梁清
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一、教育背景
2007 南京大学,理论物理(软物质物理),博士,导师:马余强 教授
2001 华中师范大学,物理学,本科
二、工作经历
2010.9至今 浙江师范大学物理系,副教授,教授,硕士生导师,博士生导师
2015.3—2016.3 加拿大卡尔加里大学生物科学系,访问教授(Visiting Professor),合作者:Prof. Dr. D. Peter Tieleman
2008.9—2010.9 浙江师范大学物理系,讲师
三、研究方向
软物质理论与计算模拟
四、研究兴趣
1.生物膜内的侧向组装和微观畴结构的形成机制的分子模拟研究
2.细胞质膜与细胞骨架之间的相互作用的理论模拟研究
3.生物膜与纳米颗粒(药物颗粒等)之间的相互作用
4.机器学习在分子模拟中的应用
五、研究方法
1.粗粒化和全原子分子动力学模拟
2.机器学习
3.聚合物体系的自洽场理论
六、研究项目
1.“细胞骨架对质膜微观结构和动力学性质的影响: 以人类红细胞为例”,国家自然科学基金面上项目, 2017.1—2020.12, 已结题.
2.“膜蛋白对细胞膜的微观结构和形态的影响”,浙江省自然科学基金,2019.1-2021.12,在研.
3.“生物膜内微观畴的性质及形成机制的计算机模拟研究”, 国家自然科学基金青年基金项目, 2011.1—2013.12, 已结题.
4.“蛋白质和纳米颗粒与生物膜相互作用的计算机模拟研究”, 国家自然科学基金理论物理专款项目, 2010.1—2010.12, 已结题.
七、代表性论文
[16] Xiaoxue Qin, D. Peter Tieleman*, and Qing Liang*. Effects of cholesterol and PIP2 on interactions between glycophorin A and Band 3 in lipid bilayers. Biophys. J., 121, 2069-2077(2022). https://authors.elsevier.com/a/1f5iF_9FM6R2m
[15] Jinyu Chen, D. Peter Tieleman, and Qing Liang*. Effects of Lid Domain Structural Changes on the Interactions between Peripheral Myelin Protein 2 and a Lipid Bilayer. J. Phys. Chem. Lett. 13, 991 (2022).
[14] Xuegui Lin, Xiaojie Chen, and Qing Liang*, Coarse-Grained Simulations on Interactions between Spectrins and Phase-Separated Lipid Bilayers. Chin. Phys. B, 30, 068701 (2021). (编辑推荐)
[13] Luping Ou, Valentina Corradi, D. Peter Tieleman*, and Qing Liang*, Atomistic Simulations on Interactions between Amphiphilic Janus Nanoparticle and Lipid Bilayers: Effects of Lipid Ordering and Leaflet Asymmetry. J. Phys. Chem. B, 124, 4466 (2020).
[12] Yapan Jin, Qing Liang* and D. Peter Tieleman*, Interactions between Band 3 Anion Exchanger and Lipid Nanodomains in Ternary Lipid Bilayers: Atomistic Simulations. J. Phys. Chem. B, 124, 3054 (2020). (邀请论文)
[11] Yi-Ran Liang and Qing Liang*, Molecular simulation of interaction between charged nanoparticles and phase-separated biomembranes containing charged lipids. Acta Phys. Sin., 68, 028701 (2019).
[10] Xiaojie Chen, D. Peter Tieleman, and Qing Liang*,Modulating Interactions between Ligand-Coated Nanoparticles and Phase-Separated Lipid Bilayers by Varying the Ligand Density and the Surface Charge. Nanoscale, 10, 2481 (2018).
[9] Xiao-Jie Chen and Qing Liang*, Combined Effects of Headgroup Charge and Tail Unsaturation of Lipids on Lateral Organization and Diffusion of Lipids in Model Biomembranes. Chin. Phys. B, 26, 048701 (2017).
[8] Qing-Yan Wu and Qing Liang*, Interplay between Curvature and Lateral Organization of Lipids and Peptides/Proteins in Model Membranes. Langmuir, 30, 1116 (2014).
[7] Qing Liang*, Qing-Yan Wu, and Zhi-Yong Wang. Effect of Hydrophobic Mismatch on Domain Formation and Peptide Sorting in Multicomponent Lipid Bilayers in the Presence of Immobilized Peptides. J. Chem. Phys., 141, 074702 (2014). (封面文章)
[6] Qing Liang*. Penetration of Polymer-Grafted Nanoparticles through a Lipid Bilayer. Soft Matter, 9, 5594 (2013).
[5] Zhi-Yong Wang*, Yao-Ping Xie, Qing Liang*, Zengwei Ma, and Jianwei Wei. Looking Deeper into the Structure of Mixed Electric Double Layers near The Point of Zero Charge. J. Chem. Phys., 137, 174707 (2012).
[4] Qing Liang*, Qing-Hu Chen, and Yu-qiang Ma. Membrane-Mediated Interactions between Nanoparticles on a Substrate. J. Phys. Chem. B, 114, 5359 (2010).
[3] Qing Liang and Yu-qiang Ma. Curvature-Induced Lateral Organization in Mixed Lipid Bilayers Supported on a Corrugated Substrate. J. Phys. Chem. B, 113, 8049 (2009).
[2] Qing Liang and Yu-qiang Ma. Inclusion-Mediated Lipid Organization in Supported Membrane on a Patterned Substrate. J. Phys. Chem. B, 112, 1963 (2008).
[1] Qing Liang and Yu-qiang Ma. Organization of membrane-associated proteins in lipid bilayers. Eur. Phys. J E, 25, 129 (2008).
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南京大学
 理论物理
 博士研究生毕业
 博士学位
华中师范大学
 物理学
 本科
 学士学位
2020.1 -- 至今
浙江师范大学物理与电子信息工程学院 物理系 教授
2008.9 -- 2019.12
浙江师范大学物理与电子信息工程学院 物理系 副教授
细胞骨架与细胞膜之间的相互作用
生物膜的微观结构
纳米颗粒与细胞膜之间的相互作用