钱兆生博士，教授，“双龙学者”特聘教授，博士生导师，浙江省杰出青年基金获得者，中国化学会高级会员。2009.6月南京大学化学化工学院化学专业获理学博士学位，博士论文曾获2011年度全国优秀博士学位论文提名论文。2009.8起在浙江师范大学分析化学学科开展分析化学教学工作和相关科研工作。2013-2014年由国家公派到美国华盛顿大学(James R. Mayor课题组)做访问研究一年。目前主要从事于新型荧光分子探针的设计合成、靶向检测与精准成像研究，以及高端生物靶向荧光染料的设计合成及应用研究。主持完成国家自然科学基金青年基金、面上项目、浙江省杰出青年基金、重点项目等多项自然科学基金，主持完成一项横向项目；研究成果发表在《Journal of American Chemical Society》、《Chemical Science》(3篇)、《Chemical Communications》(8篇)、《Analytical Chemistry》(14篇)、《Chemistry-A European Journal》(8篇)、《Advanced Optical Materials》、《Journal of Physical Chemistry Letters》(3篇)、《Biosensors and Bioelectronics》(7篇)、《ACS Sensors》、《ACS Applied Materials & Interfaces》(4篇)、《Analyst》(3篇)、《Journal of Materials Chemistry C》(13篇)、《Journal of Materials Chemistry B》(4篇)、《Sensors and Actuators B Chemical》(9篇)等国际学术刊物上共130多篇，受邀在《Journal of Materials Chemistry C》上发表邀请综述两篇，在《The Chemical Record》发表邀请综述一篇，5篇文章被选为封面文章。h-index 42，单篇最高引用次数为449次，总引用次数近6300余次。申请国家发明专利十余件，授权7件，成功研发细胞质膜长时间成像染料FM2.0系列和细胞质膜MemTracker系列，已在北京百灵威科技有限公司上市销售。曾获2017年度浙江省自然科学奖三等奖、2018年度化学学科“Publons同行评议奖”、入选2021年-2025年全球前10万名学者学术影响力排行榜（全球前2%顶尖科学家终身影响力和年度影响力排行榜）。

目前指导研究生十名，已毕业研究生四十余名，考取浙江大学等985高校十余名，指导研究生曾获研究生国家奖学金、耿儿奖学金、学校科学创新一等奖和二等奖、浙江省优秀研究生学位论文、校级优秀研究生学位论文等。

主要研究方向

1. 新型荧光分子探针的设计合成、靶向检测与精准成像：基于生物正交化学和配体导向共价标记等前沿技术，系统设计并构建具有优异靶向性能和高精准度的新型荧光分子探针，重点研究细胞器靶向荧光分子探针的设计及在生物精准成像应用，开发新型细胞器靶向成像染料。

2. 生物靶向荧光染料：发展受体靶向的荧光分子探针，深入探索其在细胞和活体内荧光标记和示踪潜力，开发用于癌症等重大疾病辅助诊断、精准成像和荧光导航手术的新型分子光学探针。

发表学术论文

(122) Shuyi Jiang, Ruihan Jiang, Xin Peng, Chuixi Kong, Tian Li, He Zhao, Jin Zhou, Hui Feng,* Zhigang Jin,* Zhaosheng Qian*. Electronic-directed covalent labeling of pan-membrane proteins for ultralong-term tracking of plasma membrane dynamics. Anal. Chem., 2025, DOI:10.1021/acs.analchem.5c05243.

(121) Junjun Pan, Aohui Peng, Shuyi Jiang, Xin Peng, Chuixi Kong, Jin Zhou, Hui Feng,* Zhigang Jin,* Zhaosheng Qian*. Dual-Anchoring fluorescent probes enables facile recognition of pyroptosis through dynamic tracking of plasma membrane. Anal. Chem., 2025, 97, 16995-17003.

(120) Xin Peng, Chuixi Kong, Shuyi Jiang, Yingye Weng, Xinyue Shi, Hui Feng,* Weidong Liu, Jin Zhou, Zhigang Jin,* Zhaosheng Qian*. High-fidelity tracking of endocytosis in cancer cells under cellular stress using a long-term anchoring cell membrane fluorescent probe. Anal. Chem., 2025, 97, 15780-15789.

(119) Zhengdong Han, Tian Li, Ziqing He, Engao Zhu, Zhaosheng Qian*, Xia Liu,* Hui Feng*. Modular design of membrane-impermeable versatile probe for specific imaging of cell walls and real-time detection of cell membrane damage. Anal. Chem., 2025, 97, 8109-8119.

(118) Penglei Wu, Jiaqi Zuo, Zhengdong Han, Xin Peng, Ziqing He, Wenjing Yin, Hui Feng,* Engao Zhu, Yuchun Rao,* Zhaosheng Qian*. Green fluorescent FM dyes with prolonged retention for 4D tracking of plasma membrane dynamics in live plants under environmental stress. Biosens. Bioelectron., 2025, 271, 117039.

(117) Xin Peng, Junjun Pan, Zhengdong Han, Penglei Wu, Ziqing He, Hui Feng,* Weidong Liu, Kewei Zhang, Engao Zhu,* Zhaosheng Qian*. Three-dimensional tracking of organ development in live plants based on plasma membrane dyes at single-cell resolution. Spectrochim. Acta A, 2025, 329, 125575.

