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A Facile Access to 3,5-Disubstituted Oxazolones Featuring a Cu-catalyzed Cyclization of N-Alkynyl tert-Butyl Carbamates

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First Author : Lu ZH

Date of Publication : 2012-01-01

Journal : Chemistry Letters

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.41

Issue : No.6

Page Number : 636-638

ISSN : 0366-7022;1348-0715

Key Words : STEREOSELECTIVE-SYNTHESIS;RADICAL CYCLIZATION;COUPLING REACTIONS;NATURAL-PRODUCTS;YNAMIDES;HALOALKYNES;EFFICIENT;ENAMIDES;DERIVATIVES;AMIDATIONS

Abstract : Using cheap and readily accessible CuCI as the catalyst, an operationally simple and efficient method for the synthesis of 3,5-disubstituted oxazolones has been realized by the cyclization of N-allcynyl tert-butyl carbamates. The reaction proceeds under m

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