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    于海瀛

    • 教授
    • 性别 : 女
    • 毕业院校 : 德国亥姆霍兹环境研究中心(德国弗赖贝格工业大学)
    • 学历 : 博士研究生毕业
    • 学位 : 博士学位
    • 在职信息 : 在岗
    • 所在单位 : 地理与环境科学学院
    • 入职时间 : 2011-12-23
    • 学科 : 环境科学与工程
    • 联系方式 : yhy@zjnu.cn
    • Email :

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    个人简介

    个人简介

    于海瀛,教授,博士生导师(招收国际留学生),现任浙江师范大学地环学院环境科学系主任,浙江省循环经济学会理事。近年来主要从事饮用水消毒副产物、持久性有毒物质等环境污染物的形成路径、毒理效应和环境行为的分子模拟和定量结构-活性关系的研究工作。目前主持国家自然科学基金2项,浙江省自然科学基金1项,其它厅局级项目4项。截止201811月,在Environ. Sci. Technol., Chem. Res. Toxicol., Atmos. Environ.等国际著名期刊共发表学术论文40余篇,同时应邀担任Chemosphere, Environ. Pollut., Environ. Toxicol. Chem.等多个国际期刊的审稿人。2017年入选浙江省高校中青年学科带头人。

    工作学习经历

    2018.07-2019.07  加拿大阿尔伯塔大学,医学院,访问学者

    2011.11-  今,浙江师范大学,地理与环境科学学院环境科学系,讲师、副教授、教授

    2008.01-2011.11  德国亥姆霍兹环境研究中心/德国弗莱贝格工业大学,化学,博士

    2005.09-2007.12  大连理工大学,环境工程,硕士

    2001.09-2005.07  大连理工大学,环境工程,学士

    题组成员

    教师成员:马广才博士、尉小旋

    研究生:曹赏、徐晓琴、温家乐、Jephil Rwemera、陆雨晨、罗成钢、王一飞、蒋羲、陈胜男、李淼、胡珏、曹思琦、李家根

            张一凡、丁晖、贾越 (在读)

                     陈伟、袁泉、Serge Bakire、李亚、Kamaliza GraceBuyoya Jean Claude、耿利鸣、徐婷、倪君秀、祁思颖

              周阳 (已毕业)

       ◆ 主要科研项目

    1. 国家自然科学基金面上项目, “卤代乙酰胺类消毒副产物的形成路径及毒性作用的化学机制(21677133)”, 2017.01-2020.12, 主持;

    2. 国家自然科学基金青年项目, “应用量子化学方法对羟基多溴代联苯醚的pKa预测和内分泌干扰效应的机制研究(21207119)”, 2013.01-2015.12, 主持;

    3. 国家自然科学基金面上项目, “膜生物反应器中膜污染的界面热力学机制及其调控研究(51578509)”, 2017.01-2020.12, 参与;

    4. 浙江省自然科学基金一般项目, “分子解离影响HO-PBDEs与内分泌系统生物大分子作用机制的计算毒理学研究(LY16B070002)”, 2016.01-2018.12, 主持;

    5. 浙江省自然科学基金青年项目, “支持机电产品创新的技术挖掘方法研究(Y14E070005)”, 2014.1-2016.12, 参与;

    6. 浙江省留学人员科技活动择优项目, “金华市大气颗粒物中多环芳烃的污染水平调查及来源解析”, 2015.01-2016.12, 主持;

    7. 浙江省教育厅科研项目, “羟基取代的持久性有机污染物的酸碱解离常数的预测研究(Y201226156)”, 2012.10-2014.09, 主持;

    8. 金华市科技局一般项目, “金华市大气颗粒物中多环芳烃的污染水平调查及来源解析(2014-3-031)”, 2015.01-2016.12, 主持;

    9. 浙江师范大学博士启动基金项目, “多溴代联苯醚代谢产物的正辛醇-水分配系数的模型研究”, 2012.092016.08, 主持;

    10. 浙江师范大学青年教师教学改革项目, “以应用能力为导向的专业英语教学资源建设和教学模式改革”, 2012.102013.09, 主持.

