基本情况：
博士(后)，副教授 (h-index=20)，硕士/博士生导师，基于生物组学大数据的挖掘（干实验）与分子生物学实验（湿实验）的交叉技术手段，解析药食同源植物功效成分生物合成的分子机理及其开发利用。以第一作者或通讯作者在New Phytologist, Plant Biotechnology Journal, Plant Physiology, Horticulture Research, Communications Biology, Industrial Crops and Products, Plant Physiology and Biochemistry, Medicinal Plant Biology等期刊发表论文30余篇，其中2篇入选ESI高被引论文，参与Nature, Plant Cell, Molecular plant等研究工作 ；以第一发明人授权国家发明专利2项，以主要完成人获省级科技进步一等奖1项、自然 科学一等奖1项、国家科技进步二等奖提名1项；参编学术专著2部，参与编制省级标准和《政府咨询报告》若干项，其中咨询报告被全国政协采纳；主持或参与省部级及以上项目十余项。在国际共生固氮会议、中国药用植物学大会、长三角植物学研讨会、浙江省遗传学以及浙江省植物学会等会议上作学术报告若干次。学术兼职：新疆兵团高校高层次人才讲座学者，全国药用植物与植物药专业委员会青年委员、浙江省植物学会青年工作委员会委员、浙江省林下经济委员会委员、Horticulture Research及Medicinal Plant Biology期刊青年编委，Genes等SCI期刊客座编辑，Molecular Ecology Resources、Industrial Crops and Products、Plant Physiology and Biochemistry、GigaScience等SCI期刊审稿人，国家自然科学基金通讯评审专家。
研究兴趣：
以红花、藏红花、黄精等药食同源植物为主要研究对象，通过干实验（生物信息学分析）和湿实验（分子生化实验）技术手段的结合，开展优异种质资源的挖掘及开发利用的研究，具体如下：
1、利用基因组学、代谢组学、蛋白质组学等多组学联合分析的方法，开展药用植物活性成分的鉴定、分子调控及道地性研究；
2、基于遗传学、系统生物学、分子生物学等技术，解析药用植物活性成分形成的遗传及演化机制，开发功能标记辅助优异品种选育与利用；
3、基于机器学习、深度学习等人工智能技术、分子生化技术，解析天然产物合成途径关键酶的催化机制，并对酶进行定点改造，以期实现天然产物异源高效生物合成。
主要承担项目：
(1) 2025-2028，国家自然科学基金，面上项目(32470395), 主持，在研。
(2) 2025-2026, 金华市公益基金，一般项目(2024-4-015)，主持，在研。
(3) 2024-2026，浙江省自然科学基金，探索一般(LY24C020002)，主持，在研。
(4) 2024-2027，国家自然科学基金，面上项目(32371838)，联合主持，在研。
(5) 2022-2025，国家自然科学基金，地区基金(32160355)，联合主持，在研。
(6) 2020-2022，国家重点实验室开放课题，重点课题(BRZD2003)，主持，结题。
(7) 2019-2020, 湖北省自然科学基金，青年项目(BZQ19001)，主持，结题。
(8) 2015-2017, 中国博士后科学基金面上项目，(2015M582235), 主持，结题。
部分一作或通讯论文（#共一作者；*通讯作者）：
(1) Yan Hu, Xiaona Lu, Jingqi Wang, Zelin Niu, Ruru Hao, Ruting Li, Jiangzhe Zhao, Kewei Zhang, Rongna Wang, Zhuojing Ying, Meihao Sun, Zhihua Wu*. Comprehensive analysis of AP2/ERFs reveals their functional divergence in safflower flavonoid biosynthesis and stress response. Plant Physiology and Biochemistry, 2026, 111034.
(2) Ruru Hao, Yang Yuan, Yan Hu, Rui Li, Xiaona Lu, Meihao Sun, Rogerio Chiulele, Zhihua Wu*. Comprehensive characterization of safflower cytochrome P450 family and the role of CtCYP41 in flavonoid biosynthesis and drought response. BMC Plant Biology. In press.
(3) Tongrui Song, Hongyan Jin, Jing Li, Qi Ning, Donghui Miao, Yidan Yang, Zhibin Cui, Zhijun Li, Zhihua Wu*, Peipei Jiao*. Characterisation of the ARF Gene Family in Salicaceae and Functional Analysis of PeARF18 in Heteromorphic Leaf Development of Populus euphratica. International Journal of Molecular Sciences, 2026, 27(1), 335.
