by cytochrome P450 enzymes and toxicity evaluation. Environmental Research, 2025, 285: 122575.

2. Xiaoxuan Wei, Hanxiao Zhu, Jiagen Li, Sailong Shen, Fang Xiao, Guangcai Ma, Xueyu Wang, Haiying Yu*, Optimizing photodegradation conditions for efficient removal of gatifloxacin: Balancing degradation efficiency and environmental risk. Journal of Cleaner Production, 2025, 505: 145514.

—2024年—

1. Yewen Chen, Jing Zhang, Jiayu Lu, Huifang Shi, Pengfei Lan, Wei Wang, Guangcai Ma*, Xiaoxuan Wei, Xueyu Wang, Haiying Yu*. Computational simulations uncover enantioselective metabolism of chiral triazole fungicides by human CYP450 enzymes: A case study of tebuconazole. Ecotoxicology and Environmental Safety, 2024, 284: 116865.

2. Sisi Cheng, Xueyu Wang*, Pengcheng Zou, Zhenkun Sun, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Theoretical studies on the aqueous phase and graphene heterogeneous degradation of acrylamide and acrylonitrile by HO, ClO, and BrO radicals. Journal of Environmental Management, 2024, 364: 121473.

3. Lingmin Jin, Bangyu Chen, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*. Molecular Interactions Governing the Rat Aryl Hydrocarbon Receptor Activities of Polycyclic Aromatic Compounds and Predictive Model Development. Molecules, 2024, 29: 4619.

4. Zhenyi Chen, Bangyu Chen, Hui Shen, Xunlin Li, Chen Zhou, Guangcai Ma*, Xiaoxuan Wei, Xueyu Wang, Haiying Yu*. Chlorination of aromatic amino acids: Elucidating disinfection byproducts, reaction kinetics, and influence factors. Molecules, 2024, 29: 1879.

5. Xueyu Wang, Sisi Cheng, Pengcheng Zou, Lei Bao, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*. Gas-phase and air-solid interface behavior of phthalate plasticizer and ozone: The influence of indoor mineral dust. Journal of Hazardous Materials, 2024, 477: 135344.

6. Guangcai Ma, Kan Ma, Jing Zhang, Xianglong Zhao, Qiuyi Wang, Yewen Chen, Jiayu Lu, Xiaoxuan Wei, Xueyu Wang, Haiying Yu*. Mechanistic insight into biotransformation of novel triazine-based flame retardant 1,3,5-Tris(2,3-Dibromopropyl)-1,3,5-triazinane-2,4,6-trione by human cytochrome P450s. Environmental Pollution, 2024, 348: 123883.

7. Xueyu Wang, Sisi Cheng, Guangcai Ma, Xiaoxuan Wei, Jichao Fang, HaiyingYu*. Effects of acrylamide on indoor air based on the reactions with O3 and •OH: Mechanism, kinetics, and toxicity evaluation. Journal of Environmental Chemical Engineering, 2024, 12: 112264.

8. Zhenkun Sun, Zhenyi Chen, Marie Celine Chung Lan Mow, Xiaowen Liao, Xiaoxuan Wei*, Guangcai Ma, Xueyu Wang, Haiying Yu*. Chloramine disinfection of levoffoxacin and sulfaphenazole: unraveling novel disinfection byproducts and elucidating formation mechanisms for an enhanced understanding of water treatment. Molecules, 2024, 29: 396.

9. Pengcheng Zou, Sisi Cheng, Xueyu Wang*, MingJun Chen, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. The adsorption of p-hydroxybenzoic acid on graphene oxide under different pH and in-situ desorption in direct current electric field. Journal of Molecular Liquids, 2024, 415:126369.

10. Hao Guo, Haiying Yu, Bohe Teng, Peipei Li, Guangcai Ma, Xueyu Wang, Xiaoxuan Wei*. Application of Carbon Nitride Modified Materials in Photocatalytic Degradation of Antibiotics. Asian Journals of Ecotoxicology, 2024, 19(3): 70-81

—2023年—

1. Guangcai Ma, Qiuyi Wang, Kan Ma, Yewen Chen, Jiayu Lu, Jing Zhang, Xueyu Wang, Xiaoxuan Wei, Haiying Yu*. Enantioselective metabolism of novel chiral insecticide Paichongding by human cytochrome P450 3A4: A computational insight. Environmental Pollution, 2023, 333: 122088.