    论文论著

    1. Guangcai Ma, Haiying Yu*, Xiaoqin Xu, Liming Geng, Xiaoxuan Wei, Jiale Wen, Zhiguo Wang. Molecular basis for metabolic regioselectivity and mechanism of cytochrome P450s toward carcinogenic 4-(methylnitrosamino)-(3-pyridyl)-1-butanone. Chemical Research in Toxicology, 2020, 33: 436−447.

    2. Guangcai Ma, Haiying Yu*, Cenyang Han, Yue Jia, Xiaoxuan Wei, Zhiguo Wang. Binding and Metabolism of Brominated Flame Retardant β‑1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane in Human Microsomal P450 Enzymes: Insights from Computational Studies. Chemical Research in Toxicology, 2020, https://dx.doi.org/10.1021/acs.chemrestox.0c00076.

    3. Lingmin Jin, Haiying Yu*, Liming Geng, Guangcai Ma, Xiaoxuan Wei. In silico study for inhibiting thyroid hormone sulfotransferase activity by halogenated phenolic chemicals. Ecotoxicology and Environmental Safety, 2019, 180: 146-151.

    4. Xiaoxuan Wei, Miao Li, Yifei Wang, Lingmin Jin, Guangcai Ma, Haiying Yu*. Developing predictive models for carrying ability of micro-plastics towards organic pollutants. Molecules, 2019, 24: 1784.

    5. Guangcai Ma, Haiying Yu*, Ting Xu, Xiaoxuan Wei, Jianrong Chen, Hongjun Lin, Gerrit Schüürmann. Computational insight into the activation mechanism of carcinogenic N'-Nitrosonornicotine (NNN) catalyzed by cytochrome P450. Environmental Science & Technology, 2018, 52: 11838-11847.

    6. Serge Bakire, Xinya Yang, Guangcai Ma, Xiaoxuan Wei, Haiying Yu*, Jianrong Chen, Hongjun Lin. Developing predictive models for toxicity of organic chemicals to green algae based on mode of action. Chemosphere, 2018, 190: 463-470.

    7. Huachang Hong, Huan Wu, Jiao Chen, Binbin Wu, Haiying Yu, Bin Yan, Yan Liang*. Cytotoxicity induced by iodinated haloacetamides via ROS accumulation and apoptosis in HepG-2 cells. Environmental Pollution, 2018, 242: 191-197.

    8. Meijia Zhang, Huachang Hong, Hongjun Lin*, Liguo Shen, Haiying Yu, Guangcai Ma, Jianrong Chen, Baoqiang Liao. Mechanistic insights into alginate fouling caused by calcium ions based on terahertz time-domain spectra analyses and DFT calculations. Water Research, 2018, 129, 337-346.

    9. Xiaoxuan Wei, Quan Yuan, Bakire Serge, Ting Xu, Guangcai Ma, Haiying Yu*. In silico investigation of gas/particle partitioning equilibrium of polybrominated diphenyl ethers (PBDEs). Chemosphere, 2017, 188: 110-117.

    10. Guangcai Ma, Quan Yuan, Haiying Yu*, Hongjun Lin, Jianrong Chen, Huachang Hong. Development and evaluation of predictive model for bovine serum albumin- water partition coefficients of neutral organic chemicals. Ecotoxicology and Environmental Safety, 2017, 138: 92-97.

    11. Liguo Shen, Xuena Wang, Renjie Li, Haiying Yu, Huachang Hong, Hongjun Lin*, Jianrong Chen*, Bao-Qiang Liao. Mechanistic insights into alginate fouling caused by calcium ions based on terahertz time-domain spectra analyses and DFT calculations. Journal of Colloid and Interface Science, 2017, 505: 900-909.

    12. Leihong Zhao, Fangyuan Wang, Xuexiang Weng, Renjie Li, Xiaoling Zhou, Hongjun Lin, Haiying Yu, Baoqiang Liao. Novel indicators for thermodynamic prediction of interfacial interactions related with adhesive fouling in a membrane bioreactor. Journal of Colloid and Interface Science, 2017, 487: 320-329.