(116) Chuangye Yao, Aohui Peng, Penglei Wu, Jiaqi Zuo, Junjun Pan, Chuixi Kong, Zhaosheng Qian, Zhigang Jin,* Hui Feng*. Side-chain-engineered fluorescent dyes for 3D and long-term dynamic tracking of the plasma membrane in living cells. Talanta, 2024, 279, 126583.

(115) Yuzhen Wu, Jaile Zhan, Zhengdong Han, Weidong Liu, Zhaosheng Qian, Hui Feng*. Multicolor AIE-active photoswitches with improved fatigue resistance by introducing asymmetric photoactive units. J. Mater. Chem. C, 2024, 12, 2552−2560.

(114) Junjun Pan, Xin Peng, Chuangye Yao, Jiaqi Zuo, Tingting Lei, Hui Feng, Kewei Zhang, Engao Zhu,* Zhaosheng Qian*. Target-activated multicolor fluorescent dyes for 3D imaging of plasma membranes and tracking of apoptosis. J. Mater. Chem. B, 2024, 12, 2761−2770.

(113) Chuangye Yao, Jiaqi Zuo, Penglei Wu, Jie Liu, Junjun Pan, Engao Zhu, Hui Feng, Kewei Zhang,* Zhaosheng Qian*. Molecular engineering of fluorescent dyes for long-term specific visualization of the plasma membrane based on alkyl-chain-regulated cell permeability. Talanta, 2024, 275, 126105.

(112) Jiaqi Zuo, Aohui Peng, Penglei Wu, Junyi Chen, Chuangye Yao, Junjun Pan, Engao Zhu, Yingye Weng, Kewei Zhang, Hui Feng, Zhigang Jin,* Zhaosheng Qian*. Charge-regulated fluorescent anchors enable high-fidelity tracking of plasma membrane dynamics during biological events. Chem. Sci., 2024, 15, 8934−8945.

(111) Jiale Zhan, Chuangye Yao, Zhengdong Han, Yuzhen Wu, Hui Feng,* Zhaosheng Qian*. Fluorescent photoswitches with improved emission efficiency based on aggregation-induced emission luminogens by eliminating the heavy-atom effect. J. Mater. Chem. C, 2024, 12, 3498−3505.

(110) Yuzhen Wu, Xinni Ping, Chuangye Yao, Penglei Wu, Zhengdong Han, Xin Peng, Jiale Zhan, Hui Feng,* Zhaosheng Qian*. Photoinduced fluorescence modulation through controllable intramolecular [2+2] photocycloaddition in single molecules and molecular aggregates. Chem. Commnu., 2024, 60, 1301−1304.

(109) Yuqing Zhu, Xinni Ping, Xiangting Wang, Xuting Cai, Jiaqi Zuo, Zhaosheng Qian, Hui Feng*. Fluoride-regulated colorimetric and fluorometric switch through B-F dynamic covalent reactions of AIEgens. Mol. Syst. Des. Eng., 2023, 8, 902−910.

(108) Yuqing Zhu, Yangbing Chen, Zuping Xiong, Mengyi Jiang, Hui Feng, Zhaosheng Qian*. Base-gated photochromism of C3-symmetric AIEgens through multicyano-sensitized benzene rings. Tetrahedron, 2023, 133, 133269.

(107) Shixuan An, Yanfei Lin, Jianbo Wang,* Tianqing Ye, Yanyun Mao, Jian Zhang, Longhua Guo, Lei Li, Zhaosheng Qian*, Haiying Liu*. Near-infrared mitochondria-targeted fluorescent probe with a large stokes shift for rapid and sensitive detection of cysteine/homocysteine and its bioimaging application. Sens. Actuat. B Chem., 2023, 374, 132799.

(106) Wei Yue, Bingyong Lin, Yueyue Huang, Yueliang Wang, Yuanyuan Yao, Lifen Chen, Yanbo Zeng, Lei Li, Zhaosheng Qian*, Longhua Guo*. Toxicity evaluation of MC-IR in different fish organs based on aptamer-recognized SERS tag coupled with magnetic separation. Sens. Actuct. B. Chem., 2023, 380, 133319.

(105) Yuzhen Wu, Yuqing Zhu, Chuangye Yao, Jiale Zhan, Penglei Wu, Zhengdong Han, Jiaqi Zuo, Hui Feng, Zhaosheng Qian*. Recent advances in small-molecule fluorescent photoswitches with photochromism in diverse state. J. Mater. Chem. C, 2023, 11, 15393−15411.

(104) Xinni Ping, Junjun Pan, Xin Peng, Chuangye Yao, Tian Li, Hui Feng, Zhaosheng Qian*. Recent advances in photoresponsive fluorescent materials based on [2+2] photocycloaddition reactions. J. Mater. Chem. C, 2023, 11, 7510−7525.

(103) Jiaqi Zuo, Engao Zhu, Wenjing Yin, Changye Yao, Jiajia Liao, Xinni Ping, Yuqing Zhu, Xuting Cai, Yuchun Rao, Hui Feng, Kewei Zhang*, Zhaosheng Qian*. Long-term spatiotemporal and highly specific imaging of the plasma membrane of diverse plant cells using a near-infrared AIE probe. Chem. Sci., 2023, 14, 2139−2148.