2. Xueyu Wang, Lei Bao, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*. Homogeneous and air-water interface properties of nicotine relative to aqueous aerosol: adsorption, oxidation, and the influence for the HNCO formation. Science of the Total Environment, 2023, 891: 164503.

3. Huachang Hong, Yuchen Lu, Xiaoyan Zhu, Qiang Wu, Lingmin Jin, Zhigang Jin, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Cytotoxicity of nitrogenous disinfection byproducts: A combined experimental and computational study. Science of the Total Environment, 2023, 856: 159273.

4. Qi Xu, Jian Li, Shang Cao, Guangcai Ma*, Xianglong Zhao, Qiuyi Wang, Xiaoxuan Wei, Haiying Yu*, Zhiguo Wang. Thyroid hormone activities of neutral and anionic hydroxylated polybrominated diphenyl ethers to thyroid receptor β: A molecular dynamics study. Chemosphere, 2023, 311, 136920.

—2022年及以前—

1. Cenyang Han, Wenyou Zhu, Guangcai Ma*, Yewen Chen, Xinqi Li, Xiaoxuan Wei, Haiying Yu*. Computational insight into biotransformation of halophenols by cytochrome P450: Mechanism and reactivity for epoxidation. Chemosphere, 2022, 286, 131708.

2. Yue Jia, Tingji Yao, Guangcai Ma*, Qi Xu, Xianglong Zhao, Hui Ding, Xiaoxuan Wei, Haiying Yu*, Zhiguo Wang. Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450. Molecules, 2022, 27, 2799.

3. Qiang Wu, Siqi Cao, Zhenyi Chen, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Predictive Models of Gas/Particulate Partition Coefficients (K_P) for Polycyclic Aromatic Hydrocarbons and Their Oxygen/Nitrogen Derivatives. Molecules, 2022, 27, 7608.

4. Siqi Cao, Jue Hu, Qiang Wu, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Prediction study on the distribution of polycyclic aromatic hydrocarbons and their halogenated derivatives in the atmospheric particulate phase. Ecotoxicology and Environmental Safety, 2022, 245: 114111.

5. Guangcai Ma, Liming Geng, Yuchen Lu, Xiaoxuan Wei, Haiying Yu*. Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1. Chemosphere, 2021, 263, 128353.

6. Miao Li, Jian Li, Yuchen Lu, Cenyang Han, Xiaoxuan Wei, Guangcai Ma, Haiying Yu*. Developing the QSPR model for predicting the storage lipid/water distribution coefficient of organic compounds. Frontiers of Environmental Science & Engineering, 2021, 15, 24.

7. Guangcai Ma, Haiying Yu,* Cenyang Han, Yue Jia, Xiaoxuan Wei, and Zhiguo Wang*. Binding and Metabolism of Brominated Flame Retardant β‑1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Human Microsomal P450 Enzymes: Insights from Computational Studies. Chemical Research in Toxicology‌, 2020, 33, 1487−1496.

8. Guangcai Ma, Haiying Yu,* Xiaoqin Xu, Liming Geng, Xiaoxuan Wei, Jiale Wen, and Zhiguo Wang*. Molecular Basis for Metabolic Regioselectivity and Mechanism of Cytochrome P450s toward Carcinogenic 4‑(Methylnitrosamino)-(3-pyridyl)-1-butanone. Chemical Research in Toxicology‌, 2020, 33, 436−447.

9. Miao Li, Haiying Yu, Yifei Wang, Jiagen Li, Guangcai Ma, Xiaoxuan Wei*. QSPR models for predicting the adsorption capacity for microplastics of polyethylene, polypropylene and polystyrene. Scientific Reports, 2020, 10: 14597.

