刘飏子
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刘飏子，浙江师范大学“双龙学者”特聘教授，副教授，硕士生导师。2012年本科毕业于华东理工大学 (药学院)，后于2019年12月获华东理工大学博士学位，师从邓卫平教授。2020年1月至2021年12月，在中国科学院上海有机化学研究所从事博士后研究工作，合作导师为游书力研究员。2022年1月，以“双龙学者”特聘教授身份加入浙江师范大学化学与材料科学学院“手性药物绿色合成”团队。目前，主持国家自然科学青年基金一项。已在《Nat. Synth.》《Angew. Chem. Int. Ed.》《ACS Catal.》《Chem. Sci.》等国际权威期刊以第一作者或通讯作者身份发表论文15篇。
主要研究方向包括：
1、基于新概念、新试剂和新反应的手性中环化合物的催化不对称合成；
2、杂原子及非经典手性的催化不对称构建；
3、(手性)药物的绿色合成工艺开发。
代表性论文：
2025
15. Wenqi Liu, Zhijie Ling, Yang-Zi Liu*, Wei-Ping Deng*. Catalytic Asymmetric Construction of Remote P or Other Heteroatom (Si/S) Stereogenic Axially Chiral Scaffolds. Chem. Sci. 2025, DOI: 10.1039/D5SC08143B. (2025 Chemical Science HOT Article)
14. Na Lin, Jun-Tao Chen, Yang-Zi Liu*, Wei-Ping Deng*. Vinylarylcyclopropanes (VACPs): All-carbon dipole precursors for controlling linear regioselectivity in cycloaddition reactions. ACS Catal. 2025, 15, 11587-11593. (封面文章)
13. Linli Xu, Zhijie Ling, Xinhao Lu, Yang-Zi Liu*, Wei-Ping Deng*. Single-step assembly of azabicyclo[3.3.0]octance systems via palladium-photoredox domino cycloaddition/transannular cascades. Sci. China Chem. 2025, doi.org/10.1007/s11426-025-2747-x.
12. Shuixiu Su, Ying Chen, Qiyu Wang, Jian Zhang, Yang-Zi Liu*, Wei-Ping Deng*. Enantioselective Construction of Spirooxindole-γ-butyrolactones via NHC-Bound Isobenzofulvene [10π+2π] Cycloaddition. Chin. J. Chem. 2025, 43, 1983-1987. (封面文章)
11. Xiaochun Liu, Xiang-Feng Ding, Yang-Zi Liu*, Wei-Ping Deng*. Enantioselective Construction of Tetrahydro-α-Carbolines via Organocatalytic Friedel-Crafts Alkylation/N-Hemiacetalization of 2-Aminoindoles with Enals. Eur. J. Org. Chem. 2025, 28, e202401431.
2022-2024
10. Yang-Zi Liu, Chao Zheng, Shu-Li You*. Synthesis of Medium-Sized Rings by Z-Retentive Asymmetric Allylic Substitution-Enabled Intermolecular Cascade Cyclization under Iridium/Cinchona Catalysis. ACS Catal. 2024, 14, 15743-15750.
9. Xinhao Lu, Yi Wang, Chenghan He, Yang-Zi Liu*, Wei-Ping Deng*. Synthesis of Indole-Fused Eight-Membered Oxa-Ringsvia Palladium-Catalyzed Asymmetric [4+4] Cycloadditionof Indole-2,3-Quinodimethanes with 2-AlkylidenetrimethyleneCarbonates. Chin. J. Chem. 2024, 42, 3393-3398.
8. Jun-Tao Chen, Na Lin, Linli Xu, Yi Wang, Xiaoyan Luo, Yang-Zi Liu*, Wei-Ping Deng*. Palladium-catalyzed [6 + 4] cycloaddition with π-allyl all-carbon 1,6-dipole for the synthesis of ten-membered heterocycles. Org. Chem. Front. 2024, 11, 1299-1304.
7. Wenqi Liu‡, Meng Zang‡, Jian Zhang, Quannan Wang, Yang-Zi Liu*, Wei-Ping Deng*. Pd-Catalyzed exclusively regioselective [5+4] cycloaddition for the construction of 1,5-di/ox-azonanes. Org. Chem. Front. 2023, 10, 1680-1685.
6. Jian Zhang, Ying Chen, Quannan Wang, Jiahuan Shen, Yang-Zi Liu*, Wei-Ping Deng*. Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors. Chin. J. Org. Chem. 2022, 42, 3051-3101. (Review)(封面文章)
before ZJNU
5. Yang-Zi Liu, Hao Song, Chao Zheng, Shu-Li You*. Cascade asymmetric dearomative cyclization reactions via transition-metal-catalysis. Nature Synthesis 2022, 1, 203-216. (Invited review)
4. Yang-Zi Liu*‡, Zhongao Wang‡, Zesheng Huang, Wu-Lin Yang, Wei-Ping Deng*. Sulfone as a Transient Activating Group in the Palladium-Catalyzed Asymmetric [4+3] Cycloaddition of Trimethylenemethane Enabling the Enantioselective Synthesis of Fused Azepines. Org. Lett. 2021, 23, 948-952.
3. Yang-Zi Liu, Zhongao Wang, Zesheng Huang, Xing Zheng, Wu-Lin Yang*, Wei-Ping Deng*. Palladium-Catalyzed Asymmetric [4+3] Cyclization of Trimethylenemethane: Regio-, Diastereo-, and Enantioselective Construction of Benzofuro[3,2-b]azepine Skeletons. Angew. Chem. Int. Ed. 2020, 59, 1238-1242.
2. Yang-Zi Liu, Shao-Jing Shang, Jing-Yan Zhu, Wu-Lin Yang*, Wei-Ping Deng*. Regioselective and Stereoselective [3+3] Annulation of Ketones Derived Azomethine Ylides with 2-Indolylethylenes: Direct Access to Highly Substituted Tetrahydro-γ-Carbolines. Adv. Synth. Catal. 2018, 360, 2191-2203.
1. Yang-Zi Liu‡, Shao-Jing Shang‡, Wu-Lin Yang, Xiaoyan Luo*, Wei-Ping Deng*. Stereoselective Synthesis of Pyrrolidines Containing a 3-Fluoro Quaternary Stereocenter via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition. J. Org. Chem. 2017, 82, 11141-11149.
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