吕新
最后更新时间 : ..
吕新 教授，硕士生导师
浙江师范大学 化学与材料科学学院
电子邮箱：lvxin@zjnu.cn
个人简介：
吕新，男，2003年6月本科毕业于浙江大学化学系。2009年6月毕业于浙江大学化学系，获理学博士学位(导师：包伟良)。同年9月进入浙江师范大学化学与生命科学学院，任有机化学教师，讲师职务。2012年任副教授职务，硕士研究生导师。2016年8月在CSC资助下赴美新泽西州立大学化学与化学生物系进行了为期一年的访学(合作者：Daniel Seidel)。2020年12月晋升为教授。曾任有机化学学科硕士学位点负责人及有机化学学科主任。
教学方面，承担了有机化学、有机化学实验、有机合成等本科生课程，有机合成、重要有机反应及机理等研究生课程，及高等有机合成等博士生课程。曾指导或共同指导了本科生获省化学竞赛一等和三等奖；还曾指导了国创和省新苗人才计划项目。作为副主编共同参与了《有机化学实验(英汉双语版)》编著；主持有机化学精品课程建设。
科研方面，本课题组近期主要研究方向为金属有机化学和杂环合成新方法学。目前主要致力于研究催化型加成、环化与C-H键官能化等过程及相关新型串联反应的研究，以高效、便捷、经济、绿色的方式构建复杂有机分子，尤其关注于发展具潜在生物活性、医药价值和材料用途杂环分子的新合成方法。目前已发表SCI论文四十余篇。其中以通讯作者或第一作者在Chem. Commun.、Org. Lett.、Org. Chem. Front.、Chin. J. Chem.、Chem. Eur. J.、Adv. Synth. Catal.、J. Org. Chem.、Org. Biomol. Chem.和Eur. J. Org. Chem.等国际期刊上发表文章。受邀为 Adv. Sci.、Chem. Sci.、Org. Lett.、Chem. Commun.、Org. Chem. Front.、Green Chem.、Chem. Rec.、Adv. Synth. Catal.、J. Org. Chem.、Org. Biomol. Chem.、《有机化学》等多个期刊的审稿人参与审稿。受邀参与编著CRC英文书籍一章。已发表授权国家发明专利三篇。已承担国家自然科学基金项目一项，省自然科学基金三项，教育部重点实验室开放基金一项；参与国家自然科学基金和省自然科学基金各一项。此外，还积极服务地方企业，与相关公司开展合作研发新产品。
研究领域：
目前主要研究兴趣为催化型加成、环化、去芳构化与C-H键官能化等过程以及相关新型串联反应的研究，尤其关注具有潜在生物活性、医药价值或材料用途杂环分子的一锅合成。
My ORCID Web: https://orcid.org/0000-0002-5431-4529
部分论文：
46. Guodong Shen*; Kun Bi; Dehe Wang; Zhirong Zhao; Xuan Tang; Xianqiang Huang*; Xin Lv.* Condition-Controlled Divergent Selective Synthesis of (Z)-N-Vinyl and N-Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct N-Alkenylation Reactions. J. Org. Chem. 2025, 90(7): 2602–2012.
45. Guo-Dong Shen,* Zhi-Rong Zhao, Kun Bi, Yi Man, Jun-Tong Liu, Xian-Qiang Huang, Xin Lv.* Room temperature natural light promoted DMSO/O2-catalyzed N-acylation reaction of imidazoles/triazoles with cyclopropenones. Mol. Divers. 2024, doi: 10.1007/s11030-024-11039-9.
44. Yueyue Shan, Yongli Li, Chenghan He, Zeyu Hu, Xiao Xiao, Hui Mao, Xin Lv,* Liejin Zhou.* Cascade Reaction of Enyne-Amides with Sulfur-Ylides for the Synthesis of Indole-Tethered 5-Oxaspiro[2.4]hept-6-ene Derivatives. Org. Lett. 2024, 26(50): 10785-10790.
43. Zefeng Jin, Cuiying Li, Guodong Shen, Honglan Kang, Xin Lv.* One-Pot Reactions of Ynones with Isothiocyanates for Accessing 2-Aminothiophenone and Indole-Fused/Indole-Substituted Thiophenone Derivatives. Adv. Synth. Catal. 2024, 366(4): 5151-5159.
