• Gender:Male
• Education Level:Graduate student graduate
• Alma Mater:中国科学院遗传与发育生物学研究所
• Academic Titles:生物学科负责人
• Degree:Doctorate
• Status:在岗
• School/Department:生命科学学院
• Date of Employment:2013-12-10
• Discipline:Biotechnology Bioscience
• Business Address:浙江师范大学10幢107室
• E-Mail:a1f5da27272022116438491a290d5ad50045330d0b52e5e4cc89c154d32c60c94490d7af711a54a4e57615b5c07c92517352bf033911281e607cbf6438d037da0471aba108c396de59b857be05132ef3257551ff7eccc54902f07ba7c6cfc283d617e06625d2ca8a97153915a0411b8ba7bc79935fb66d3879a1cbde50ea4187

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张可伟，教授，博/硕士生导师。2006年于中科院遗传发育所获博士学位。2006-2009年在美国康奈尔大学开展博士后研究，2009-2013年在美国布鲁克海文国家实验室任研究员助理。2013 年12月起任浙江师范大学特聘教授，先后入选国家级青年人才、浙江省“钱江学者”特聘教授、浙江省杰青、浙江省高层次人才和151人才（第一层次）等项目。主要从事植物激素与生长发育调控机理研究和应用。在Nature、Nat Commun、PNAS、Molecular Plant、Plant Cell等国际主流期刊发表论文50多篇。主持国家重点研发项目子课题、国家自然科学基金面上项目等国家和省部级课题10余项。兼任中国植物生理与植物分子生物学会理事、植物衰老与后熟专业委员会委员、浙江师范大学学术委员会委员。 担任Nature 旗下npj Science of Plants期刊副主编， Journal of Plant Growth Regulation 等期刊编委。研究方向:植物激素与生长发育调控机理研究与应用以模式植物拟南芥和农作物水稻为实验材料，研究植物激素代谢、运输和信号转导在植物生长发育（衰老）过程中的作用机理，揭示重要农艺性状的分子调控机理，探索作物改良的新途径。主要包括以下内容：1. 植物（叶片）衰老调控机理研究：植物衰老是基本的生命现象，与作物产量、品质以及抗逆密切相关。植物衰老进程受碳氮平衡和环境胁迫的协同调控，激素在其中发挥核心功能，其中细胞分裂素起正调控作用，而水杨酸起负调控作用。我们拟通过研究这两种激素调控植物衰老的信号途径，深入了解激素调控植物衰老的分子机理，进一步深入研究碳氮平衡和环境胁迫对植物衰老和作物产量的调控。通过正向遗传学克隆控制水稻叶片衰老的关键基因，鉴定在品种之间存在功能多样性的等位基因，获得能用于品种改良的种质资源。2. 植物激素代谢途径研究：植物激素代谢与运输决定激素的时空分布和区域浓度，是激素信号途径调控的重要方式。我们主要关注细胞分裂素和水杨酸：细胞分裂素是一种重要的植物生长相关激素，与作物产量关系密切，我们重点研究不同形式细胞分裂素的合成和代谢，鉴定能促进植物生长发育的重要基因。水杨酸一种重要的抗逆激素，我们以水稻和拟南芥为研究材料研究水杨酸代谢的生化路径和调控，阐明其在植物生长发育和环境适应中的调控机理。3. 植物激素运输机制研究：植物激素的合成和发挥功能的部位往往不同。激素在合成后，需要经过复杂的运输途径将激素从合成部位运输到受体结合部位。我们的研究兴趣在于鉴定细胞分裂素、水杨酸、脱落酸等激素的转运蛋白并解析其运输途径，阐明其在植物生长发育中的作用机理。4.植物激素与作物分子设计育种：将激素调控植物生长发育和逆境适应性的理论应用于作物分子设计育种，通过优异等位基因发掘、基因编辑、合成生物学等手段开展作物定向分子育种研究，致力于解决作物生长与抗逆拮抗的瓶颈问题，为培育顺境高产，逆境稳产的智慧作物新品种提供新策略。代表性科研项目：1．国家自然科学基金面上项目：32470365、高温诱导水稻叶片早衰基因 HTS6 的功能鉴定和作用机理解析 （在研）2. 浙江省自然科学基金重点项目：LZ23C020001、氮信号通过水杨酸途径调控叶片衰老的分子机理研究 （在研）3. 浙江师范大学首届高水平创新团队建设项目：植物激素与生长发育调控机理研究（在研）4. 国家重点研发计划育种专项子课题：2016YFD010091、细胞分裂素调控水稻产量的分子机理和应用 （结题）5．国家自然科学基金面上项目：31670277、水杨酸羟基化调控水杨酸动态平衡的分子机理 （结题）6．国家自然科学基金面上项目：31470370、拟南芥ABCG14细胞分裂素转运复合体的鉴定和作用机理研究（结题）7．浙江省杰出青年基金：LR15C020001、水杨酸5-羟基化酶S5H的鉴定及其在叶片衰老和抗病过程中的功能研究 （结题） 代表论文（通讯作者/第一作者）1. Zhu B, Zhang YJ* , Gao R, Wu ZH, Zhang W, Zhang C, Zhang PH, Ye C, Yao LB, Jin Y, Mao H, Tou PY, Huang P, Zhao JZ, Zhao Q, Liu C-J*, Zhang KW*. Complete biosynthesis of salicylic acid from phenylalanine in plants. Nature, 2025.7.23 on line, (https://doi.org/10.1038/s41586-025-09175-9), in press2. Zhang W, Tang SF, Li XY, Chen YY, Li JJ, Wang YY, Bian RC, Jin Y, Zhu XX, and Zhang KW*. Arabidopsis WRKY1 promotes monocarpic senescence by integrative regulation of flowering, leaf senescence, and nitrogen remobilization. Molecular Plant, 2025, 17(8): 1289-1306.3. Yang Q, Deng XJ, Liu T, Qian JY, Zhang PH, Zhu