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Copper-catalyzed coupling of 2-vinyl benzaldehydes with 3-alkenyl 2-bromocarbonyls for the rapid construction of 3,4-cyclopenta-1-tetralones

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First Author : Hui Zhu

Date of Publication : 2016-01-01

Journal : Tetrahedron Letters

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.57

Issue : No.21

Page Number : 2331-2335

ISSN : 0040-4039

Key Words : Ketone;Aldehyde;Copper;Radical;Cascade;annulation

Abstract : A straightforward, efficient, and highly diastereoselective method for the synthesis of 3,4-cyclopenta-1-tetralones has been realized via the copper-catalyzed coupling of 2-vinyl benzaldehydes with 3-alkenyl 2-bromocarbonyls. Subsequent reduction with l-s

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