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First Author : Lin, Clement

Date of Publication : 2018-01-01

Journal : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affiliation of Author(s) : 物理化学研究所

Document Type : 期刊

Volume : Vol.57

Issue : No.34

Page Number : 10888-10893

ISSN : 1433-7851

Key Words : anticancer drug targets;G4-drug complexes;human telomeres;G-quadruplexes;NMR spectroscopy;berberine

Abstract : Human telomeres can form DNA G-quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal n

Translation or Not : no