42. Guodong Shen,* Zhanjun Li, Lingyu Zhao, Ye Zhang, Yalin Zhang, Zhen Li, Xianqiang Huang,* Xin Lv.* Room-Temperature Cascade Electrophilic Addition/Cyclization/Oxidation Reactions: Divergent Selective Synthesis of Brominated 2H-Chromenes, 2H-Chromen-2-ols and 2H-Chromen-2-ones. Chem. Eur. J. 2024, 30(40): e202401011.
41. (A Review) Xin Lv,* Yuhao Yang, Liejin Zhou, Xiaojun Zeng.* Copper-Catalyzed Fluoroamide-Directed Remote C(sp3)-H Bond Functionalization Through Intramolecular Hydrogen Atom Transfer. Eur. J. Org. Chem. 2024, 27(13): e202400027.
40. (A Review) Zefeng Jin, Fangfang Zhang, Xiao Xiao, Nengzhong Wang,* Xin Lv,* Liejin Zhou.* Recent advances in N-heterocyclic carbene (NHC) catalyzed fluorination and fluoroalkylation. Org. Chem. Front. 2024,11(7): 2112 – 2133.
39. (A Review) Yahui Wang,† Zefeng Jin,† Liejin Zhou,* Xin Lv.* Recent advances in [4+4] annulation of conjugated heterodienes with 1,4-dipolar species for the synthesis of eight-membered heterocycles. Org. Biomol. Chem. 2024, 22(2): 252 – 268.
38. (A Review) Zefeng Jin, Guodong Shen, Xin Lv.* Recent Advances in Domino Synthesis of Fused Polycyclic N-Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis. Chin. J. Chem. 2023, 41(24): 3751 – 3771.
37. Xinyuan Wang,† Yueyue Shan,† Hui Mao, Xiao Xiao, Nengzhong Wang,* Xin Lv,* Liejin Zhou.* Selective N-N or N-S bond cleavage of 1-trifluoromethyl benzotriazoles enables divergent synthesis of 1,2,4-benzotriazines and benzotriazoles. Org. Chem. Front. 2023, 10(20): 5138 – 5143.
36. Mengwei You,† Yan Li,† Xin Lv,* Guodong Shen, Xiao Xiao, Liejin Zhou.* Asymmetric Synthesis of Spirofuro[2,3-b]azepine-5,3'-indoline Derivatives via Cycloisomerization/[4+3] Annulation Process under Au/N-Heterocyclic Carbene Relay Catalysis. Org. Chem. Front. 2023, 10(13): 3347 – 3352.
35. Bei Zhang, Zefeng Jin, Chaoman Huang, Yankun Zhang, Guodong Shen, Honglan Kang, Xin Lv,* Liejin Zhou.* Highly Diastereoselective One-Pot Synthesis of 4,5-Dihydrofuro[2,3-b]azocin-6-one Derivatives through Cyclization/[4 + 4] Annulation Reactions. J. Org. Chem. 2023, 88(11): 6704 – 6715.
34. Chaoman Huang,† Zefeng Jin,† Bei Zhang, Yuanyuan Zhou, Huiting Lin, Honglan Kang, Guodong Shen, Xin Lv.* One-pot synthesis of 4-(imidazol-1-yl)indole derivatives through sequential dearomatization and Ag-catalyzed cyclization/Cs2CO3-mediated addition/aromatization reaction. Org. Biomol. Chem. 2023, 21(20): 4245 – 4256.
33. Mengjiao Xu, Mengwei You, Yang Su, Boxue Lu Ruan, Ling Liu, Xin Lv, Shoulei Wang,* Hui Mao,* Liejin Zhou.* Highly efficient construction of 2,3-disubstituted indoline derivatives by [4+1] annulation of sulfur ylides and o-sulfonamido aldimines. Org. Chem. Front. 2023, 10(6): 1521 – 1526.
32. Jinhang Yu,† Xinyuan Wang,† Mengjiao Xu, Bei Zhang, Zuping Xiong, Hui Mao, Xin Lv,* Liejin Zhou.* Synthesis of α-pyrones via gold-catalyzed cycloisomerization/[2 + 1] cycloaddition/rearrangement of enyne-amides and sulfur ylides. Org. Chem. Front. 2023, 10(4): 916 – 922.
31. Jinhang Yu,† Mengjiao Xu,† Xinyuan Wang, Bei Zhang, Hui Mao, Xin Lv,* Liejin Zhou.* Catalyst-controlled cycloisomerization/[4 + 3] cycloaddition sequence to construct 2,3-furan-fused dihydroazepines and 2,3-pyrrole-fused dihydrooxepines. Org. Chem. Front. 2022, 9(7): 1850 – 1854.
