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Molecular Recognition of the Hybrid‐2 Human Telomeric G‐Quadruplex by Epiberberine: Insights into Conversion of Telomeric G‐Quadruplex Structures.

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Date of Publication : 2018-01-01

Journal : Angewandte Chemie International Edition

Affiliation of Author(s) : 物理化学研究所

Document Type : 期刊

Volume : Vol.57

Issue : No.34

Page Number : 10888-10893

ISSN : 1433-7851

Key Words : BERBERINE;*TELOMERES;*QUADRUPLEX;nucleic;acids;*GENETIC;polymorphisms;*NUCLEAR;magnetic;resonance

Abstract : Human telomeres can form DNA G‐quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal n

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