基本信息：

袁浙梁，1988年10月生， 博士，浙江师范大学“双龙学者”特聘教授，博士生、硕士生导师。2019年10月加入浙江师范大学开展独立工作。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal. 等国际知名刊物发表多篇SCI收录论文。主要研究领域为有机氟化学和自由基化学。

办公室: 11-407

邮箱：zyuan88@zjnu.edu.cn

欢迎感兴趣的同学联系交流！

研究方向：有机氟化学，自由基化学

1，新型含氟试剂的开发及应用研究

2，自由基参与的烯烃氟（氟烷基）化双官能团化反应

      3，C-H键直接氟化或者氟烷基化反应

教育及工作背景：

2023/01 –                  浙江师范大学 化学与材料科学学院  “双龙学者”特聘教授

2019/10 – 2022/12    浙江师范大学 化学与生命科学学院  “双龙学者”特聘教授

2016/08 – 2019/08    加拿大国家实验室(TRIUMF)，西蒙弗雷泽大学, 有机化学及放射性化学 博士后      

                                  后（导师： Paul Schaffer, Robert Britton 教授）

2011/09 -- 2016/06   中科院上海有机化学研究所 有机化学 专业 博士 （导师：刘国生 研究员）

2007/09 -- 2011/06   浙江师范大学初阳学院 化学 专业 理学学士

主讲课程：

《金属有机化学》、《有机合成》、《有机实验》《有机化学》

最近以及代表性论文：

25.   Feng, B.;⁺ Tang, M.;⁺ Xiao, R.;⁺ Wang, Q.; Zhu, G.; Zhang, Z.; Yuan, Z.;* Wang, Y.* Photocatalytic Three-Component Reductive Coupling Synthesis of gem-Difluorohomoallyl Secondary Amines. J. Org. Chem. 2025, 90, 2118. 

24.  Tang, M.; Feng, B.; Bao, Y.; Xu, Z.; Huang, C.; Zheng, H.; Zhu, G.; Wang,Y.;* Yuan, Z.* Photocatalytic C(sp³)-H gem-Difluoroallylation and Alkylation with Alkenes via a Base-Assisted Formal 1,2-Hydrogen Atom Transfer of Amidyl Radicals. Chin. J. Chem. 2024, 42, 2203. 

23. Tang, M.; Bao, Y.; Zhang, H.; Xiao, R.; Feng, B.; Yuan Z.;* Wang, Y.*  Decatungstate Catalyzed Benzylic C-H Trifluoromethylthiolation. Eur. J. Org. Chem. 2024, 27, e202400346. 

22. Yuan, Z.;* Britton, R. * Development and application of decatungstate catalyzed C–H ¹⁸F- and ¹⁹F-fluorination, fluoroalkylation and beyond. Chem. Sci. 2023, 14, 12883.

21. Gao, Y.; Xiao, R.; Feng, B.; Bian, Z.; Zhang, H.; Zhu, G.; Wang, Y.;* Yuan, Z.*  Metal-free Lewis Acid-catalyzed Divergent Trifluoromethylselenolation of Alkynes: Construction of α-Trifluoromethylselenolated Ketones and Trifluoromethylselenolated Alkynes. Org. Chem. Front. 2023, 10, 4905-4911. 

20. Gao, Y.; Xiao, R.; Zhang, S.; Wang, Y.;* Yuan, Z.* Direct Trifluoromethylselenolation and Fluoroalkylselenolation of C-H Bonds: Recent Advances in Reagents Development and Reactions. Eur. J. Org. Chem. 2023, 26, e202300668. 

19. Zhang,.S.; Gao, Y.; Xiao, R.; Li, Y.; Wang, Y.;* Yuan, Z.* Tf₂O-Catalyzed Tandem Cyclization/Trifluoromethylselenolation of Alkynes for Synthesis of CF₃Se-Containing Heterocycles. Chem. Eur. J.  2023, 29, e202301283. 

18. Li, Y.; Zhang, S.; Wang, Y.; Gao, Y.; Chen, C.; Yuan. Z.* Lewis Acid Promoted Vicinal Oxytrifluoromethylselenolation of Alkenes. Org. Lett. 2023, 25, 3210.

17. Wharton, L.; McNeil, S. W; Merkens, H.; Yuan, Z.; Van de Voorde, M.; Engudar, G.; Ingham, A.; Koniar, H.; Rodriguez-Rodriguez, C.; Radchenko, V.; Ooms, M.; Kunz, P.; Benard, F.; Schaffer, P.; Yang, H.* Preclinical Evaluation of [^155/161Tb]Tb-Crown-TATE—A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours. Molecules 2023, 28, 3155. 

16. Bao, Y.; Tang, M.; Wang, Q.; Cao, Z.-Y.; Wang, Y.;* Yuan, Z.* Visible-Light-Induced Monofluoroalkenylation and gem-Difluoroallylation of Inactivated C(sp3)-H Bonds via 1,5-Hydrogen Atom Transfer (HAT). J. Org. Chem. 2023,  88, 3883.

15. Le, S.; Li, J.; Feng, J.; Zhang, Z; Bai, Y; Yuan, Z.; Zhu, G.* [3+2] Cycloaddition of alkyl aldehydes and alkynes enabled by photoinduced hydrogen atom transfer. Nat. Commun. 2022, 13, 4734.