(102) Zuping Xiong, Wenqi Gong, Pengfei Xu, Mengyi Jiang, Xuting Cai, Yuqing Zhu, Xinni Ping, Hui  Feng, Huili Ma*, Zhaosheng Qian*. Reexamining the heavy-atom effect: the universal heavy-atom-induced fluorescence enhancement principle for through-space conjugated AIEgens. Chem. Eng. J., 2023, 451, 139030.

(101) Xuting Cai, Zuping Xiong, Jiale Zhan, Xinni Ping, Yuqing Zhu, Jiaqi Zuo, Hui Feng, Zhaosheng Qian*. Dramatic emission enhancement of aggregation-induced emission luminogens by dynamic metal coordination bonds and the anti-heavy-atom effect. Chem. Commun., 2022, 58, 10837−10840.

(100)  Sidan Guo, Xuting Cai, Shasha Zhou, Qiaozhi Zhu, Hui Feng Zhaosheng Qian.* Rational design of state-depending photoactivatable and photoconvertible fluorescent AIEgens through a rapid photocyclodehydrogenation reaction. Dye. Pigm., 2022, 201, 110235.

(99)  Xiaoxiao Zhang, Zhenni Wang, Hao Chu, Zuping Xiong, Yanjiang Li, Yi Chen, Qiaozhi Zhu, Hui Feng, Engao Zhu, Jin Zhou,* Peng Huang,* Zhaosheng Qian.* Antipermeability strategy to achieve extremely high specificity and ultralong imaging of diverse cell membranes based on restriction-induced emission of AIEgens. Anal. Chem., 2022, 94, 4048-4058.

(98)  Zhenni Wang, Zuping Xiong, Weidong Liu, Qiaozhi Zhu, Xiaoxiao Zhang, Yuqing Ding, Chunyan Huang, Hui Feng, Kewei Zhang, Engao Zhu,* Zhaosheng Qian.* Esterase-activated precipitating strategy to achieve highly specific detection and long-term imaging of calcium ions by aggregation-induced phosphorescence probe. Anal. Chem., 2022, 94, 5406-5414.

(97)  Xiang Hu, Ying Wang, Zuping Xiong, Pei Song, Ai-Jun Wang, Zhaosheng Qian, Pei-Xin Yuan,* Tiejun Zhao, Jiu-Ju Feng.* Novel aggregation-enhanced PEC photosensitizer based on electrostatic linkage of ionic liquid with protoporphyrin IX for ultrasensitive detection of Molt-4 cells. Anal. Chem., 2022, 94, 3708-3717.

(96)  Jianfei Kan, Xiaonan Zhou, Yanyan Sun, Liyuan Sun, Hao Chu, Zhaosheng Qian,* Jin Zhou.* Molecular engineering and biomedical applications of ultra-sensitive fluorescent probe for Ag+. Chin. Chem. Lett., 2021, 32, 3066-3070.

(95)  Zuping Xiong, Zhenni Wang, Longxiang Liu, Mengyi Jiang, Xiaoxiao Zhang, Qiaozhi Zhu, Hui Feng, Zhaosheng Qian.* Breaking classic heavy-atom effect to achieve heavy-atom-induced dramatic emission enhancement of silole-based AIEgens with through-bond and through space conjugation. Adv. Optical Mater., 2021, 9, 2101228.

(94)  Riqing Ding, Ke Qin, Huili Sun, Shasha Zhou, Sidan Guo, Hui Feng Huili Ma,* Zhaosheng Qian.* Endowing nitro-compounds with bright and stimuli-responsive luminescence based on propeller-like AIEgens. J. Mater. Chem. C, 2021, 9, 12177-12183.

(93)  Zuping Xiong, Xiaoxiao Zhang, Longxiang Liu, Qiaozhi Zhu, Zhenni Wang, Hui Feng Zhaosheng Qian.* Achieving highly efficient aggregation-induced emission, reversible and irreversible photochromism by heavy halogen-regulated photophysics and D-A molecular pattern-controlled photochemistry of through-space conjugated luminogens. Chem. Sci., 2021, 12, 10710-10723. (Cover paper)

(92)  Shasha Zhou, Sidan Guo, Weidong Liu, Riqing Ding, Huili Sun, Jianrong Chen, Zhaosheng Qian, Hui Feng.* Wavelength-dependent multicolor photochromism and fluorescence switching based on an AIE-active skeleton by regulating the conjugation of the photoactive unit. J. Mater. Chem. C, 2021, 9, 8249-8257.

(91)  Jie Zhang, Jianfei Kan, Yanyan Sun, Miae Won, Ji Hyeon Kim, Weifen Zhang, Jin Zhou,* Zhaosheng Qian, Jong Seung Kim.* Nanoliposomal ratiomeric fluorescent probe toward ONOO^- flux. ACS Appl. Bio Mater., 2021, 4, 2080-2088.

(90)  Mengru Wei, Hangqi Zhong, Jin Zhou, Weidong Liu, Wenbin Xi, Pengfei Xu, Qianqian Qiu, Zhaosheng Qian, Hui Feng.* A phosphorescence “turn-on” probe for the detection and imaging of Al3+ based on aggregation-induced emission. Talanta, 2020, 219, 121298.

