个人信息

姓名:     马玉勇

电话:     19914746839

邮箱:     mayuyong@zjnu.edu.cn

地址:     中国浙江省金华市迎宾大道688号, 321004

教育背景:

l  2008.9-2013.6   有机化学博士，中国科学院上海有机化学研究所导师：俞飚研究员

l  2004.9-2008.6   应用化学学士，华中科技大学，导师：聂进教授

研究经历:

l   2021.6-至今, 浙江师范大学，副教授

l   2019.2-2021.4, 中科院上海有机化学研究所，副研究员

ü  天然产物全合成

l   2018.8-2018.12, 赣南医学院，科研教师

ü  天然产物的合成及药物化学研究

l   2017.7-2018.7, 武汉药明康德新药研发有限公司，副主任级高级研究员

ü  小分子化合物的合成定制的项目管理

l   2015.7-2017.6, 美国加州大学圣地亚哥分校; 博士后导师: Seth M. Cohen教授

ü  Rpn11的小分子抑制剂的开发

l   2013.9-2015.6, 美国德州大学西南医学中心; 博士后导师: Chuo Chen教授.

ü  吡咯-咪唑二聚体生物碱的全合成以及烷烃选择性氟化研究

l   2008.9-2013.7, 中科院上海有机化学研究所；导师：俞飚研究员

ü  皂苷和寡糖类天然产物的全合成

l  2004.9-2008.6, 华中科技大学化学与化工学院；导师：聂进教授

ü  镍催化的Suzuki偶联反应

研究兴趣:

l  具有生物活性的结构新颖的天然产物的全合成

l  绿色化学转化的方法学的开发

l  抗肿瘤小分子药物的开发

发表文章:

1.         Yan Peng, Yumeng Zhang, Ruan Fang, Hao Jiang, Gongcai Lan, Yajie Liu, Zhaoyang Nie, Shou-De Zhang, Yuyong Ma, Peng Yang, Fengcan Wang, Hong-Hua Ge, Wei-Dong Zhang*, Cheng Luo*, Ang Li* and Weiwei He*, Target-identification and mechanism-of-action studies of indole terpenoid mimics reveal that proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A, bioRxiv, 2023-04. DOI:10.1101/2023.04.25.538200

2.         Ruonan Wang, Hao Xu, Arpan Banerjee, Zhongwen Cui, Yuyong Ma, William G. Whittingham, Peng Yang,* Ang Li,* Mild approach to nucleoside analogues via photoredox/Cu-catalyzed decarboxylative C-N bond formation. Total synthesis of oxetanocin A, Org. Lett. 2024, DOI:10.1021/acs.orglett.3c00914 .

3.         Shanxiang Liu, Jinxin Wang,* Yuyong Ma, Xin Cao, Ang. Li* and Weidong Zhang,* Construction of alkyl-substituted 7-norbornenones through Diels−Alder cycloaddition of electron-deficient olefins and a cyclopentadienone derivative generated in situ, Chin. Chem. Lett. 2022, 33, 2041-2043.

4.         Jiacheng Li, Yuyong Ma, Hegui Gong* and Ang Li,* Expeditious and scalable preparation of a Li−Thiele reagent for amine-based bioconjugation, Chin. Chem. Lett. 2021, 32, 700–702.

5.         Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen* and Zhigao Wang*, Novel necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis, Proc. Natl. Acad. Sci. USA 2020, 117, 6521-6530.

6.         Rubina Tuladhar，Nageswari Yarravarapu，Yuyong Ma， Chengwei Zhang， Jeremiah Herbert1,James Kim, Chuo Chen* and Lawrence Lum*，Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)，J. Biol. Chem. 2019, 294, 6273-6282.

7.         Jing Li, Yaru Zhang, Bruno Da Silva Sil Dos Santos, Feng Wang, Yuyong Ma, Christian Perez, Yanling Yang, Junmin Peng, Seth M. Cohen, Tsui-Fen Chou, Stephen T.Hilton, Raymond J. Deshaies*, Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell chem. biol., 2018, 25, 1350-1358.

8.         Chao Liu, Yuyong Ma, Chengfeng Pei, Wei Li* and Biao Yu*, A glycal approach to the synthesis of pregnane glycoside P57. Chin. J. Chem., 2018, 36, 1007-1010.

9.         Jing Li, Tanya Yakushi, Frank Parlati, Andrew L. Mackinnon, Christian Perez, Yuyong Ma, Kyle P. Carter, Sharon Colayco, Gavin Magnuson, Brock Brown, Kevin Nguyen, Stefan Vasile, Eigo Suyama, Layton H. Smith, Eduard Sergienko, Anthony B. Pinkerton, Thomas D.Y. Chung, Amy E. Palmer, Ian Pass, Sonja Hess, Seth M. Cohen, and Raymond J. Deshaies*, Capzimin is a Potent and Specific Inhibitor of Proteasome Isopeptidase Rpn11, Nat. Chem. Biol. 2017, 13, 486-496.

10.     Christian Perez, Matthieu Rouffet, Jing Li, Andy Mackinnon, Yuyong Ma, Seth M.  Cohen* and Raymond J. Deshaies*, Discovery of an Inhibitor of the Proteasome Subunit Rpn11, J. Med. Chem., 2017, 60, 1343–1361.

