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Silver-promoted trans-hydrofluorination of ynamides: a regio- and stereoselective approach to (Z)-alpha-fluorcienamides

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First Author : Che, Jianwei

Date of Publication : 2014-01-01

Journal : Tetrahedron Letters

Affiliation of Author(s) : 化学与生命科学学院

Document Type : 期刊

Volume : Vol.55

Issue : No.45

Page Number : 6240-6242

ISSN : 0040-4039

Key Words : Hydrofluorination;Ynamides;Silver fluoride;Regio- and stereoselectivity;(Z)-alpha-Fluoroenamides

Abstract : A highly regio- and stereoselective trans-hydrofluorination of N-sulfonyl ynamides has been realized with AgF as the fluorination reagent, affording (Z)-alpha-fluoroenamides in good to excellent yields. The reaction proceeds under mild reaction conditions

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