30. Bei Zhang, Jinhang Yu, Xin Wu, Zeyu Chai, Guoying Zhao, Zihan Li, Honglan Kang, Xin Lv,* Liejin Zhou.* Synthesis of Furo[2,3-e][1,4]diazepin-3-one Derivatives through Tandem Cyclization/[4 + 3] Annulation Reactions. J. Org. Chem. 2022, 87(5): 3668 – 3676.
29. Haofeng Wang,† Xin Wu,† Luyu Wang,† Erfei Li, Xiaoyu Li, Tao Tong, Honglan Kang, Jianwu Xie, Guodong Shen, Xin Lv.* One-Pot Synthesis of Benzimidazo[2,1-b]thiazoline Derivatives through an Addition/Cyclization/Oxidative Coupling Reaction. J. Org. Chem. 2020, 85(18): 11934 – 11941.
28. Yifan Lin, Erfei Li, Xin Wu, Luyu Wang, Haofeng Wang, Xiaoyu Li, Honglan Kang, Liejin Zhou, Guodong Shen, Xin Lv.* One-pot synthesis of 2-azolylimidazole derivatives through a domino addition/A3 coupling/cyclization process under copper catalysis. Org. Biomol. Chem. 2020, 18(7): 1476 – 1486.
27. Erfei Li, Yifan Lin, Xin Wu, Xi Mao, Honglan Kang, Yihang Wen, Yihui Bai, Xiaoxia Wang, Xin Lv.* Regioselective single-step synthesis of 2-aminoimidazole derivatives. Tetrahedron Lett. 2019, 60(42): No. 151122.
26. Tao Tong, Xin Wu, Erfei Li, Honglan Kang, Xiaoxia Wang , Xin Lv.* One-Pot Synthesis of 4-Sulfonyliminotetrahydropyrimidin-2-one Derivatives through a Copper-Catalyzed Tandem Reaction. J. Org. Chem. 2018, 83(24): 15533 – 15540.
25. Senbao Fan, Tao Tong, Liting Fang, Jingyi Wu, Erfei Li, Honglan Kang, Xin Lv,* Xiaoxia Wang.* A facile one-pot synthesis of 2-o-cyanoaryl oxazole derivatives mediated by CuCN. Tetrahedron Lett. 2018, 59(14): 1409 – 1413.
24. Bingxin You, Mengmeng Shen, Guanqun Xie, Hui Mao, Xin Lv, Xiaoxia Wang.* Alternative Sm(II) Species-Mediated Cascade Coupling/Cyclization for the Synthesis of Oxobicyclo[3.1.0]hexane-1-ols. Org. Lett. 2018, 20(3): 530 – 533.
23. Xiaoxia Wang*, Jianyong Li, Ting Yuan, Bingxin You, Guanqun Xie, Xin Lv.* Additive Tuned Selective Synthesis of Bicyclo[3.3.0]octan-1-ols and Bicyclo[3.1.0]hexan-1-ols Mediated by AllylSmBr. J. Org. Chem. 2018, 83(16): 8984 – 8994.
22. Zhengbo Zhu,† Xin Lv,† Jason E. Anesini, Daniel Seidel.* Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation. Org. Lett. 2017, 19(23): 6424 – 6427.
21. Xi Mao, Tao Tong, Senbao Fan, Liting Fang, Jingyi Wu, Xiaoxia Wang, Honglan Kang, Xin Lv.* One-pot Synthesis of Thiazino[2,3,4-hi]indole Derivatives through a Tandem Oxidative Coupling/Heteroannulation Process. Chem. Commun. 2017, 53(34): 4718 – 4721.
20. Bingqing Xu, Bo Peng, Bili Cai, Shishi Wang, Xiaoxia Wang, Xin Lv.* Facile and Selective Synthesis of Imidazobenzimidazoles via a Copper-Catalysed Domino Addition/Cycloisomerization/ Coupling Process. Adv. Synth. Catal. 2016, 358(4): 653 – 660.
19. Jilong Gao, Bingqing Xu, Jiaqi Zhu, Yingying Shao, Lubin Chen, Jiaoyan Zhu, Xiaoxia Wang, Xin Lv.* A practical Cu(I)-catalyzed domino approach to 1,2-disubstituted indoles and its application for the assembly of indolophenanthridines. Arkivoc 2016, (3): 1-14.
18. Jiaming Tang, Bingqing Xu, Xi Mao, Hongyan Yang, Xiaoxia Wang, Xin Lv.* One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction. J. Org. Chem. 2015, 80(21): 11108 – 11114.
