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Recognition of DNA abasic site nanocavity by fluorophore-switched probe: Suitable for all sequence environments.

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First Author : Wang, Ying

Date of Publication : 2016-01-01

Journal : Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy

Affiliation of Author(s) : 物理化学研究所

Document Type : 期刊

Volume : Vol.153

Page Number : 645-650

ISSN : 1386-1425

Key Words : Abasic;site;Fluorescence;enhancement;Isoquinoline;alkaloids;Molecular;recognition;Nucleic;acid;Palmatine

Abstract : Removal of a damaged base in DNA produces an abasic site (AP site) nanocavity. If left un-repaired in vivo by the specific enzyme, this nanocavity will result in nucleotide mutation in the following DNA replication. Therefore, selective recognition of AP

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