(89)  Shasha Zhou, Sidan Guo, Weidong Liu, Qiaoying Yang, Huili Sun, Riqing Ding, Zhaosheng Qian, Hui Feng.* Rational design of reversibly photochromic molecules with aggregation-induced emission by introducing photoactive thienyl and benzothienyl groups. J. Mater. Chem. C, 2020, 8, 13197-13204. (Inside Cover)

(88)  Sidan Guo, Shasha Zhou, Jiajing Chen, Ping Guo, Riqing Ding, Huili Sun, Hui Feng Zhaosheng Qian.* Photochromism and fluorescence switch of furan-containing tetraarylethene luminogens with aggregation-induced emission for photocontrolled interface-involved applications. ACS Appl. Mater. Interfaces, 2020, 12, 42410-42419.

(87)  Huili Sun, Riqing Ding, Shanling Lv, Shasha Zhou, Sidan Guo, Zhaosheng Qian, Hui Feng.* Clustering-triggered ultralong room-temperature phosphorescence of organic crystals through halogen-mediated molecular assembly. J. Phys. Chem. Lett., 2020, 11, 4962-4969.

(86)  Mengru Wei, Hangqi Zhong, Jin Zhou, Weidong Liu, Wenbin Xi, Pengfeixu, Qianqian Qiu, Zhaosheng Qian, Hui Feng.* A phosphorescence turn-on probe for the detection and imaging of Al³⁺ based on aggregation-induced emisssion. Talanta, 2020, 219, 121298.

(85)  Wenbin Xi, Junru Yu, Mengru Wei, Qianqian Qiu, Pengfei Xu, Zhaosheng Qian, Hui Feng.* Controllable switching between aggregation-induced phosphorescence and dual-state emission by subtle isomerization. Chem. Eur. J., 2020, 26, 3733-3737.

(84)  Pengfei Xu, Qianqian Qiu, Xinru Ye, Mengru Wei, Wenbin Xi, Hui Feng,  Zhaosheng Qian.* Halogenated tetraphenylethene with enhanced aggregation-induced emission: anomalous anti-heavy-atom effect and self-reversible mechanochromism. Chem. Commun., 2019, 55, 14938-14941.

(83)  Guilin Chen, Zaicai Zhou, Hui Feng, Chenyan Zhang, Yifan Wang,  Zhaosheng Qian,* Jianwei Pan.* An aggregation-induced phosphorescence probe for calcium ion-specific detection and live-cell imaging in Arabidopsis thaliana. Chem. Commun., 2019, 55, 4841 - 4844.

(82)  Chenxia Zhang, Hai Xie, Tongxia Zhan, Jie Zhang, Bochao Chen, Zhaosheng Qian, Guanglu Zhang, Weifen Zhang, Jin Zhou.* A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging. Chem. Commun., 2019, 55, 9444 - 9447.

(81)  Qianqian Qiu, Pengfei Xu, Yanjun Zhu, Junru Yu, Mengru Wei, Wenbin Xi, Hui Feng, Jianrong Chen,  Zhaosheng Qian.* Rational design of dual-state emission luminogens with solvatochromism by combining a partially shared donor-acceptor pattern and twisted structures. Chem. Eur. J., 2019, 25, 15983-15987. (Inside Cover)

(80)  Guilin Chen, Sidan Guo, Hui Feng,* Zhaosheng Qian.* Anion-regulated transient and persistent phosphorescence and size-dependent ultralong afterglow of organic ionic crysltas. J. Mater. Chem. C, 2019, 7, 14535-14542. (Inside Cover)

(79)  Pengfei Xu, Zhiyi Bao, Chenyi Yu, Qianqian Qiu, Mengru Wei, Wenbin Xi,  Zhaosheng Qian, Hui Feng* A water-soluble molecular probe with aggregation-induced emission for discriminative detection of Al³⁺ and Pb²⁺ and imaging in seedling root of Arabidopsis. Spectrochim. Acta A, 2019, 223, 117335.

(78)  Saifei Pan, Jin Zhou, Weidong Liu, Yuxin Ye, Guilin Chen, Jing Xu, Zhaosheng Qian, Jianrong Chen, Hui Feng.* Viscosity-sensitive thiolated gold nanoclusters with diffusion-controlled emission for intracellular viscosity imaging. Analyst, 2019, 144, 4483 - 4487.

(77)  Guilin Chen, Hui Feng, Wenbin Xi, Jing Xu, Saifei Pan, Zhaosheng Qian.* Thiol-ene click reaction-induced fluorescence enhancement by altering the radiative rate for assaying butyrylcholinesterase activity. Analyst, 2019, 144, 559 - 566.

(76)  Guilin Chen, Jin Zhou, Hui Feng, Feifei Feng, Pengfei Xu, Saifei Pan, Jing Xu, Zhaosheng Qian.* A simple and efficient phosphorescent probe for iodide-specific detection based on crystallization-induced phosphorescence of organic ionic crystals. J. Mater. Chem. C, 2019, 7, 43 - 47.

(75)  Hang Ao, Hui Feng, Saifei Pan, Zhiyi Bao, Zhenhui Li, Jianrong Chen, Zhaosheng Qian.* Synthesis and functionalization of stable and bright copper nanoclusters by in situ gereration of silica shells for bioimaging and biosensing. ACS Appl. Nano Mater., 2018, 1, 5673 - 5681.

(74)  Guilin Chen, Hui Feng, Feifei Feng, Pengfei Xu, Jing Xu, Saifei Pan, Zhaosheng Qian.* Photophysical tuning of organic ionic crystals from ultralong afterglow to highly efficient phosphorescence by variation of halides. J. Phys. Chem. Lett., 2018, 9, 6305 - 6311.