17. Mengmeng Shen, Yawei Tu, Guanqun Xie, Qingsheng Niu, Hui Mao, Tingting Xie, Robert A., II,Flowers, Xiaoxia Wang*, Xin Lv.* Allylsamarium Bromide-Mediated Cascade Cyclization of Homoallylic Esters. Synthesis of 2-(2-Hydroxyalkyl)cyclopropanols and 2-(2-Hydroxyethyl)bicyclo[2.1.1]hexan-1-ols. J. Org. Chem. 2015, 80(1): 52 – 61.
16. Tingting Xie, Liejin Zhou, Mengmeng Shen, Jianyong Li, Xin Lv,* Xiaoxia Wang,* Diastereoselective synthesis of cis-1,2-disubstituted cyclopropanols and cyclopent-3-enols via SmI2 mediated C-N(Bt) bond cleavage. Tetrahedron Lett. 2015, 56(26): 3982 – 3987.
15. Haiquan Liu, Jiaming Tang, Liu Jiang, Tingting Zheng, Xiaoxia Wang,* Xin Lv.* Efficient domino synthesis of benzimidazole derivatives: copper catalysis versus transition metal-free conditions. Tetrahedron Lett. 2015, 56(13): 1624 – 1630.
14. Jilong Gao, Yingying Shao, Jiaoyan Zhu, Jiaqi Zhu, Hui Mao, Xiaoxia Wang*, Xin Lv.* One-Pot Approach to 1,2-Disubstituted Indoles via Cu(II)-Catalyzed Coupling/Cyclization under Aerobic Conditions and Its Application for the Synthesis of Polycyclic Indoles. J. Org. Chem. 2014, 79(19): 9000 – 9008.
13. Jilong Gao, Jiaoyan Zhu, Lubin Chen, Yingying Shao, Jiaqi Zhu, Yijia Huang, Xiaoxia Wang,* Xin Lv.* Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction. Tetrahedron Lett. 2014, 55(22): 3367 – 3373.
12. Guodong Yuan, Haiquan Liu, Jilong Gao, Kangjian Yang, Qingsheng Niu, Hui Mao, Xiaoxia Wang, Xin Lv.* Copper-Catalyzed Domino Addition/Double Cyclization: An Approach to Polycyclic Benzimidazole Derivatives. J. Org. Chem. 2014, 79(4): 1749 – 1757.
11. Guodong Yuan, Haiquan Liu, Jilong Gao, Hongjuan Xu, Liu Jiang, Xiaoxia Wang, Xin Lv.* An efficient and facile synthesis of benzimidazo[1,2-a]benzimidazoles via copper-catalyzed domino addition/double cyclization. RSC Adv., 2014, 4(42): 21904 – 21908.
10. Qingsheng Niu, Hui Mao, Guodong Yuan, Jilong Gao, Haiquan Liu, Yawei Tu, Xiaoxia Wang,* Xin Lv.* Copper-Catalyzed Domino SN2’/Coupling Reaction: A Versatile and Facile Synthesis of Cyclic Compounds from Baylis–Hillman Acetates. Adv. Synth. Catal. 2013, 355(6): 1185 – 1192.
9. Yawei Tu, Liejin Zhou, Ruifeng Yin, Xin Lv,* Robert A. Flowers II, Kimberly A. Choquette, Huili Liu, Qingsheng Niu, Xiaoxia Wang.* Study on the coupling of acyclic esters with alkenes - the synthesis of 2-(2-hydroxyalkyl)cyclopropanols via cascade cyclization using allylsamarium bromideStudy on the coupling of acyclic esters with alkenes - the synthesis of 2-(2-hydroxyalkyl)cyclopropanols via cascade cyclization using allylsamarium bromide. Chem. Commun. 2012, 48(89): 11026 – 11028.
8. Qunxian Hu, Ziming Xia, Ling Fan, Jiening Zheng, Xiaoxia Wang,* Xin Lv.* Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy) acyl chlorides and primary amines. Arkivoc. 2012, (6): 129 – 142.
7. Ziming Xia, Kuo Wang, Jiening Zheng, Zheyong Ma, Zhanguo Jiang, Xiaoxia Wang,* Xin Lv.* Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives. Org. Biomol. Chem. 2012, 10(8): 1602 – 1611.
6. Zhi-jing Wang, Fan Yang, Xin Lv, Weiliang Bao.* Synthesis of Unsymmetrical 2,2′-Biindolyl Derivatives by a Cu-Catalyzed N-Arylation/Pd-Catalyzed Direct Arylation Sequential Process. J. Org. Chem. 2011, 76(3), 967 – 970.