    13. Quan Yuan, Guangcai Ma, Ting Xu, Bakire Serge, Haiying Yu*, Jianrong Chen, Hongjun Lin. Developing QSPR model of gas/particle partition coefficients of neutral poly-/perfluoroalkyl substances. Atmospheric Environment, 2016, 143: 270-277.

    14. Zhiqiang Fu, Jingwen Chen*, Xuehua Li, Yanan Wang, Haiying Yu. Comparison of prediction methods for octanol-air partition coefficients of diverse organic compounds. Chemosphere, 2016, 148: 118-125.

    15. Zhao Leihong, Yang Lining, Lin Hongjun*, Zhang Meijia, Haiying Yu, Liao Bao-Qiang, Wang Fangyuang, Zhou Xiaoling, Li Renjie. He Yiming,. Modeling three-dimensional surface morphology of biocake layer in a membrane bioreactor based on fractal geometry. Bioresource Technology, 2016, 222, 478-484.

    16. Huachang Hong, Qianyun Song, Asit Mazumder, Qian Luo, Jianrong Chen, Hongjun Lin, Haiying Yu, Liguo Shen, Yan Liang. Using regression models to evaluate the formation of trihalomethanes and haloacetonitriles via chlorination of source water with low SUVA values in the Yangtze River Delta region, China. Environmental Geochemistry and Health, 2016, 38: 1303-1312.

    17. Haiying Yu*, Dominik Wondrousch, Quan Yuan, Hongjun Lin, Jianrong Chen, Huachang Hong, Gerrit Schüürmann. Modeling and predicting pKa values of mono-hydroxylated polychlorinated biphenyls (HO-PCBs) and polybrominated diphenyl ethers (HO-PBDEs) by local molecular descriptors. Chemosphere, 2015, 138: 829–836.

    18. Haiying Yu*, Dominik Wondrousch, Fei Li, Jianrong Chen, Hongjun Lin, Li Ji*. In silico investigation of the thyroid hormone activity of hydroxylated polybrominated diphenyl ethers. Chemical Research in Toxicology,. 2015, 28: 1538−1545.

    19. Liguo Shen, Liang Li, Jianrong Chen, Huachang Hong, Haiying Yu, Zhengchi Hou, Hongjun Lin*, Xiaofeng Lu*. Effects of molecular weight distribution (Md) on the performances of the polyethersulfone (PES) ultrafiltration membranes. Journal of Membrane Science, 2015, 490: 220226.

    20. Huachang Hong, Lingya Qian, Yujing Xiong, Zhuoqun Xiao, Hongjun Lin, Haiying Yu. Use of multiple regression models to evaluate the formation of halonitromethane via chlorination/chloramination of water from Tai Lake and the Qiantang River, China. Chemosphere. 2015, 119: 540546.

    21. Huachang Hong, Lingya Qian, Zhuoqun Xiao, Jianqing Zhang, Jianrong Chen, Hongjun Lin, Haiying Yu, Liguo Shen, Yan Liang. Effect of nitrite on the formation of halonitromethanes during chlorination of organic matter from different origin. Journal of Hydrology. 2015, 531: 802-809.

    22. Wanyi Chen, Liping Mei, Jiuju Feng*, Tao Yuan, Aijun Wang, Haiying Yu*, Electrochemical determination of bisphenol A with a glassy carbon electrode modified with gold nanodendrites. Microchim Acta, 2015, 182:703–709.

    23. Haiying Yu, Hongjun Lin*, Meijia Zhang, Huachang Hong, Yiming He, Fangyuan Wang, Leihong Zhao. Membrane fouling in a submerged membrane bioreactor with focus on surface properties and interactions of cake sludge and bulk sludge. Bioresource Technology, 2014, 169: 213–219.

    24. Shan-Shan Li, Jie-Ning Zheng, Ai-Jun Wang, Fang-Lei Tao, Jiu-Ju Feng*, Jian-Rong Chen, Haiying Yu*. Branched platinum-on-palladium bimetallic heteronanostructures supported on reduced graphene oxide for highly efficient oxygen reduction reaction. Journal of Power Sources, 2014, 272: 1078–1085.