(73)  Jing Xu, Hui Feng, Hao Teng, Guilin Chen, Saifei Pan, Jianrong Chen, Zhaosheng Qian.* Reversible switching between phosphorescence and fluorescence in a unimolecular system controlled by external stimuli. Chem. Eur. J., 2018, 24, 12773 - 12778.

(72)  Saifei Pan, Zhentian Chen, Xulian Zheng, Donghui Wu, Guilin Chen, Jing Xu, Hui Feng, Zhaosheng Qian.* Ultralong room-temperature phosphorescence from supramolecular behavior via intermolecular electronic coupling in pure organic crystals. J. Phys. Chem. Lett., 2018, 9, 3939 - 3945.

(71)  Hang Ao, Hui Feng, Keqing Li, Meizhi Zhao, Zhaosheng Qian,* Jianrong Chen*. Coordinate bonding-induced emission of gold glutathione complex for sensitive detection of aluminum species. Sens. Actuat. B-Chem, 2018, 272, 1 - 7.

(70)  Chao Che, Zhaosheng Qian, Mingchang Wu, Ying Zhao, Gangguo Zhu*. Intermolecular oxidative radical addition to aromatic aldehydes: direct access to 1,4 and 1,5-diketones via silver-catalyzed ring-opening acylation of cyclopropanols and cyclobutanols. J. Org. Chem., 2018, 83, 5665 - 5673.

(69)  Saifei Pan, Weidong Liu, Jiantao Tang, Yingjie Yang, Hui Feng, Zhaosheng Qian*, Jin Zhou*. Hydrophobicity-guided self-assembled particles of silver nanoclusters with aggregation-induced emission and their use in sensing and bioimaging. J. Mater. Chem. B, 2018, 6, 3927 - 3933.

(68)  Hui Feng, Zhaosheng Qian*. Functional carbon quantum dots: a versatile platform for chemosensing and biosensing. Chem. Rec., 2018, 18, 491 - 505. (Invited Review)

(67)  Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan, Zhaosheng Qian*. Redox-controlled fluorescent nanoswitch based on reversible disulfide and its application in butyrylcholinesterase activity assay. Anal. Chem., 2018, 90, 1643-1651.

(66)  Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng.* Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening. Sens. Actuat. B-Chem, 2018, 255, 22-28.

(65) Meizhi Zhao, Hui Feng, Xiaoxiao Zhang, Hang Ao, Zhaosheng Qian*. Bonding-Induced Emission of Silyl-Protected Copper Nanoclusters for Luminescence Turn-on Detection of Trace Water in Organic Solvents. Analyst, 2017, 142, 4613-4617. (Cover Paper)

(64) Hang Ao, Hui Feng, Mengting Zhao, Meizhi Zhao, Jianrong Chen, Zhaosheng Qian.* Redox-triggered bonding-induced emission of thiol-functionalized gold nanoclusters for luminescence turn-on detection of molecular oxygen. ACS Sens., 2017, 2, 1692-1699.

(63) Meizhi Zhao, Zhaosheng Qian(Coauthors), Mengting Zhong, Zhentian Chen, Hang Ao, Hui Feng.* Fabrication of stable and luminescent copper nanocluster-based AIE particles and their application in β-galactosidase activity assay. ACS Appl. Mater. Interfaces, 2017, 9, 32887-32895.

(62) Meizhi Zhao, Hui Feng, Jiaonan Han, Hang Ao, Zhaosheng Qian*. Multi-stimuli responsive copper nanoclusters with bright red luminescence for quantifying acid phosphatase via redox-controlled luminescence switch. Anal Chim. Acta, 2017, 984, 202-210.

(61) Yuanyuan Huang, Hui Feng, Weidong Liu, Shasha Zhang, Cong Tang, Jianrong Chen, Zhaosheng Qian,* Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for beta-galactosidase activity monitoring, J. Mater. Chem. B, 2017, 5, 5120-5127.

(60) Cong Tang, Hui Feng, Yuanyuan Huang, Zhaosheng Qian*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity. Anal. Chem. 2017, 89, 4994-5002. 

(59) Qian Sun, Siying Fang, Yafen Fang, Zhaosheng Qian, Hui Feng*. Fluorometric Detection of Cholestrol Based on beta-Cyclodextrin Functionalized Carbon Quantum Dots via Competitive Host-Guest Recognition. Talanta, 2017, 167, 513-519.

(58) Ao Hang, Hui Feng, Xiaolu Huang, Meizhi Zhao, Zhaosheng Qian*. A Reversible Fluorescence Nanoswitch Based on Dynamic Covalent B-O Bonds Using Functional Carbon Quantum Dots and Its Application for α-Glucosidase Activity Monitoring. J. Mater. Chem. C, 2017, 5, 2826-2832.

(57) Cong Tang, Jin Zhou, Zhaosheng Qian(Co-first author), Yanyan Ma, Yuanyuan Huang, Hui Feng*. A Universal Fluorometric Assay Strategy for Glycosidases Based on Functional Carbon Quantum Dots: ß-Galactosidase Activity Detection in vitro and in Living Cells. J. Mater. Chem. B, 2017, 5, 1971-1979.

(56) Cong Tang, Zhaosheng Qian(Co-first author), Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng*. A Fluorometric and Real-time Assay for α-Glucosidase Activity Through Supramolecular Self-assembly and Its Application for Inhibitor Screening. Sens. Actuat. B-Chem., 2017, 245, 282-289.

