徐晓虹
professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Gender : Female
Alma Mater : 浙江大学
Education Level : Graduate student graduate
Degree : Doctorate
Status : 退休
School/Department : 生命科学学院
Date of Employment : 1984-07-01
Discipline : Bioscience Biotechnology
Contact Information : 13505791471
Email :
Hits :
First Author : 李涛
Affiliation of Author(s): 化学与生命科学学院
Date of Publication : 2010-01-01
Document Type : 期刊
Journal : 中国生物化学与分子生物学报
Issue : 第5期
Page Number : 411-417
ISSN : 1007-7626
Translation or Not : no
Key Words : 丝裂原和应激激活的蛋白激酶；丝裂原激活蛋白激酶；表观遗传学调控；组蛋白磷酸化；转录调控
Abstract : 丝裂原和应激激活的蛋白激酶(MSK)是一类核内丝/苏氨酸蛋白激酶,参与丝裂原激活蛋白激酶(MAPK)信号通路介导的下游基因转录调控和表观遗传学调控.首先,MSK是MAPK通路的下游媒介分子.在丝裂原或应激刺激下,p38或ERK激酶通过级联磷酸化激活MSK蛋白.然后,活化的MSK介导转录因子磷酸化活化和组蛋白H3的10位丝氨酸磷酸化.MSK介导的组蛋白H3磷酸化,可引发组蛋白乙酰化和甲基化修饰的动态变化,相互协同或拮抗,开放染色质结构,利于诱导型基因的表达.除组蛋白H3外,MSK直接磷酸化的下游底物还包括C
徐晓虹
教授，博士，硕士生导师。
主要研究方向：学习记忆的神经生物学机制和环境内分泌干扰物对脑和行为发育的影响。
近几年承担的研究课题：
1主持国家自然科学基金项目（2018~2021）：青春期双酚A暴露对社会行为的影响及其神经机制
2主持国家自然科学基金项目（2015~2018）：双酚A对雄激素调节神经行为和突触可塑性的影响及其机制研究
3主持国家自然科学基金项目（2012~2015）：双酚A对成年神经行为和突触可塑性的影响及其机制研究
4主持国家自然科学基金项目（2009~2011）：双酚A对发育中脑内NMDA受体的影响及其机制研究
5主持国家自然科学基金项目（2008）：双酚A对发育中脑内NMDA受体的影响
6主持省自然科学基金重点项目（2010~2013）：环境雌激素对神经元树突发育和突触发生的影响
近几年代表性学术论文：
1Yang Yang, Zhaoqing Fang, Yuhua Dai, Yu Wang, Yufeng Liang, Xiaoyu Zhong,Qinwen Wang, Yizhong Hu, Zigui Zhang, Donghong Wu, Xiaohong Xu*. Bisphenol-A antagonizes the rapidly modulating effect of DHT onspinogenesis and long-term potentiation of hippocampal neurons. Chemosphere 2018，195: 567-575
2Zhaoqing Fang, Qingjie Zhu, Ting Gu, Xiuying Shen, Yang Yang, Yufeng Liang, Zigui Zhang,Xiaohong Xu*. Anti-androgenic effects of bisphenol-A on spatial memory and synaptic plasticity of the hippocampus in mice. Hormones & Behavior. 2017, 93:151-158
3Xiaowei Chen, Yu Wang, Fang Xu, XiaofeiWei, Junfang Zhang,Chuang Wang, HuaWei, Shujun Xu, Peiyun Yan, Wenhua Zhou, Istvan Mody,Xiaohong Xu*, QinwenWang*. The rapid effect of bisphenol-A on long-term otentiation inhippocampus involves estrogen receptors and erk activation. Neural Plasticity. 2017,
4Ran Wang, Xiaohong Xu*, Huifang Weng, Shengyao Yan, Yangyang Sun. Effects of early pubertal exposure to di-(2-ethylhexyl) phthalate on social behavior of mice. Hormones and Behavior. 2016, 80, 117-124
5Ran Wang, Xiaohong Xu*, Qingjie Zhu. Pubertal exposure to di-(2-ethylhexyl) phthalate influences social behavior and dopamine receptor D2 of adult female mice. Chemosphere, 2016, 144, 1771-1779
6Yuhua Dai, Yanling Yang, Xiaohong Xu*, Yizhong Hu. Effects of uterine and lactational exposure to di-(2-ethylhexyl) phthalate on spatial memory and NMDA receptor of hippocampus in mice. Hormones and Behavior. 2015, 71, 41-48
7Xiaohong Xu*Yanling Yang, Ran Wang, Yu Wang, Qin Ruan, Yang Lu. Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice. Chemosphere, 2015, 124, 22-31
8Xiaohong Xu*,Ting Gu, Qiaoqiao Shen. Different effects of bisphenol-A on memory behavior and synaptic modification in intact and estrogen-deprived female mice. J Neurochemistry, 2015, 132(5), 572-582.
9Xiaohong Xu*,Fangni Dong, Yanling Yang,Yu Wang, Ran Wang, Xiuying Shen. Sex-specific effects of long-term exposure to bisphenol-A on anxiety- and depression-like behaviors in adult mice. Chemosphere, 2015, 120, 258-266
10Xiaohong Xu*,Yang Lu, Guangxia Zhang, Lei Chen, Dong Tian, Xiuying Shen, Yanling Yang, Fanni Dong. Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway. Chemosphere, 2014; 96(8):129-1372月
11Qin Zhang, Xiaohong Xu*,Tao Li, Yang Lu, Qin Ruan, Yingjun Lu, Qinwen Wang, Fangni Dong, Yanling Yang, Guangxia Zhang. Exposure to bisphenol-A affects fear memory and histone acetylation of the hippocampus in adult mice. 2014, 65(2):106–113.
12Xiaohong Xu*,Yang Lu, Guangxia Zhang, Lei Chen, Dong Tian, Xiuying Shen, Yanling Yang, Fanni Dong. Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway. Chemosphere, 2014; 96(8):129-137
13Xiaohong Xu*, Xingyi Liu, Qin Zhang, Guangxia Zhang, Yingjun Lu, Qin Ruan, Fangni Dong, Yanling Yang. Sex-specific effects of bisphenol-A on memory and synaptic structural modification in hippocampus of adult mice. Hormones and Behavior 2013; 63:766–775.
14Xiaohong Xu*, Lingdan Xie, Xing Hong, Qin Ruan, Hongfei Lu, Qin Zhang, Guangxia Zhang, Xingyi Liu. Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice. Chemosphere, 2013; 91(8):1073-1081
15Xiaohong Xu*, Xing Hong, Lingdan Xie, Tao Li, Yujie Yang, Qin Zhang,Guangxia Zhang, Xingyi Liu. Gestational and lactational exposure to bisphenol-A affects anxiety- and depression-like behaviors in mice.Horm & Behav, 2012; 62:480-490
欢迎有志从事神经毒理学研究的同学报考！
联系方式：13505791471, 661471(短号)
电子邮件：xuxh63@zjnu.cn