(4) Jing Li, Hongyan Jin, Tongrui Song, Donghui Miao, Qi Ning, Jianhao Sun, Zhijun L, Peipei Jiao*, Zhihua Wu*.Identification of the Populus euphratica XTHs Gene Family and the Response of PeXTH7 to Abiotic Stress. Plants, 2025, 14(24), 3847.
(5) Shoucheng Pu, Jufang Gong, Meihao Sun, Zunhong Hu, Zhihua Wu*. The Molecular Mechanism of Polysaccharides from Polygonatum cyrtonema Hua in Improving Hyperuricemia by Regulating Key Targets of Uric Acid Metabolism in Mice. Foods, 2025, 14(19), 3396.
(6) Zhihua Wu#*, Yan Hu#, Ruru Hao, Ruting Li, Xiaona Lu, Mdachi Winfrida Itale, Yang Yuan, Xiaoxian Zhu, Jiaqiang Zhang, Longxiang Wang, Meihao Sun, Xianfei Hou. Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower. International Journal of Molecular Sciences, 2025, 26(8), 3867.
(7) Qiu Chen, Liu Shuo, Sun Jianhao, Gai Zhongshuai, Han Xiaoli, Jiao Peipei, Zhai Juntuan, Yang Yuqi, Jiang Zhenbo, Liu Hong, Qin Rui, Tie Jun, Wu Zhihua*, Li Zhijun*. DNA methylation profile revealed the dynamically epigenetic regulation of the distinct heteromorphic leaf development in Populus euphratica. Industrial Crops and Products, 2024, 126: 118688.
(8) Jianhao Sun; Jindong Xu; Chen Qiu; Juntuan Zhai; Shanhe Zhang; Xiao Zhang; Zhihua Wu*; Zhijun Li*; The chromosome-scale genome and population genomics reveal the adaptative evolution of Populus pruinosa to desertification environment, Horticulture Research, 2024, uhae034: 1-34.
(9) Shuo Liu#, Zhihua Wu#, Tiange Yang, Jindong Xu, Saimire Aishan, Erdai Qin, Kang Ma, Jiao Liu, Rui Qin, Jiangqing Wang, Jun Tie & Hong Liu. The Chrysosplenium sinicum genome provides insights into adaptive evolution of shade plants. Communications Biology, 2024, 7(1), 1004.
(10) Zhihua Wu#*; Ruting Li#; Meihao Sun; Xueli Hu; Meihua Xiao; Zunhong Hu; Peipei Jiao; Shoucheng Pu; Juntuan Zhai; Jiaqiang Zhang; Current advances of Carthamus tinctorius L.: a review of its application and molecular regulation of flavonoid biosynthesis, Medicinal Plant Biology, 2024, 3(e004): 1-11.
(11) Yuqi Yang, Jianhao Sun, Chen Qiu, Peipei Jiao, Houling Wang, Zhihua Wu* and Zhijun Li*. Comparative genomic analysis of the Growth-Regulating Factors-Interacting Factors (GIFs) in six Salicaceae species and functional analysis of PeGIF3 reveals their regulatory role in Populus heteromorphic leaves. BMC Genomics, 2024, (2024) 25:317.
(12) Zhihua Wu#*, Zhenbo Jiang#, Zhijun Li*, Peipei Jiao, Juntuan Zhai, Shuo Liu, Xiaoli Han, Shanhe Zhang, Jianhao Sun, Zhongshuai Gai, Chen Qiu, Jindong Xu, Hong Liu, Rui Qin, Rui Lu. Multi-omics analysis reveals spatiotemporal regulation and function of heteromorphic leaves in Populus. Plant Physiology, 2023, 192(1): 188-204.
(13) Tiange Yang#, Zhihua Wu#, Jun Tie, Rui Qin, Jiangqing Wang, Hong Liu. A Comprehensive Analysis of Chloroplast Genome Provides New Insights into the Evolution of the Genus Chrysosplenium. Int. J. Mol. Sci. 2023, 24, 14735.