(55) Hong Huang, Hua Li, Jiuju Feng, Hui Feng, Aijun Wang,* Zhaosheng Qian.* One-pot green synthesis of highly fluorescent glutathione-stabilized copper nanoclusters for Fe³⁺ sensing. Sens. Actuat. B-Chem. 2017, 241, 292-297.

(54) Aijun Wang, Hua Li, Hong Huang, Zhaosheng Qian, Jiuju Feng*. Fluorescent graphene-like carbon nitrides: synthesis, properties and applications, J. Mater. Chem. C, 2016, 4, 8146-8160.

(53) Yuanyuan Huang, Hui Feng, Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian*. Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatatse activity. Anal. Chem., 2016, 88, 11575-11583.

(52) Fengqi Zhou, Hui Feng, Yafen Fang, Qian Sun, Zhaosheng Qian*. Phenylsulfonic acid functionalized carbon quantum dots based on biosensor for acetylcholinesterase activity monitoring and inhibitor screening. RSC Adv., 2016, 6, 105454-105460.

(51) Yuanyuan Huang, Jin Zhou, Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian*. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots. Biosens.  Bioelectron., 2016, 86, 748-755.

(50) Hang Ao, Zhaosheng Qian (Co-first author), Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui  Feng,* Aijun Wang. A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity. Biosens.  Bioelectron., 2016, 83, 542-547.

(49) Cong Tang, Zhaosheng Qian,  Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong  Chen, Hui Feng.* A fluorometric assay for alkaline phosphatase activity  based on beta-cyclodextrin-modified carbon quantum dots through  host-guest recognition. Biosens. Bioelectron., 2016, 83, 274-280. 

(48) Yuanyuan Huang, Weidong Liu, Hui Feng,  Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong  Chen, Zhaosheng Qian.* Luminiescent nanoswitch based on  organic-phase copper nanoclusters for sensitive detection of trace  amount of water in organic solvents. Anal. Chem., 2016, 88, 7429-7434.  http://www.x-mol.com/news/3512

(47) Zhaosheng Qian, Lujing Chai,  Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* A fluorometric  assay for acetylcholinesterase activity and inhibitor screening with  carbon quantum dots. Sens. Actuat. B-Chem., 2016, 222, 879-886. 

(46) Lujing Chai, Jin Zhou, Hui Feng, Cong Tang, Yuanyuan Huang, Zhaosheng Qian.* Functionalized carbon quantum dots with dopamine for tyrosinase activity monitoring and inhibitor screening: in vitro and intracellular investigation. ACS Appl. Mater. Interfaces, 2015, 7, 23564-23574. 

(45) Lujing Chai, Jin Zhou, Hui Feng, Jingjing Lin, Zhaosheng Qian.* A reversible fluorescence nanoswitch based carbon quantum dots nanoassembly for detection of pyrophosphate ion. Sens. Actuat. B-Chem., 2015, 220, 138-145. 

(44) Zhaosheng  Qian,  Lujing Chai, Qian Zhou, Yuanyuan Huang, Cong Tang, Jianrong Chen, Hui Feng.*  Reversible fluorescent nanoswitch based on carbon quantum dots  nanoassembly for real-time acid phosphatase activity monitoring. Anal. Chem., 2015, 87, 7332-7339. 

(43) Zhaosheng  Qian,  Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* Carbon  quantum dots-based recyclable real-time fluorescence assay for alkaline  phosphatase with adenosine triphosphate as substrate. Anal. Chem., 2015, 87, 2966-2973.

(42) Zhaosheng  Qian,  Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* A fluorescent  nanosensor based on graphene quantum dots-aptamer probe and graphene  oxide for detection of lead(II) ion. Biosens. Bioelectron., 2015, 68, 225-230.  

(41) Zhaosheng  Qian,  Lujing Chai, Yuanyuan Huang, Cong Tang,  Jiajia Shen, Jianrong Chen, Hui Feng.*  A real-time fluorescent assay for the detection of alkaline phosphatase  activity based on carbon quantum dots. Biosens. Bioelectron., 2015, 68, 675-680. 

(40) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Simultaneous detection of multiple DNA targets by integrating dual-color graphene quantum dots nanoprobes and carbon nanotubes. Chem. Eur. J., 2014, 20, 16065-16069.

(39)  Zhaosheng  Qian,  Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Dual-colored graphene quantum  dots-labeled nanoprobes/graphene oxide: functional carbon materials for  respective and simultaneous detection of DNA and thrombin. Nanotechnology, 2014, 25, 415501.   

      This paper was selected as IOPselect article by the journal. The Nanotechnology Lab Talk on this work is available at http://nanotechweb.org/cws/article/lab/58679.

(38) Zhaosheng  Qian,  Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* DNA  nanosensor based on biocompatible graphene quantum dots and carbon  nanotubes. Biosens. Bioelectron., 2014, 60, 64-70. 

(37) Zhaosheng  Qian,  Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* Si-doped  carbon quantum dots: a facile and general preparation strategy,  bioimaging application, and multifunctional sensor. ACS Appl. Mater. Interfaces, 2014, 6, 6797-6805. 

(36) Zhaosheng  Qian,  Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* A  universal fluorescence sensing strategy based on biocompatible graphene  quantum dots and graphene oxide for detection of DNA. Nanoscale, 2014, 6, 5671-5674. 

