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Computational Insight into the Activation Mechanism of Carcinogenic N’-Nitrosonornicotine Catalyzed by Cytochrome P450

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Date of Publication : 2018-01-01

Journal : Environmental Science & Technology

Affiliation of Author(s) : 林红军

Document Type : 期刊

Volume : Vol.52

Issue : No.20

Page Number : 11838-11847

ISSN : 0013-936X;1520-5851

Abstract : Tobacco-specific N′-nitrosonornicotine , a genotoxic nitrosamine classified as Group 1 carcinogen, is also present in atmospheric particulate matter and has even been detected as a new disinfection byproduct in wastewaters. NNN generally requires metaboli

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