10. Lingmin Jin, Haiying Yu*, Liming Geng, Guangcai Ma, Xiaoxuan Wei. In silico study for inhibiting thyroid hormone sulfotransferase activity by halogenated phenolic chemicals. Ecotoxicology and Environmental Safety, 2019, 180: 146-151.

11. Xiaoxuan Wei, Miao Li, Yifei Wang, Lingmin Jin, Guangcai Ma, Haiying Yu*. Developing predictive models for carrying ability of micro-plastics towards organic pollutants. Molecules, 2019, 24: 1784.

12. Guangcai Ma, Haiying Yu*, Ting Xu, Xiaoxuan Wei, Jianrong Chen, Hongjun Lin, Gerrit Schüürmann. Computational Insight into the Activation Mechanism of Carcinogenic N’-Nitrosonornicotine (NNN) Catalyzed by Cytochrome P450. Environmental Science & Technology, 2018, 52, 11838−11847.

13. Serge Bakire, Xinya Yang, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*, Jianrong Chen, Hongjun Lin. Developing predictive models for toxicity of organic chemicals to green algae based on mode of action. Chemosphere, 2018, 190: 463-470.

14. Hao Su, Guangcai Ma, Yongjun Liu. Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes. Inorganic Chemistry, 2018, 57, 11738−11745.

15. Guangcai Ma, Quan Yuan, Haiying Yu*, Hongjun Lin, Jianrong Chen, Huachang Hong. Development and evaluation of predictive model for bovine serum albumin-water partition coefficients of neutral organic chemicals. Ecotoxicology and Environmental Safety‌, 2017, 138, 92–97.

16. Guangcai Ma, Wenyou Zhu, Yongjun Liu*. QM/MM studies on the calcium-assisted β-elimination mechanism of pectate lyase from bacillus subtilis. Proteins-structure Function & Bioinformatics, 2016, 84, 1606–1615.

17. Beibei Lin, Guangcai Ma, Liu, Yongjun Liu*. Mechanism of the Glutathione Persulfide Oxidation Process Catalyzed by Ethylmalonic Encephalopathy Protein 1. ACS Catalysis, 2016, 6, 7010–7020.

18. Guangcai Ma, Wenyou Zhu, Hao Su, Na Cheng, Yongjun Liu*. Uncoupled epimerization and desaturation by carbapenem synthase: mechanistic insights from QM/MM studies. ACS Catal., 2015, 5, 5556–5566.

19. Guangcai Ma, Na Cheng, Hao Su, Yongjun Liu*. Exploring the substrate-assisted acetylation mechanism by UDP-linked sugar N-acetyltransferase from QM/MM calculations: the role of residue Asn84 and the effects of starting geometries. RSC Advances, 2015, 5, 7781–7788.

20. Guangcai Ma, Lihua Dong, Yongjun Liu*. Insights into the catalytic mechanism of dTDP-glucose 4,6-dehydratase from quantum mechanics/molecular mechanics simulations. RSC Advances, 2014, 4, 35449–35458.

21.  Xiaohua Chen*, Guangcai Ma, Weichao Sun, Hongjing Dai, Dong Xiao, Yanfang Zhang, Yongjun Liu*, and Yuxiang Bu. Water promoting electron hole transport between tyrosine and cysteine in proteins via a special mechanism: double proton coupled electron transfer. Journal Of The American Chemical Society, 2014, 136, 4515−4524.

22. Guangcai Ma, and Yongjun Liu*. The reaction mechanism of UDP-GlcNAc 5,6-dehydratase:  a quantum mechanical/molecular mechanical (QM/MM) study. ‌Theoretical Chemistry Accounts‌, 2014, 133, 1524.

23. Guangcai Ma, Yulin Li, Lixin Wei, Yongjun Liu*, and Chengbu Liu. A density functional theory study on the catalytic mechanism of hydroxycinnamoyl-CoA hydratase-lyase. International Journal of Quantum Chemistry, 2014, 114, 249–254.

24. Shujun Zhang, Hao Su, Guangcai Ma, Yongjun Liu*. Quantum mechanics and molecular mechanics study of the reaction mechanism of quorum quenching enzyme: N-acyl homoserine lactonase with C6-HSL. RSC Advances, 2016, 6, 23396–23402.