(35) Xiaoyue  Shan, Lujing Chai, Juanjuan Ma, Zhaosheng Qian, Jianrong  Chen, Hui Feng.* B-doped carbon quantum dots as a sensitive fluorescence  probe for hydrogen peroxide and glucose detection. Analyst, 2014, 139, 2322-2325.   

(34)   Gangguo Zhu,* Wei Kong, Hui Feng, Zhaosheng Qian.* Synthesis of (Z)-1-thio- and (Z)-2-thio-alkenyl boronates via copper-catalyzed regiodivergent hydroboration of thioacetylenes: an experimental and theoretical study. J. Org. Chem., 2014, 79, 1786-1795.  

(33)   Jin Zhou, Xiaoyue Shan, Juanjuan Ma, Yamin  Gu, Zhaosheng Qian, Jianrong Chen, Hui Feng.* Facile  synthesis of P-doped carbon quantum dots with highly efficient  photoluminescence. RSC Adv., 2014, 4, 5465-5468.   

(32) Zhaosheng Qian,* Juanjuan Ma, Xiaoyue Shan, Hui Feng, Linxiang Shao, Jianrong Chen. Highly luminescent N-doped carbon quantum dots as an effective multifunctional fluorescence sensing platform. Chem. Eur. J., 2014, 29, 2254-2263. (Highly cited paper)

(31) Zhaosheng  Qian,  Juanjuan Ma, Xiaoyue Shan, Linxiang Shao, Jin Zhou, Jianrong Chen, Hui  Feng.* Surface functionalization of graphene quantum dots with small  organic molecules from photoluminescence modulation to bioimaging  applications: an experimental and theoretical investigation. RSC Adv., 2013, 3, 14571-14579. 

(30) Jin Zhou, Pei Lin, Juanjuan Ma, Xiaoyue Shan, Hui Feng,* Congcong Chen,  Jianrong Chen, Zhaosheng Qian.* Facile synthesis of  halogenated carbon quantum dots as an important intermediate for surface  modification. RSC Adv., 2013, 3, 9625-9628.   

(29) Zhaosheng  Qian,  Jin Zhou, Juanjuan Ma, Xiaoyue Shan, Congcong Chen, Jianrong Chen, Hui  Feng.* The visible photoluminescence mechanism of oxidized multi-walled  carbon nanotubes: an experimental and theoretical investigation. J.  Mater. Chem. C, 2013, 22, 22113-22119. 

(28)    Zhaosheng  Qian,  Juanjuan Ma, Jin Zhou, Pei Lin, Congcong Chen, Jianrong Chen, Hui Feng.*  Facile synthesis of halogenated multi-walled carbon nanotubes and their  unusual photoluminescence. J. Mater. Chem., 2012, 22, 22113-22119. 

(27)   Zhaosheng  Qian*,  Chen Wang, Gaohui Du, Jin Zhou, Congcong Chen, Juanjuan Ma, Jianrong  Chen, Hui Feng. Multicolour fluorescent graphene oxide by cutting carbon nanotubes upon oxidation. CrystEngComm, 2012, 14, 4976-4979. 

(26) Jin Zhou, Chen Wang, Zhaosheng Qian*, Congcong Chen, Juanjuan  Ma, Gaohui Du, Jianrong Chen, Hui Feng. Highly efficient fluorescent multi-walled carbon nanotubes functionalized with diamines and amides.  J. Mater. Chem., 2012, 22, 11912-11914. 

(25) Zhaosheng Qian*, Congcong chen, Jianrong Chen, Lichun Kong, Chen Wang, Jin Zhou, Hui Feng. Unusual visible luminescence of aluminium polyoxocations in aqueous solution.  Chem. Commun., 2011, 47, 12652-12654.

(24) Zhaosheng  Qian*, Jin Zhou,  Jianrong Chen, Chen Wang, Congcong Chen, Hui Feng. Nanosized N-doped graphene oxide with visible fluorescence in water for metal ions sensing. J. Mater. Chem., 2011, 21, 17635-17637. 

(23)  Jinjin Chen, Keming Fang, Yuqing Miao, Zhaosheng Qian, Jianrong Chen.* Study on adsorption of Co(II)  and Ni(II) onto mesoporous Ti-containing MCM-48. J. Nanosci.  Nanotech., 2011, 11, 6796-6803.

(22)   Zhaosheng Qian*, Chen Wang, Hui Feng, Congcong Chen, Jin Zhou, Jianrong Chen. Well dispersed single-walled carbon nanotubes with strong visible fluorescence in water for metal ions sensing. Chem. Commun., 2011, 47, 7167-7169.    

(21) Xiaoyan Jin, Wenjing Yang, Zhaosheng Qian, Yingjie Wang, Shuping Bi.* DFT study on the interaction between monomeric aluminium and chloride ion in aqueous solution. Dalton Trans., 2011, 40, 5052-5058.

(20) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Tuning the energy barrier of water exchange reactions on Al(III)  by interaction with the single-walled carbon nanotubes. Dalton Trans., 2011, 40, 4183-4189.

(19) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Theoretical investigation of formation mechanism of bipyridyl molecule on Ni(111) surface: implication for synthesis of N-doped  graphene from pyridine. Phys. Chem. Chem. Phys., 2011, 13, 6053-6058.

(18) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the substitution of F^- into Al(III) complexes in  aqueous solution. Dalton Trans., 2011, 40, 567-572.