EG, Wang JQ, Zhu XX, Kudoyarova G, Zhao JZ* and Zhang KW*. Abscisic acid root-to-shoot translocation by transporter AtABCG25 mediates stomatal movements in Arabidopsis. Plant Physiology, 2024, 195(1): 671-684.4. Zhao JZ, Wang JQ, Liu J, Zhang, PH, Kudoyarova G, Liu C-J and Zhang KW*. "Spatially distributed cytokinins: Metabolism, signaling, and transport." Plant Communications, 2024, 5(7): 100936.5. Zeng WZ, Zhang YJ, Tian XY, Li WY, Meng H, Zhou, YC, Wang ZY. Chen ZC, Zhang KW* and Wang M*. Increased cytoplasmic Mg2+ level contributes to rice salicylic acid accumulation and broad-spectrum resistance. Plant Physiology, 2024, 195(4): 2515-2519.6. Miao YJ, You HL, Liu HX, Zhao YZ, Zhao, JZ, Li YF, Shen Y, Tang D, Liu BH, Zhang KW* and Cheng ZK*. "RETINOBLASTOMA RELATED 1 switches mitosis to meiosis in rice." Plant Communications, 2024, 5(6): 100857. 7. Sun X, Zhao JZ, Wu CS, Zhang KW* and Cheng L* . Flavin mononucleotide regulated photochemical isomerization and degradation of zeatin. Organic & Biomolecular Chemistry, 2024, 22(10): 2021-2026.8. Zhang PH, Zhao JZ, Zhang W, Guo YF and Zhang KW*. Sulfated peptides: key players in plant development, growth, and stress responses. Frontiers in Plant Science, 2024, 15: 1474111.9. Huang P, Zhao JZ, Hong JL, Zhu B, Xia S, Zhu, EG, Han P, and Zhang KW* . Cytokinins regulate rice lamina joint development and leaf angle. Plant Physiology, 2023, 191, 56-69.10. Zhao JZ, Deng XJ, Qian JY, Liu T, Ju M, Li JJ, Yang Q, Zhu, XX, Li W, Liu C-J, Jin ZG, and Zhang KW*. Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladenine-type cytokinins. Plant Communications, 2022,100468.11. Zhang YJ, Yu QL, Gao SP., Yu NN, Zhao L, Wang JB., Zhao JZ, Huang P, Yao LB, Wang M*., and Zhang KW*. Disruption of the primary salicylic acid hydroxylases in rice enhances broad-spectrum resistance against pathogens. Plant, Cell & Environment, 2022, 45, 2211-2225.12. Cai ZL, Guo H, Shen SQ, Yu QL, Wang JB, Zhu EG., Zhang PH, Song LL, Zhang YJ*, and Zhang KW*. Generation of the salicylic acid deficient Arabidopsis via a synthetic salicylic acid hydroxylase expression cassette. Plant Methods, 2022, 18, 89.13. Guo YF#, Ren, GD#, Zhang, KW#, Li, ZH.#, Miao Y*, and Guo HW*. Leaf senescence: progression, regulation, and application. Molecular Horticulture, 2021, 1：5 (ESI高被引论文)14. Zhao JZ, Ding BL, Zhu EG, Deng XJ, Zhang MY, Zhang PH, Wang L, Dai YS, Xiao S, Zhang CK, Liu C-J, and Zhang, KW*. Phloem unloading via the apoplastic pathway is essential for shoot distribution of root-synthesized cytokinins. Plant Physiology, 2021, 186, 2111-2123. （Faculty 1000 推荐https://facultyopinions.com/article/740013531）15. Zhao JZ, Ju M, Qian JY, Zhang MY, Liu T, Zhang KW*. A tobacco syringe agroinfiltration-based method for a phytohormone transporter activity assay using endogenous substrates, Frontiers in Plant Science, 