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Preparation of (Z)-α,β-Disubstituted Enamides via Palladium-Catalyzed Addition of Boronic Acids to Ynamides

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First Author : Yuanfa Yang

Date of Publication : 2014-01-01

Journal : The Journal of Organic Chemistry

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.79

Issue : No.19

Page Number : 9319-9324

ISSN : 0022-3263

Abstract : A Pd-catalyzed, highly regio- and stereoselective addition of boronic acids to ynamides has been realized. This protocol generates (Z)-α,β-disubstituted enamides in high yields with excellent regio- and stereoselectivity under the mild reaction conditions

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Pre One : Synthesis of (Z)-1-Thio- and (Z)-2-Thio-1-alkenyl Boronates via Copper-Catalyzed Regiodivergent Hydroboration of Thioacetylenes: An Experimental and Theoretical Study

Next One : Copper-catalyzed trans-carbohalogenation of terminal alkynes with functionalized tertiary alkyl halides.

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