(14) Jianhao Sun, Jindong Xu, Wenrui Qu, Xiaoli Han, Chen Qiu, Zhongshuai Gai, Juntuan Zhai, Rui Qin, Hong Liu, Zhihua Wu*, Zhijun Li*. Genome-wide analysis of R2R3-MYB transcription factors reveals their differential responses to drought stress and ABA treatment in desert poplar (Populus euphratica). Gene, 2023, 855(2023):147124.
(15) X.L. HAN, C. QIU, J.H. SUN, J.D. XU, X. ZHANG, J.T. ZHAI, S.H. ZHANG, Z.H. WU*, Z.J. LI*. Identification of AP2/ERF gene family of Salicaceae and their response to salt stress, abscisic acid, and gibberellic acid in Populus euphratica seeds. Biologia Plantarum, 2023, 67: 88-99.
(16) Zhihua Wu*, Tiange Yang, Rui Qin, Hong Liu. Complete mitogenome and phylogenetic analysis of the Carthamus tinctorius L. Genes, 2023, 14, 979.
(17) WANG, J. N, XU, J. D., SUN, J. H., QIU, C., WU, Z. H.*, LI, Z. J*. Genome-wide identification of TCP transcription factors family in Populus sect. turanga (Populus pruinosa Schrenk and Populus euphratica Olive) revealed the roles of TCPs in leaf morphology. Applied Ecology and Environmental Research, 2023, 21(2):1665-1696.
(18) Shanhe Zhang#, Zhihua Wu#, De Ma#, Juntuan Zhai, Xiaoli Han, Zhenbo Jiang, Shuo Liu, Jingdong Xu, Peipei Jiao* & Zhijun Li*. Chromosome-scale assemblies of the male and female Populus euphratica genomes reveal the molecular basis of sex determination and sexual dimorphism. Communications Biology, 2022, 1186 (2022).
(19) Zhihua Wu#, Hong Liu#, Wei Zhan#, Zhichao Yu, Erdai Qin, Shuo Liu, Tiange Yang, Niyan Xiang, Dave Kudrna, Yan Chen, Seunghee Lee, Gang Li, Rod A. Wing, Jiao Liu, Hairong Xiong, Chunjiao Xia, Yongzhong Xing, Jianwei Zhang* & Rui Qin*. The chromosome-scale reference genome of safflower (Carthamus tinctorius) provides insights into linoleic acid and flavonoid biosynthesis. Plant Biotechnology Journal, 2021, 19(9):1725-1742.(封面论文，ESI高被引论文)
(20) Zhongshuai Gai, Juntuan Zhai, Xiangxiang Chen, Peipei Jiao, Shanhe Zhang, Jianhao Sun, Rui Qin, Hong Liu, Zhihua Wu* and Zhijun Li*, Phylogeography reveals geographic and environmental factors driving genetic differentiation of Populus sect. Turanga in northwest China. Frontiers in Plant Science, 2021, 12:705083.
(21) Zhihua Wu#, Rui Liao#, Tiange Yang, Xiang Dong, Deqing Lan, Rui Qin and Hong Liu*. Analysis of six chloroplast genomes provides insight into the evolution of Chrysosplenium (Saxifragaceae). BMC Genomics, 2020, 21(1):621.
(22) Zhihua Wu#, Wen Huang#, Erdai Qin, Shuo Liu, Huan Liu, Aleel K. Grennan, Hong Liu and Rui Qin*. Comprehensive Identification and Expression Profiling of Circular RNAs During Nodule Development in Phaseolus vulgaris. Frontiers in Plant Science, 2020, 11: 587185.
(23) Peipei Jiao#, Zhihua Wu#, Xu Wang, Zhenbo Jiang, Yanqin Wang, Hong Liu, Rui Qin, and Zhijun Li*. Short term transcriptomic responses of Populus euphratica roots and leaves to drought stress. Journal of Forestry Research, 2020, 32: 841–853 (2021).
(24) Zhihua Wu, Hong Liu, Wen Huang, Lisha Yi, Erdai Qin, Tiange Yang, Jing Wang and Rui Qin*. Genome-Wide Identification, Characterization, and Regulation of RWP-RK Gene Family in the Nitrogen-Fixing Clade. Plants-Basel, 2020, 9(9):1178.
