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Human telomeric hybrid-2-over-hybrid-1 G-quadruplex targeting and a selective hypersaline-tolerant sensor using abasic site-engineered monomorphism.

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First Author : Wu T

Date of Publication : 2017-01-01

Journal : Analytica Chimica Acta

Affiliation of Author(s) : 物理化学研究所

Document Type : 期刊

Volume : Vol.964

Page Number : 161-169

ISSN : 0003-2670

Key Words : Abasic;site;Fluorescent;sensor;Human;telomeric;G-quadruplex;Hybrid-1/Hybrid-2;Hypersaline;Selectivity

Abstract : Coexistence of the polymorphic hybrid-1 and hybrid-2 conformers for a given human telomeric G-quadruplex-forming sequence (htG4) complicates its fine structure identification and limits its application as a sensor element. With help from abasic site (AP s

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