个人简介：

孙洪杰，博士，副教授，硕士生导师，金华市食品安全委员会咨询专家组成员。近年来主要从事消毒副产物等新兴污染物的环境行为及健康风险等方向的研究工作（图1和图2）。目前已在环境领域Environment International, Environmental Science & Technology, Journal of Hazardous Materials, Environmental Pollution, Science of Total environment, Environmental Research, Chemosphere, Environmental toxicology and chemical 等期刊上发表SCI期刊论文60余篇，其中以第一/通讯作者身份发表SCI论文30余篇，SCI引用近3000次，H-index为29（参见https://scholar.google.com.hk/citations?user=O1gWQ_sAAAAJ&hl=zh-CN&oi=ao）。目前已申请专利5项，主持国家及其它省部级项目7项。同时应邀担任Journal of Environmental and Public Health 杂志编委及 Water Res. J. Hazard. Mater., Environ.Pollut.等多个国际期刊的审稿人。

图1. 自来水厂及家庭常见处理方式对新型消毒副产物DHNP分布及心脏毒性的影响

图 2. 新型消毒副产物3-BCZ的心脏毒性及机制的相关研究

承担科研项目情况

2017.01-2018.12，浙江省教育厅项目,金华市孝顺镇废弃电池污染场地的检测及健康风险评估,  主持

2017.04-2019.04,   金华市公益项目, “五水共治”工程后金华市水体水质的健康安全风险评估,  主持

2018.01-2020.12，国家自然科学基金项目，基于转录组学解析砷对甲状腺内分泌系统的干扰机制，主持

2019.01-2021.12,  浙江省公益项目，饮用水中消毒副产物的健康风险评价及防控, 主持

发表论文：

61. Sun Hongjie*, Liu Yingying, Wu Chunxiu, Ma Lena Q., Guan Dongxing, Hong Huachang, Yu Haiying, Lin Hongjun, Huang Xianfeng, Gao Peng, Dihalogenated nitrophenols in drinking water: Prevalence, resistance to household treatment, and cardiotoxic impact on zebrafish embryo. Eco-Environmental & Health, 2024, https://doi.org/10.1016/j.eehl.2024.02.004. 

60. Liu Yingying, Jin Xudong, Ye Yanan, Xu Zeqiong, Du Zhongkun, Hong Huachang, Yu Haiying, Lin Hongjun, Huang Xianfeng, Sun Hongjie*. 2024. Emerging disinfection byproductions 3-Bromine carbazole induces cardiac developmental toxicity via aryl hydrocar bon receptor activation in zebrafish larvae. Environmental Pollution. 346, 123609.

59. Zhu Wenting, Liu Yingying, Xuan Xiongzhi, Xu Zeqiong, Gao Peng, Jin Zhigang, Hong Huachang, Sun Hongjie*. 2024. Dihalogenated nitrophenols exposure induces developmental neurotoxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. https://doi.org/10.1016/j.envpol.2024.123609

58. Dong Mingyue, Wang Jieyu, Liu Yingying, He Qianfeng, Sunhongjie*, Xu Zeqiong, Hong Huachang, Lin Hongjun, Gao Peng, 2023. 3-Bromocarbazole-Induced Developmental Neurotoxicity and Effect Mechanisms in Zebrafish. ACS ES&T water 3, 24781-2480.

57. Dong Mingyue, Ding Yan, Liu Yingying, Xu Zeqiong, Hong Huachang, Sun Hongjie*, Huang X., Yu X. and Chen Q., 2023. Molecular insights of 2,6-dichlorobenzoquinone-induced cytotoxicity in zebrafish embryo: Activation of ROS-mediated cell cycle arrest and apoptosis. Environmental toxicology 38(3), 694-700.

56. Wang Wenqian, Chen Haohao, Zhao Wenjun, Fang Keming, Sun Hongjie*, Zhu Fengyun. 2022. Ecotoxicological assessment of spent battery extract using zebrafish embryotoxicity test: A multi-biomarker approach. Chemosphere, 287, 132120.

55. Sun Hongjie, Ding Song, Guan Dongxing, Ma Lena Q. 2022. Nrf2/keap1 pathway in countering arsenic-induced oxidative stress in mice after chronic exposure at environmentally-relevant concentrations. Chemosphere, 303, 135256.

54. Zhang Jianzhen, Ye Duo, Fu Quanyou, Chen Minjie, Lin Hongjun, Zhou Xiaoling, Deng WenjingXu Zeqiong, Sun Hongjie, Hong Huachang*, 2023. The combination of multiple linear regression and adaptive neuro-fuzzy inference system can accurately predict trihalomethane levels in tap water with fewer water quality parameters. Science of the Total Environment 896, 165269.