(25) Zhihua Wu, Meirong Wang, Siyu Yang, Shengcai Chen, Xu Chen, Chang Liu, Shixiang Wang, Haijiao Wang, Bao Zhang, Hong Liu, Rui Qin, and Xuelu Wang*. A global coexpression network of soybean genes gives insight into the evolution of nodulation in non-legumes and legumes. New Phytologist, 2019, 223 (4): 2104-2119.
(26) Zhihua Wu, Rui Liao, Xiang Dong, Rui Qin, Hong Liu. Complete chloroplast genome sequence of Carthamus tinctorius L. from PacBio Sequel platform. Mitochondrial DNA Part B, 2019, 4:2635–2636.
(27) Songtao Gui#, Zhihua Wu#, Hongyuan Zhang, Yinzhen Zheng, Zhixuan Zhu, Dequan Liang, and Yi Ding*. The mitochondrial genome map of Nelumbo nucifera reveals ancient evolutionary features. Scientific Reports, 2016, 6:30158 | DOI: 10.1038/srep30158.
(28) Zhihua Wu, Songtao Gui, Zhiwu Quan, Lei Pan, Shuzhen Wang, Weidong Ke, Dequan Liang and Yi Ding*. A precise chloroplast genome of Nelumbo nucifera (Nelumbonaceae) evaluated with Sanger, Illumina MiSeq, and PacBio RS II sequencing platforms: insight into the plastid evolution of basal eudicots. BMC Plant Biology, 2014, 14:289.
(29) Zhihua Wu, Songtao Gui, Shuzhen Wang, and Yi Ding*. Molecular evolution and functional characterisation of an ancient phenylalanine ammonia-lyase gene (NnPAL1) from Nelumbo nucifera: novel insight into the evolution of the PAL family in angiosperms. BMC Evolutionary Biology, 2014, 14:100.
(30) Zhihua Wu, Shuzhen Wang, Jihong Hu, Feng Li, Weidong Ke, and Yi Ding*. Development and characterization of microsatellite markers for Sagittaria trifolia var. sinensis (Alismataceae). American Journal of Botany, 2011, 98:e36-e38.
部分参与作者论文：
(1) Bao Zhu#, Yanjun Zhang# , Rong Gao# , Zhihua Wu, Wei Zhang, Chao Zhang, Penghong Zhang, Can Ye, Linbo Yao, Ying Jin, Hui Mao, Peiyao Tou, Peng Huang, Jiangzhe Zhao, Qiao Zhao, Chang-Jun Liu, Kewe Zhang*. Complete biosynthesis of salicylic acid from phenylalanine in plants. Nature, 2025,645(8079):218-227.
(2) Jiayi Zhao, Huiqi Fu, Zhengze Wang, Min Zhang, Yaoqiong Liang, Xueying Cui, Wenjing Pan, Ziming Ren, Zhihua Wu, Yujie Zhang, Xin Gui, Li Huo, Xiaoning Lei, Chong Wang, Arp Schnittger, Wojciech P Pawlowski, Bing Liu*. Genetic variation in Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis. Plant Physiology, 2025, 197(1), kiae671.
(3) Ting Pan, Yangxuan Liu, Xufan Hu, Pengwei Li, Chengcheng Lin, Yuying Tang, Wei Tang, Yongsheng Liu, Liang Guo, Chanhong Kim, Jun Fang, Honghui Lin, Zhihua Wu, Eduardo Blumwald, Songhu Wang*. Stress-induced endocytosis from chloroplast inner envelope membrane is mediated by CHLOROPLAST VESICULATION but inhibited by GAPC. Cell Reports, 2023, 42(10), 113208.
(4) Shengcai Chen , Yaqi Peng, Qi Lv, Jing Liu, Zhihua Wu, Haijiao Wang, Xuelu Wang*. Characterization of two constitutive promoters RPS28 and EIF1 for studying soybean growth, development, and symbiotic nodule development. aBIOTECH, 2022, 3, 2, (99-109).
(5) Yingjie Ning, Qingpei Liu, Chong Wang, Erdai Qin, Zhihua Wu, Minghui Wang, Ke Yang, Ibrahim Eid Elesawi, Chunli Chen, Hong Liu, Rui Qin, Bing Liu*. Heat stress interferes with formation of double-strand breaks and homolog synapsis. Plant Physiology, 2021, 185(4),1783–1797.