11.     Shenyou Nie, Xiaoping Chen, Yuyong Ma, Wei Li* and Biao Yu*, An unexpected rearrangement of pent-4-enofuranosides to cyclopentanones upon hydrogenolysis of the anomeric benzyl group, Carbohydr. Res. 2016, 432, 36-40.

12.     Zhiqiang Ma, Xiao Wang, Yuyong Ma, and Chuo Chen*, Asymmetric Synthesis of Axinellamines A and B, Angew. Chem. Int. Ed. 2016, 55, 4763-4766.

13.     Yuyong Ma, Saptarshi De and Chuo Chen*, Syntheses of Cyclic Guanidine-Containing Natural Products, Tetrahedron 2015, 71, 1145-1173.

14.     Shuyong Zhang^‡, Yuyong Ma^‡, Jing Li, Junjun Ma, Biao Yu^* and Xin Xie^*, Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc. Natl. Acad. Sci. USA 2014, 111, 14571-14576. (^‡:contribute equally)

15.     Zhiqiang Ma, Xiaolei Wang, Xiao Wang, Rodrigo A. Rodriguez, Shuanhu Gao, Xianghui Tan, Yuyong Ma, Curtis E. Moore, Arnold L. Rheingold, Phil S. Baran and Chuo Chen*, Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence. Science 2014, 346, 219-224. (Highlighted by C&EN, 2014, 92, 25)

16.     Xiao Wang, Zhqiang Ma, Xiao-Lei Wang, Saptarshi De, Yuyong Ma and Chuo Chen*, Dimeric pyrrole–imidazole alkaloids: synthetic approaches and biosynthetic hypotheses. Chem. Commun. 2014, 50, 8268-8239.

17.     Ji-Bao, Xia, Yuyong Ma, Chuo Chen*, Vanadium-catalyzed C(sp³)-H fluorination reactions. Org. Chem. Front., 2014, 1, 468-472.

18.     Yuyong Ma, Wei Li and Biao Yu*, Regio-selective Dehydrogenation on the D or E Rings of Oleanolic Acid by Pd-Promoted C-H Activation. Acta Chim. Sinica 2013, 71, 541-548.

19.     Yuyong Ma, Xin Cao,* and Biao Yu*, Synthesis of Oligosaccharide Fragments of the Rhamnogalacturonan of Nerium indicum. Carbohydr. Res. 2013, 377, 63-74.

20.     Jian Zhang, Hefang Shi, Yuyong Ma, Biao Yu*, Expeditious synthesis of saponin P57, an appetite suppressant from Hoodia plants. Chem. Commun., 2012, 48, 8679-8681.

21.     Yuyong Ma, Gaoyan Lian, Yao Li and Biao Yu*, Identification of 3,6-di-O-acetyl-1,2,4-O- orthoacetyl-a-D-glucopyranose as a direct evidence for the 4-O-acyl group participation in glycosylation. Chem. Commun., 2011, 47, 7515-7517.

22.     Yuyong Ma, Zhongzhen Li, Hefang Shi, Jian Zhang, and Biao Yu*, Assembly of Digitoxin by Gold(I)-Catalyzed Glycosidation of Glycosyl o-Alkynylbenzoates. J. Org. Chem. 2011, 76, 9748-9756.

23.     Yan Li, Weizhun Yang, Yuyong Ma, Jiansong Sun,* Lei Shan, Wei-Dong Zhang and Biao Yu*, Synthesis of Kaempferol 3-O-[2”,3” - and 2”, 4”-Di-O-(E)-p-coumaroyl]-a-L- rhamnopyranosides. Synlett 2011, 7, 915-918.

申请专利:

1. 俞飚, 谢欣, 张书永, 马玉勇, 李静和马君君. 果同尼皂苷F及其衍生物的中间体、制备方法和用途及果同尼皂苷F衍生物。2014, 申请公开号: CN103755762A

2. Deshaies, Raymond J.; Li, Jing; Cohen, Seth; Perez, Christian; Ma, Yuyong, Inhibitors of rpn11, 2017, US20170050931 A1.

3. 俞飚，党永军，裴成锋，王瑞娜，张夏衡，蒋维，马君君，李增霞，陈小平，刘超，马玉勇，徐鹏，化合物P57或其类似物用于体温降低和神经保护的用途。2020，申请公开号: CN114075260A

4. 俞飚，党永军，裴成锋，王瑞娜，张夏衡，蒋维，马君君，李增霞，陈小平，刘超，马玉勇，徐鹏，孕甾皂苷P57及其衍生物的中间体、制备方法和用途、及孕甾皂苷P57衍生物。2020，申请公开号: CN114075261A

主持或参加科研项目（课题）情况:

l  国家自然科学基金青年项目, 21901252，新型黄杨属甾体生物碱spirofornabuxine的合成研究，2020.01-2022.12，27.5万元，进行中，主持；

l  国家(863)计划课题, 00310434000281，活性海洋皂苷及类似物的合成研究，2013.01- 2017. 12，184万元，已结题，参加（排名三）；

l  国家973计划及攀登计划课题, 2012CB822102，糖链探针的生物合成研究，2012.01-2016. 12，108.2万元，已结题，参加（排名三）；

l  国家自然科学基金青年项目, 21102169，具有神经保护作用的夹竹桃多糖源寡糖分子探针库的合成研究，2012.01-2014.12，25万元，已结题，参加（排名第二）；