53. He Qianfeng, Zhang Xiaoge, Kuang Lihong, Xu Haotian, Hou Yizhong, Huang Fangqu, Xu Zeqiong, Sun Hongjie, Deng Wenjing, Lin Hongjun, Hong Huachang*, 2024. Residues of Polycyclic Aromatic Hydrocarbons in Breast Milk Collected from Jinhua (China) and the Infuence of Exercise Habit: Levels and the Potential Health Efects. Exp. Health. DOI: 10.1007/s12403-023-00560-1.

52. Zhao Wenjun, Li Xiang, Xu Ze1iong, Fang Keming, Hong Huachang, Sun Hongjie*, Guan Dong-Xing, Yu Xin-Wei. 2022. Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish. Ecotoxicology and Environmental Safety, 227, 112883

51. Wu Wenjing, Liu Yingying, Li Chunze, Zhuo Fangyu, Xu Zeqiong, Hong Huachang, Sun Hongjie*, Huang Xianfeng, Yu Xinwei. 2022. Oxidative Stress Responses and Gene Transcription of Mice under Chronic-Exposure to 2,6-Dichlorobenzoquinone. International journal of environmental reseach and public health. 19, 13801.

50. Weng Hao, Wang, Chuantian Ye, Ting Xu, Zeqiong Sun Hongjie, Lin Hongjun, Deng Wen.-Jing, Wu Fuyong and Hong Huachang*, 2022. Precursor characteristics of mono-HAAs during chlorination and cytotoxicity of mono-HAAs on HEK-293T cells. Chemosphere 301, 134689.

49. Guan, Dong-Xing., Dai Zhi-Hua, Sun Hongjie, Ma L.Q..  2022. Arsenic and selenium in the plant-soil-human ecosystem: CREST publications during 2018–2021. Critical Reviews in Environmental Science and Technology. DOI: 10.1080/10643389.2021.2010836.

48. Zhang Shengqi, Ye Chengsong, Zhao Wenjun, An Lili, Yu Xin, Zhang Lei, Sun Hongjie, Feng Mingbao. 2022. Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water. Frontiers of Environmental Science & Engineering, 16(7):1-13

47. Xu Zeqiong, Shen Jiao, Qu Yuqing, Chen Huangfei, Zhou Xiaoling, Hong Huachang, Sun Hongjie, Lin Hongjun, Deng Wenjing, Wu Fuyong. 2021. Using simple and easy water quality parameters to predict trihalomethane occurrence in tap water. Chemosphere, 286, 131586.

46. Qin Yanyan, Xu Chen, Li Wanrong, Jian  Bin, Wu Binbin, Chen Minwei, Sun Hongjie, Huachang Hong. 2021. Metal/metalloid levels in hair of Shenzhen residents and the associated influencing factors. Ecotoxicology and Environmental Safety. 220, 112375.

45. Zhang Zhiying, Pan Ting, Liu Chunrong, Shan Xiaoyun , Xu Zeqiong, Hong Huachang*, Lin Hongjun, Chen Jianrong, Sun Hongjie*. 2021. Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis. Ecotoxicology and Environmental Safety. 211, 111889.

44. Li Shiwei, Li MengYa, Sun Hongjie, Li Hong-Bo, Ma Lena Q*. 2020. Lead bioavailability in different fractions of mining-and smelting-contaminated soils based on a sequential extraction and mouse kidney model. Environmental Pollution, 114253

43. Sun Hongjie, Zhao Wen-Jun, Teng Xiao-Qiang, Shu Shui-Ping, Li Shi-Wei, Hong Hua-Chang*. Guan Dong-Xing, 2020. Antioxidant responses and pathological changes in the gill of zebrafish (Danio rerio) after chronic exposure to arsenite at its reference dose. Ecotoxicology and Environmental Safety. 200, 110743

42. 滕晓强，陆宏峰，郭心月，高畅，罗钦方，张瑜，洪华嫦，孙洪杰*，2020. 二氯苯醌对斑马鱼胚胎的发育及超氧化物歧化酶的影响. 环境科学学报  DOI: 10.13671/j.hjkxxb.2020.0074.