    25. Hongjun Lin*, Meijia Zhang, Fangyuan Wang, Yiming He, Jianrong Chen, Huachang Hong, Aijun Wang, Haiying Yu. Experimental evidence for osmotic pressure-induced fouling in a membrane bioreactor. Bioresource Technology, 2014, 158: 119126. 

    26. Fangyuan Wang, Meijia Zhang, Wei Peng, Yiming He, Hongjun Lin*, Jianrong Chen, Huachang Hong, Aijun Wang, Haiying Yu. Effects of ionic strength on membrane fouling in a membrane bioreactor. Bioresource Technology, 2014, 156: 3541.

    27. Meijia Zhang, Wei Peng, Jianrong Chen, Yiming He, Linxian Ding, Aijun Wang, Hongjun Lin*, Huachang Hong*, Ye Zhang, Haiying Yu. A new insight into membrane fouling mechanism in submerged membrane bioreactor: Osmotic pressure during cake layer filtration. Water Research, 2013, 47: 27772786.

    28. Meijia Zhang, Wei Peng, Jianrong Chen, Yiming He, Linxian Ding, Aijun Wang, Hongjun Lin*, Huachang Hong*, Ye Zhang, Haiying Yu. Author's responses to the comment by Seong-Hoon Yoon on “A new insight into membrane fouling mechanism in submerged membrane bioreactor: Osmotic pressure during cake layer filtration published in Water Research, vol. 47, pp. 27772786, 2013. Water Research, 2013, 47: 47904791.

    29. Huachang Hong, Wei Peng, Meijia Zhang, Jianrong Chen, Yiming He, Fangyuan Wang, Xuexiang Weng, Haiying Yu, Hongjun Lin*, Thermodynamic analysis of membrane fouling in a submerged membrane bioreactor and its implications. Bioresource Technology, 2013, 146: 714.

    30. Huachang Hong, Fangqu Huang, Hongjun Lin, Haiying Yu, Fangyuan Wang*, Linxian Ding. Factors affecting formation of haloacetonitriles and haloketones during chlorination/monochloramination of Jinlan Reservoir water. Water Science and Technology: Water supply, 2013, 13: 11231129.

    31. Yu Haiying, Kühne Ralph, Ebert Ralf-Uwe, Gerrit Schüürmann*. Prediction of the dissociation constant pKa of organic acids from local molecular parameters of their electronic ground state. Journal of Chemical Information and Modeling, 2011, 51(9): 2336–2344.

    32. Yu Haiying, Kühne Ralph, Ebert Ralf-Uwe, Schüürmann Gerrit*. Comparative analysis of QSAR models for predicting pKa of organic oxygen acids and nitrogen bases from molecular structure. Journal of Chemical Information and Modeling, 2010, 50: 19491960.

    33. Bing Wang, Jingwen Chen, Xuehua Li, Lin Chen, Min Zhu, Haiying Yu, Kühne Ralph, Gerrit Schüürmann*. Estimation of soil organic carbon normalized sorption coefficient (Koc) using least squares-support vector machine. QSAR & Combinatorial Science, 2009, 28(5): 561–567.

    34. Jingwen Chen*, Xuehua Li, Haiying Yu, Yanan Wang, Xianliang Qiao. Progress and perspectives of quantitative structure- activity relationships used for ecological risk assessment of toxic organic compounds. Science in China Series B: Chemistry, 2008, 51(7): 593–606.

    35. Haiying Yu, Xianliang Qiao, Ping Yang, Guanghui Ding, Jingwen Chen*. Intermolecular interactions governing the partition coefficients between particulate and air phases for typical organic pollutants. Chinese Science Bulletin, 2007, 52(3): 313–317.

    中文论文

    36. 刘聪聪, 杨新亚, 宋睿, 郭婷, 于海瀛*, 田福林. 金华市冬季大气颗粒物PM2.5 中多环芳烃的污染现状及健康风险评价. 科学通报, 2017, 62(12), 1285-1291.