14. Wang, Q.; Yue, L.; Bao, Y.; Wang, Y.; Gao, Y.; Yuan, Z.* Oxalates as Activating Groups for Tertiary Alcohols in Photoredox-Catalyzed gem-Difluoroallylation To Construct All-Carbon Quaternary Centers. J. Org. Chem. 2022, 87, 8237.

13. Li, Y.; Wang, Y.; Ye, Z.; Zhang, S.; Ye, X.; Yuan, Z.* Trifluoromethyl Selenoxides: Electrophilic Reagents for C–H Trifluoromethylselenolation of (Hetero)Arene. Org. Lett. 2022, 24, 3009. （Highlighted by CBG公众号、化学与材料科学公众号）

12. Wang, Y.; Bao, Y.; Tang, M.; Ye, Z.; Yuan, Z.;* Zhu, G. Recent Advances in Difunctionalization of Alkenes Using Pyridinium Salts as Radical Precursors. Chem. Commun. 2022, 58(24), 3847. (高被引论文)

11. Ye, Z.; Lei, Z.; Ye, X.; Zhou, L.; Wang, Y.; Yuan, Z.;* Gao, F.;* Britton, R.* Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process. J. Org. Chem. 2022,  87, 765.

10. Shen, J.; Wu, Z; Liu, Y.; Bai, Y.; Qiu, J.; Zhang, Z.; Yuan, Z.; * Zhu, G.* Radical Chain Isomerization of N-Sulfonyl Ynamides to Ketenimines and Its Application to Furan Dearomatization. Org. Lett. 2021, 23, 9321.

9. Zhang, H.; Wang, Q.; Wang, Y.; Yuan, Z.;* Gao, F.;* Britton, R.* Selective Trifluoromethylthiolation of Unactivated C(sp3)−H Bonds Enabled by Excited Ketones. Asian J. Org. Chem. 2021, 10, 2566.

8. Zhou, G.; Su, J.; Shang, T.; Wang, X.; Bai, Y.;* Yuan, Z.;* Zhu, G.* Synthesis of polysubstituted azetidines via cascade trifluoromethylation/cyclization of N-allyl ynamides. Org. Chem. Front. 2021, 8,  4473.

7. Wang, Y.; Ye, Z.; Zhang, H; Yuan, Z.* Recent Advances in the Development of Direct Trifluoromethylselenolation Reagents and Methods. Adv. Synth. Catal. 2021, 363, 1835.

6. Yang, H.; Zhang, C.; Yuan, Z.; Rodriguez-Rodriguez, C.; Robertson, A.; Valery Radchenko, V.; Perron, R.; Gendron, D.; Causey, P.; Gao, F.; * Bénard, F.; *Paul Schaffer, P. * Synthesis and Evaluation of  a Macrocyclic Actinium-225 Chelator, Quality Control and In Vivo Evaluation of ²²⁵Ac-crown-aMSH Peptide. Chem. Eur. J. 2020, 26, 11435.

5. Yuan, Z.; Yang, H.; Malik, N.; Čolović, M.; Weber, D. S.; Wilson, D.; Bénard, F.; Martin, R. E.;. Warren, J. J.; Schaffer, P.; Britton, R. * Electrostatic Effects Accelerate Decatungstate-Catalyzed C−H Fluorination Using [¹⁸F]- and [¹⁹F]NFSI in Small Molecules and Peptide Mimics. ACS Catal. 2019, 9, 8276.

4. Yuan, Z.;  Nodwell, M. B.; Yang, B.; Malik, N.; Merkens, H.; Bénard, F.; Martin, R. E.; Schaffer, P.;* Britton, B.* Site‐Selective, Late‐Stage C−H ¹⁸F‐Fluorination on Unprotected Peptides for Positron   Emission Tomography Imaging , Angew. Chem. Int. Ed. 2018, 57, 12733.

3. Nodwell, M. B.; Yang, H.; Colovic, M.; Yuan, Z.; Merkens, H.; Martin, R. E.;* Bénard, F.;* Schaffer, P.;* Britton, R.*¹⁸F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids:  Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents. J. Am. Chem. Soc. 2017, 139, 3595.

2. Yuan, Z.; Cheng, R.; Chen, P.; Liu, G.;* Liang, S.* Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines. Angew. Chem. Int. Ed.  2016, 55, 11882.

1. Yuan, Z.; Wang, H-Y.; Mu, X.; Chen, P.; Guo, Y-L.; Liu, G.* Highly Selective Pd-Catalyzed Intermolecular Fluorosulfonylation of Styrenes. J. Am. Chem. Soc. 2015, 137, 2468.

授权专利：

1，氟标记的异喹啉类化合物及其制备方法。刘国生，梁欢，袁浙梁，程然，陈品红。专利号：ZL2016106976810

2，¹⁸F\Labelled Amino Acids, Derivatives Thereof and Method of Making Same. Schaffer Paul，Yang Hua, Britton Robert, Nodwell Matthew, Yuan Zheliang. 专利号：WO 2018/035610 A.

主持科研项目：

1，浙江省自然科学基金青年科学基金项目，2020—2022，结题。

2，浙江师范大学高层次人才引进启动经费，2020—2022。

3，国家自然科学基金青年项目，2021-2023，结题。