5. Ziming Xia, Xin Lv,* Wencun Wang, Xiaoxia Wang.* Regioselective addition of thiophenol to alpha,beta-unsaturated N-acylbenzotriazoles. Tetrahedron Lett. 2011, 52(38): 4906 – 4910.
4. Xin Lv, Weiliang Bao.* Copper-Catalyzed Cascade Addition/Cyclization: An Efficient and Versatile Synthesis of N-Substituted 2-Heterobenzimidazoles. J. Org. Chem. 2009, 74(15): 5618 – 5621.
3. Xin Lv, Yunyun Liu, Weixing Qian, Weiliang Bao.* Copper(I)-Catalyzed One-Pot Synthesis of 2-Iminobenzo-1,3-oxathioles from ortho-Iodophenols and Isothiocyanates. Adv. Synth. Catal. 2008, 350(16): 2507 – 2512.
2. Xin Lv, Weiliang Bao.* A β-keto ester as a novel, efficient, and versatile ligand for copper(I)-catalyzed C-N, C-O, and C-S coupling reactions. J. Org. Chem. 2007, 72(10): 3863 – 3867.
1. Xin Lv, Weiliang Bao.* CuI catalyzed C–N bond forming reactions between aryl/heteroaryl bromides and imidazoles in [Bmim]BF4. Tetrahedron 2006, 62(20): 4756 – 4761.
(†These authors contributed equally)
参与编写教材：
柏一慧、朱钢国、吕新、张岩、黄鑫等编著 有机化学实验(英汉双语版)，ISBN: 978-7-03-061184-0，2019.08.
撰写书籍章节 (Book chapter):
Xin Lv, Guodong Yuan, Heterogeneous Copper-Catalyzed Synthesis of Bioactive Heterocycles (Chapter 4), in Heterogeneous Catalysis: A Versatile Tool for the Synthesis of Bioactive Heterocycles, edited by K.L. Ameta, A. Penoni, CRC Press; Taylor & Francis, pp 99-132, USA, 2014.
授权专利：
1. 一种脒类化合物的制备方法，授权中国发明专利，ZL 2014 1 0112437.4，2015.11.
2. 一种制备邻二/三卤代苯的方法，授权中国发明专利，ZL 2013 1 0533422.0，2015.11.
3. 一种2-咪唑基咪唑类化合物及其制备方法，授权中国发明专利，ZL 2019 1 1167525.3，2022.12.
近期科研项目：
1. 基于杂累积双烯参与多级串联反应合成取代杂环的研究(Y21B020022)，浙江省自然科学基金一般项目，10万，2021.01-2023.12.
2. 氮杂环卡宾(NHC)催化不对称合成含三氟甲基内酰胺，“先进催化材料”教育部重点实验室开放课题基金，1.5万，2020.01-2021.12.
3. 4,4’-二氨基三芳基甲烷类环保型弱酸性染料的研发，浙江师范大学-金华恒利康化工有限公司横向合作项目，6万，2020.01-2021.12.
4. 基于分子内加成的新型串联反应合成氮杂环化合物的研究(LY16B020003)，浙江省自然科学基金一般项目，10万，2016.01-2018.12.
5. 若干铜促新型Domino反应合成取代杂环化合物的研究(21202152)，国家自然科学基金青年科学基金项目，25万，2013.01-2015.12.
6. 铜促进的新型串联反应在合成含氮杂环化合物中的研究(Y4110044)，浙江省自然科学基金一般项目，7万，2011.01-2013.12.
邮编 :
通讯/办公地址 :
移动电话 :
邮箱 :
2004.9 -- 2009.6
浙江大学
化学
博士研究生
博士学位
有机化学专业博士研究生，导师：包伟良
1999.9 -- 2003.6
浙江大学
化学
本科
学士学位
本科生
2022.12 -- 至今
浙江师范大学 化学与材料科学学院 教授 担任教授
2020.9 -- 2022.11
浙江师范大学 化学与生命科学学院 担任教授
2012.9 -- 2020.8
浙江师范大学 化学与生命科学学院 副教授 担任副教授
2009.9 -- 2012.8
浙江师范大学 化学与生命科学学院 讲师 担任讲师 2009-09-01至2010-06-30，兼浙江师范大学行知学院学工办辅导员
催化型加成、环化与C-H键官能化等过程以及相关新型串联反应