(6) Dongxu Wang, Cangjing Yang, Haijiao Wang, Zhihua Wu, Jianjun Jiang, Jingjing Liu, Zhuona He, Fang Chang, Hong Ma, Xuelu Wang*. BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis. Molecular Plant, 2018,10(2):297-308.
(7) Songtao Gui, Jing Peng, Xiaolei Wang, Zhihua Wu, Rui Cao, Jérôme Salse, Hongyuan Zhang, Zhixuan Zhu, Qiuju Xia, Zhiwu Quan, Liping Shu, Wedong Ke, Yi Ding*. Improving Nelumbo nucifera genome assemblies using high-resolution genetic maps and BioNano genome mapping reveals ancient chromosome rearrangements. Plant Journal, 2018, 94(4), 721–734.
(8) Shenglong Qiao#, Shiyong Sun#, Linlin Wang, Zhihua Wu, Chengxiang Li, Xiaoming Li, Tao Wang, Linna Leng, Weisheng Tian, Tiegang Lu, Xuelu Wang*. The RLA1/SMOS1 Transcription Factor Functions with OsBZR1 to Regulate Brassinosteroid Signaling and Rice Architecture. Plant Cell, 2017,29(2):292-309. （高被引论文）
(9) Dongxu Wang, Cangjing Yang, Haijiao Wang, Zhihua Wu, Jianjun Jiang, Jingjing Liu, Zhuona He, Fang Chang, Hong Ma, Xuelu Wang*. BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis. Molecular Plant, 2017, 10(2), 297–308.
(10) Jianjun Jiang, Tao Wang, Zhihua Wu, Jie Wang, Chi Zhang, Haijiao Wang, Zhi-Xin Wang, Xuelu Wang *. The Intrinsically Disordered Protein BKI1 Is Essential for Inhibiting BRI1 Signaling in Plants. Molecular Plant, 2015,8(11):1675-8.
最新论文信息见个人ORCID：https://orcid.org/0000-0002-2895-7256
Scopus ID: https://www.scopus.com/authid/detail.uri?authorId=57209797129#
论文之外的其他主要成果：
（1）2020年，专著《胡杨和灰杨抗旱的生理与分子机制研究》，科学出版社, 3/11。
（2）2021年，专著《胡杨和灰杨的异形叶性及生长适应策略》，科学出版社，3/8。
（3）2021年，国家发明专利，一种基于Illumina技术组装中华金腰叶绿体基因组序列的方法（ZL201910546474.9), 1/5。
（4）2022年，新疆兵团科技进步一等奖，塔里木河流域胡杨林多维保育恢复关键技术与应用，3/15。
（5）2023年，国家发明专利，一种利用CLEC基因鉴定猪肉成分的TaqMan荧光定量PCR方法及其应用（ZL201911335337.7），1/6。
（6）2023年，国家发明专利，基于BSA混池测序分析开发胡杨性别鉴定的特异DNA分子标记（ZL 202011213071.1），2/8；
（7）2023年，胡杨雌雄株分子鉴定技术规程（DB65/T4640-2022），2/10。
（8）2023年，政府咨询报告,《关于加大新疆胡杨遗传资源保护及种质资源圃建设的建议》获新疆自治区党委批示并被全国政协所采纳，4/5。
(9) 2024年，政府咨询报告,《加快中亚胡杨种质资源收集保育与创新挖掘 为胡杨资源利用储备基因库》被全国政协采纳，4/4。
（10）2024年，新疆兵团自然科学一等奖，胡杨适应干旱的结构生理特征及分子机制，4/6。
人才培养及教学：
（1）2020年，第四届全国大学生生命科学竞赛一等奖，第一指导老师。
（2）2021年，第五届全国大学生生命科学竞赛三等奖，第一指导老师。
（3）2022年，第六届全国大学生生命科学竞赛三等奖，第一指导老师。
（4）2023年，本科生国家级创新创业训练计划项目，第一指导老师。
（5）2023年，研究生省新苗计划项目，第一指导老师。
（6）2023年，浙江省第三届高校教师教学创新大赛三等奖，第一完成人。
主讲课程：
本科生《生物化学与分子生物学》、《分子生物学》；研究生《高级生物化学》。
欢迎对生物信息学、基因组学、合成生物学、分子生物学与生物化学、生物与医药等研究感兴趣的本科生、研究生同学加入！
Email: zhuawu@zjnu.edu.cn
Tel: 13720103439/13738934268