    37. 于海瀛*, 陈伟, 袁泉, 陈建荣, 林红军, 洪华嫦. 有机小分子化合物解离常数pKa的预测研究进展. 科学通报, 2015, 60(14): 1261-1271.

    38. 陈伟, 陈晓旸, 于海瀛*. 磺胺二甲嘧啶在水溶液中的光化学降解. 农业环境科学学报, 2015, 35(2): 346-352.

    39. 翟竟余, 于海瀛*, 陈伟, 陈建荣, 林红军, 洪华嫦. 基于DFT方法建立多溴代联苯醚代谢产物的正辛醇-水分配系数的预测模型. 科学通报, 2014, 59(21): 2077-2083.

    40. 于海瀛, 陈伟, 梁淳淳, 袁泉, 林红军, 陈建荣*, 多溴代联苯醚及其代谢产物的正辛醇-空气分配系数的预测模型. 浙江师范大学学报(自然科学版), 2015, 38(3): 266-272.

    41. 陈景文*,李雪花,于海瀛,王亚男,乔显亮. 面向毒害有机物生态风险评价的(Q)SAR技术进展与展望. 中国科学 B, 2008, 38(6): 461-474.

    42. 于海瀛,乔显亮,杨平,丁光辉,陈景文*. 影响有机污染物在空气颗粒物与空气之间分配行为的分子间作用力. 科学通报, 2006, 51(20): 2369-2372.


    学术报告

           1. 2019.08第十届全国环境化学学术会议,中国天津,口头报告,获“优秀分会报告奖”

        2.2018.10,中国化学会环境计算化学与预测毒理学高端论坛,中国金华,口头报告

        3.2018.05,第五届全国生态毒理学研讨会,中国大连,墙报

        4. 2017.10,第九届全国环境化学学术会议,中国杭州,口头报告

        5. 2017.09,第十四届持久性有毒物质国际研讨会,日本名古屋,口头报告

        6. 2017.05,第四届全国生态毒理学研讨会,中国杭州,口头报告

        7. 2016.10,第十三届持久性有毒物质国际研讨会,德国莱比锡,口头报告

        8. 2016.04,第三届全国生态毒理学研讨会,中国无锡,口头报告

        9. 2015.10,第八届全国环境化学学术会议,中国广州,口头报告

        10. 2015. 04, 第二届全国生态毒理学研讨会,中国厦门,口头报告,获“最佳报告”奖

        11. 2014. 04,第一届全国生态毒理学研讨会,中国嘉兴,墙报

        12. 2013. 09,第七届全国环境化学学术会议,中国贵阳,墙报

        13. 2010. 05,第14届环境和健康领域QSAR年会,加拿大蒙特利尔,口头报告

        14. 2010. 09,第18QSAR欧洲年会,希腊罗德岛,口头报告

        15. 2010. 03,第5届德国化学信息学大会,德国戈斯拉尔,墙报

        16. 2009. 11,第12届化学和环境国际会议,瑞士斯德哥尔摩,墙报

       

    教学情况

    共开设过《环境化学》等八门本科生课程,目前为环境科学与工程英语班主讲《环境化学》、《环境化学实验》两门全英文课程;为环境科学与工程专业研究生(留学生)主讲《Environmental Chemistry》课程

    学生指导

        指导本科生毕业论文13篇,指导培养硕士研究生27名。指导本科生以第一作者身份发表核心期刊论文。 担任2014级环境科学(英语班)班主任,所在班级多次荣获“校学风特优班”、“校先进班集体”、“校级先进团支部”和“五四红旗团支部”等荣誉称号,继续深造率58.33%,位列全校第一。

    1.      2016.09,指导刘聪聪同学参加浙江省科技创新活动计划项目暨新苗人才计划项目。

    2.      2016.05,指导杨新亚同学参加国家级大学生创新创业训练计划。

    3.      2014.09,指导章瑜同学参加浙江省科技创新活动计划项目暨新苗人才计划项目。

    4.      2013.09,指导翟竟余同学参加浙江省科技创新活动计划项目暨新苗人才计划项目。(已结题)