(17) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Wenjing Yang, Shuping Bi.* Density Functional Theory Study on Aqueous Aluminum-Fluoride Complexes: Exploration of the Intrinsic Relationship between Water-Exchange Rate Constants and Structural Parameters for Monomer Aluminum Complexes. Environ. Sci. Technol., 2011, 45, 288-293.

(16) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the subsitution of F^- into Al complexes in aqueous solution. Dalton Trans., 2010, 40, 567-572.

(15) Zhaosheng Qian,* Hui Feng, Chen Wang, Jianrong Chen. Theoretical investigation of the dissociative interchange (I_d) mechanism for water exchange on magnesium(II) in  aqueous solution. Inorg. Chem. Acta, 2010, 363, 3627-3631.

(14) Wenjing Yang, Zhaosheng Qian, Bangmei Lu, Jing Zhang, Shuping Bi.* Density functional theory study and kinetic analysis of the formation mechanism of Al₃₀O₈(OH)₅₆(H₂O)₂₆¹⁸⁺  (Al₃₀) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1220-1229.

(13) Zhaosheng  Qian,  Hui Feng, Wenjing Yang, Xiaoyan Jin, Yingjie Wang, Shuping Bi.* Density  functional studies of the structural characteristics, ²⁷Al NMR chemical  shifts and water-exchange reactions of Al₃₀O₈(OH)₂₄(H₂O)₂₆¹⁸⁺  (Al₃₀) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1230-1237.

(12) Zhaosheng  Qian,  Hui Feng, Zhenjiang Zhang, Wenjing Yang, Yingjie Wang, Shuping Bi.*  Theoretical Exploration of water exchange mechanism of the polyoxocation  GaO₄Al₁₂(OH)₂₄(H₂O)₁₂⁷⁺  in aqueous solution. Geochim. Cosmochim. Acta, 2009, 73, 1588-1596.

(11) Zhaosheng  Qian,  Hui Feng, Zhejiang Zhang, Wenjing Yang, Jing Jin, Qiang Miao, Lina He,  Shuping Bi.* Theoretical investigation on the dimerization of the  deprontonated aquo ion of Al(III) in water. Dalton Trans., 2009, 521-529.

(10) Zhaosheng  Qian,  Hui Feng, Wenjing Yang, Zhejiang Zhang, Yingjie Wang, Shuping Bi.*  Theoretical investigation of dehydration of aquated Al(OH)²⁺  species in aqueous solution. Dalton Trans., 2009, 1554-1558.

(9) Zhaosheng Qian,  Hui Feng, Lina He, Wenjing Yang, Shuping Bi.* Assessment of the accuracy  of theoretical methods for calculating ²⁷Al nuclear magnetic resonance  shielding tensor of aquated aluminum species. J. Phys. Chem. A, 2009, 113, 5138-5143.

(8)  Zhaosheng Qian, Hui Feng, Wenjing Yang, Xiaoyan Jin, Shuping Bi.* Density functional study of the water exchange reaction of the polyoxocation GeO₄Al₁₂(OH)₂₄(H₂O)₁₂⁸⁺  (K-GeAl₁₂) in aqueous solution. Dalton Trans., 2009, 8013-8017.

(7)  Zhaosheng Qian,  Hui Feng, Xiaoyan jin, Wenjing Yang, Yingjie Wang, Shuping Bi.* Density  functional investigation of the water exchange reaction on the gibbsite  surface. Environ. Sci. Technol., 2009, 43, 9281-9286.

(6)  Wenjing Yang, Zhaosheng Qian, Qiang Miao, Yingjie Wang, Shuping Bi.* Density functional theory study of the aluminium(III) hydrolysis in aqueous solution. Phys. Chem.  Chem. Phys., 2009, 11, 2396-2401.

(5)  Zhaosheng Qian, Hui Feng, Wenjing Yang, Shuping Bi.* Theoretical investigation of water exchange on the nanometer-sized polyoxocation AlO₄Al₁₂(OH)₂₄(H₂O)₁₂⁷⁺  (Keggin-Al₁₃) in aqueous solution. J. Am. Chem. Soc., 2008, 130, 14402-14403.

(4)  Zhaosheng Qian,  Hui Feng, Wenjing Yang, Qiang Miao, Lina He, Shuping Bi.* Supermolecule  density functional calculations on the water exchange of aquated Al(III)  species in aqueous solution. Chem. Commun., 2008, 3930-3932.

(3)   钱兆生,  周传健,  李根,  曹玲华.*   糖基修饰的氨基酸类化合物的合成.  有机化学,  2008, 28, 467-471.

(2)   田添,  曹玲华,*  钱兆生.  N-糖基-Nˊ-酰氨基硫脲及其环合产物的合成. 有机化学,  2007, 27, 744-748.

(1)    钱兆生,  周传健,  曹玲华.*   糖基异硫氰酸酯的合成及其应用.  化学进展,  2006, 18, 429-439.

文章发表：https://orcid.org/0000-0002-2134-8300

联系方式

E-mail：qianzhaosheng@zjnu.cn

实验室：浙江师范大学11-304室

通讯地址：浙江省金华市迎宾大道688号浙江师范大学生化学院

邮　　编：321004

课题组公众号：智能分子探针荟

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2006.9 -- 2009.7
南京大学       化学       博士研究生毕业       博士学位

2009.8 -- 至今

浙江师范大学      化学与材料科学学院      教授