2021, 12: 660966.16. Zhang W#, Peng KX#, Cui FB#, Wang DL, Zhao JZ, Zhang YJ, Yu NN, Wang YY, Zeng DL, Wang YH, Cheng ZK, Zhang KW*. Cytokinin oxidase/dehydrogenase OsCKX11 coordinates source and sink relationship in rice by simultaneous regulation of leaf senescence and grain number. Plant Biotechnology Journal, 2021, 19(2):335-350.17. Zhang MY, Ding BL, Zhao JZ, Zhang PH, Li YJ, Yang GD, Zhang KW*. A fluorescence-based high-throughput screening method for cytokinin translocation mutants. Plant Methods,2020, 16:13418. Zhao JZ, Yu NN, Ju M, Fan B, Zhang YJ, Zhu EG, Zhang MY, and Zhang KW*. ABC transporter OsABCG18 controls the shootward transport of cytokinins and grain yield in rice. Journal of Experimental Botany，2019，70, 6277-6291.19. Zhang YJ#, Zhao L#, Zhao JZ, Li, YJ, Wang JB; Guo R, Gan S-S; Liu C-J, Zhang KW*. S5H/DMR6 encodes a salicylic acid 5-hydroxylase that fine-tunes salicylic acid homeostasis, Plant Physiology, 2017.11, 175(3): 1082-1093 (ESI高被引论文)20. Cai YH#, Zhang KW#, Kim H, Hou G, Zhang XB, Yang HJ, Feng H, Miller L, Ralph J, Liu C-J. Enhancing digestibility and ethanol yield of Populus wood via expression of an engineered monolignol 4-O-methyltransferase. Nature Communications，2016，7: 11989 （#共同第一作者）21. Zhang KW, Novak O, Wei Z., Gou MY, Zhang XB,Yu Y, Yang HJ, Cai YH, Strnad M, and Liu C-J*. Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins. Nature Communications,2014, 10.1038/ncomms4274. Faculty of 1000推荐（http://f1000.com/prime/718272723，ESI高被引论文）22. Zhang KW, Halitschke R, Yin CX, Liu C-J, Gan, S-S*. Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating SA catabolism. PNAS,2013, 110 :14807–14812.Faculty of 1000推荐（http://f1000.com/prime/718077385 ESI高被引论文）23. Zhang KW#, Bhuiya MM#, Pazo J, Miao YC, Kim, H, Ralph J and Liu, C-J*. An engineered monolignol 4-O-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis. Plant Cell, 2012, 24: 3135-3152.24. Zhang KW and Gan S-S*. An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves. Plant Physiology, 2012, 158: 961-969. (ESI高被引论文)25. Zhang KW, Xia XY, Zhang YY and Gan S-S*. An ABA-regulated and Golgi-localized protein phosphatase controls water loss during leaf senescence in Arabidopsis. Plant Journal, 2012, 69: 667-678.26. Zhang KW#, Qian Q#, Huang ZJ, Wang YQ, Li M, Hong LL, Zheng DL, Gu MH, Chu CC and Cheng ZK* GOLD HULL AND INTERNODE2 Encodes a Primarily Multifunctional Cinnamyl-Alcohol Dehydrogenase in Rice. Plant Physiology, 2006, 140: 972-9.27. Zhang, KW, Wang JM, Yang GD, Wen FJ, Cui DC; Zheng CC. Isolation of a strong matrix attachment region (MAR) and identification of its function in vitro and in vivo. Science Bulletin, 2002, 23, 1999-2006.本课题组是处于上升期的研究团队，研究课题前沿，学习机会多，学术氛围浓厚。欢迎热爱科研的有志青年（博后、博士、硕士、本科生）加入团队，共同促进植物科学的理论和应用研究。联系方式：kwzhang@zjnu.edu.cn ; 电话：0579-82290711

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