25. Beibei Lin, Hao Su, Guangcai Ma, Yongjun Liu*, Qianqian Hou. Theoretical study of the hydrolysis mechanism of dihydrocoumarin catalyzed by serum paraoxonase 1 (PON1): different roles of Glu53 and His115 for catalysis. RSC Advances, 2016, 6, 60376–60384.

26. Shujun Zhang, Guangcai Ma, Yongjun Liu*, and Baoping Ling. Theoretical study of the hydrolysis mechanism of 2-pyrone-4, 6-dicarboxylate (PDC) catalyzed by LigI. Journal of Molecular Graphics and Modelling, 2015, 61, 21−29.

27. 章瑜, 杨新亚, 于海瀛, 马广才*. 烯酰基-辅酶A水合酶催化机理的理论研究. 化学学报, 2017, 75, 494–500.

28. 姚亭吉, 温家乐, 张宁, 于海瀛, 马广才*. 水体氯化消毒中对甲基苯胺转化形成三氯硝基甲烷的分子机制. 科学通报, 2020, 65: 3965–3971.

29. 倪君秀, 徐婷, 温家乐, 徐小琴, 于海瀛, 尉小旋, 马广才*. 细胞色素 P450 酶催化烟草特异性亚硝胺 N’-亚硝基新烟草碱和N’-亚硝基假木贼碱代谢活化的分子机制研究. 生态毒理学报, 2019, 14(4): 73–82.

学术报告

1. 2025.05，第十九届持久性有机污染物论坛暨化学品环境安全大会，重庆，分会口头报告

2. 2025.05，AI 赋能化学物质健康风险防控技术研讨会，石河子，分会口头报告

3. 2024.07，计算毒理学青年学术报告会，线上，邀请报告

4. 2024.05，第六届新污染物环境健 康风险及防控学术会议，天津，分会口头报告

5. 2023.10，外源化学物质健康与环境风险防控技术研讨会，九江，分会口头报告

6. 2019.08，第十届全国环境化学大会，天津，分会口头报告

7. 2017.10，第九届全国环境化学大会，浙江杭州，分会口头报告

8. 2014.06，第十二届全国量子化学会议，山西太原，墙报

获奖情况

1. 浙江省自然科学三等奖(3/5)，2026年

2. 金华市自然科学优秀论文奖三等(1/4)，2025年

3. 浙江师范大学优秀班主任，2019、2021、2022年

4. 山东大学博士研究生国家奖学金，2015年

5. 山东大学研究生优秀学术成果奖，2015年

6. 山东大学“晨曦杯”专业优胜奖，2014年

教学情况

现主讲本科生课程《环境统计与软件应用(中、英文)》，曾主讲《物理化学》、《基础化学实验II》和《大学化学》。

学生指导

指导学生名单：

在读研究生：2025级：沈新、吴诗羽；2024级：姜醒醒、郭翔龙；2023级：蓝鹏飞、史荟芳、王伟

已毕业研究生：2022级：陈叶雯、张静、马侃；2021级：马侃、王秋怡；2020级：徐琦、赵祥龙；2019级：丁晖、贾越；2017级：温家乐、徐小琴

指导学生获奖和课题：

1. 姜醒醒, 史荟芳, 沈新. 第四届浙江师范大学研究生环境科学与工程创新实践能力大赛二等奖, 2025年

2. 陈叶雯, 张静, 史荟芳. 第三届浙江师范大学研究生环境科学与工程创新实践能力大赛一等奖, 2024年

3. 史荟芳, 张静, 陈叶雯. 第三届浙江师范大学研究生环境科学与工程创新实践能力大赛三等奖, 2024年

4. 李鑫祺, 伍飞, 罗钦方. 第三届浙江省大学生环境生态科技创新大赛三等奖, 2020年

5. 韩岑洋. 省级大学生创新创业训练计划项目, 2020年

6. 姚婷吉. 国家级大学生创新创业训练计划项目, 2019年

7. 姚婷吉. 国家级大学生创新创业训练计划项目, 2018年