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In Silico Investigation of the Thyroid Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers.

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First Author : Yu H

Date of Publication : 2015-01-01

Journal : Chem Res Toxicol.

Affiliation of Author(s) : 林红军

Document Type : 期刊

Volume : Vol.28

Issue : No.8

Page Number : 1538-1545

ISSN : 0893-228x;1520-5010

Abstract : Polybrominated diphenyl ethers (PBDEs) have been shown to have a disruptive effect on the thyroid hormone system, and one possible mechanism is the direct binding of their hydroxylated metabolites (HO-PBDEs) to thyroid hormone receptors (TRs). However, th

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