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Highly efficient and diastereoselective synthesis of 1,3-oxazolidines featuring a palladium-catalyzed cyclization reaction of 2-butene-1,4-diol derivatives and imines.

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First Author : Chen,Dongxu

Date of Publication : 2010-01-01

Journal : Tetrahedron Letters

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.51

Issue : No.39

Page Number : 5131-5133

ISSN : 0040-4039

Key Words : ASYMMETRIC-SYNTHESIS;ALLYLIC;SUBSTITUTION;3+2;CYCLOADDITION;LIGANDS;OXAZOLIDINES;AMINOHYDROXYLATION;EQUIVALENT;OLEFINS

Abstract : A palladium-catalyzed protocol for effective synthesis of 1,3-oxazolidines has been reported. This method is featured by the high diastereoselectivity (dr up to >98/2) and using the readily available 2-butene-1,4-diol derivatives and imines as substrates.

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