41. Lihong Kuang, Yizhong Hou, Fangqu Huang, Aidi Guo, Wenjing Deng, Sun Hongjie, Liguo Shen, Hongjun Lin, Huachang Hong，2020. Pesticides in human milk collected from Jinhua, China: Levels, influencing factors and health risk assessment. Ecotoxicology and Environmental Safety, 205, 111331

40. Huachang Hong, Zhiying Zhang, Aidi Guo, Liguo Shen, Sun Hongjie, Yan Liang, Fuyong Wu, Hongjun Lin. 2020. Radial basis function artificial neural network (RBF ANN) as well as the hybrid method of RBF ANN and grey relational analysis able to well predict trihalomethanes levels in tap water. Journal of Hydrology, 591, 125574

39. Kuang Lihong, Hou Yizhong, Huang Fangqu, Hong Huachang*, Sun Hongjie, Deng Wenjing, 2020. Lin Hongjun. Pesticide residues in breast milk and the associated risk assessment: A review focused on China. Science of The Total Environment 727:138412

38. Zheng Lili#, Sun Hongjie#, Wu Chouye, Wang Y, Zhang Y, Ma Guangcai, Lin Hongjun, Chen Jianrong, Hong Huachang*. 2020. Precursors for brominated haloacetic acids during chlorination and a new useful indicator for bromine substitution factor. Science of the Total Environment. 698, 134250

37. Sun Hongjie*, Zhang Jingying, Wang Qiang, Zhu engao, Chen Wenrong, Lin Hongjun, Chen Jianrong, Hong Huachang, 2019. Environmentally relevant concentrations of arsenite induces developmental toxicity and oxidative responses in the early life stage of zebrafish. Environmental Pollution 254, 113022.

36. Zhang Yu, Sun Hongjie*, Zhang Jing-Ying, Ndayambaje Emmanuel, Lin Hongjun, Chen Jianrong, Hong Huachang, 2019. Chronic exposure to dichloroacetamide induces biochemical and histopathological changes in the gills of zebrafish, Environmental Toxicology, 34(7):781-787 (Front cover).

35. Sun Hongjie, Zhang Yu, Zhang Jing-Ying, Lin Hongjun, Chen Jianrong, Hong Huachang*. 2019. The toxicity of 2,6-dichlorobenzoquinone on the early life stage of zebrafish: a survey on the endpoints at developmental toxicity, oxidative stress, genotoxicity and cytotoxicity. Environmental Pollution. 245，719-724

34. Sun Hongjie, Song Xuhui, Ye Ting, Hu Junbiao, Hong Huachang*, Chen Jianrong, Lin Hongjun, Yu Haiying. 2018. Formation of disinfection by-products during chlorination of organic matter from phoenix tree leaves and Chlorella vulgaris. Environmental Pollution, 243(B): 1887-1893.

33. Dong Wen-Qi, Sun Hongjie*, Zhang Yu, Lin Hong-Jun, Chen Jian-Rong, Hong Hua-Chang. 2018. Impact on growth, oxidative stress, and apoptosis-related gene transcription of zebrafish after exposure to low concentrations of arsenite, Chemosphere, 211: 648-652.

32. Sun Hongjie, Zhang yu, Ndayambaje Emmanuel, Dong Wen-Qi, Lin Hong-Jun, Chen Jian-Rong, Hong Hua-Chang* 2018. The effect of short-term exposure to low Ph/aluminum on the ion regulation, related ATPase activities and haematological parameters of juvenile common carp. Fresenius Environmental Bulletin, 27: 3318-3325.

31. 金玲敏，陆雨晨，李其闯，刘子瑞，董文琪，洪华嫦，孙洪杰*. 2018, 二氯乙酰胺对斑马鱼不同组织的毒性效应. 环境科学与技术. 41: 20-23.

30. Li, Shiwei, Sun Hongjie, Wang Gang, Cui Xinyi, Juhasz A.L., Li Hongbo*, and Ma Lena Q.*. 2017. Lead relative bioavailability in soils based on different endpoints of mouse model. Journal of Hazardous Materials. 2017. 326: 94-100.

29. Sun Hongjie, Li, Shiwei, Li, C.; Wang, W. Q.; Li, H. B.*; Ma, L. Q., 2017. Thyrotoxicity of arsenate and arsenite on juvenile mice at organism, subcellular, and gene levels under low exposure. Chemosphere. 186, 580-587.

28. 宋倩云，宁萍，孙洪杰，林红军，陈建荣，洪华嫦*. 2017. 长三角部分水源水氯化消毒后卤乙酸形成的多元回归模型研究. 环境科学学报. 6:2048-2054

27. Hong Huachang*, Yan Xiaoqing*, Song Xuhui, Qin Yanyan, Sun Hongjie, Lin Hongjun, Chen Jianrong, Liang Yan. 2017. Bromine incorporation into five DBP classes upon chlorination of water with extremely low SUVA values. Science of The Total Environment, 590-591: 720-728.

26. Li, Hongbo, Li Jie, Zhao Di, Li Chao, Wang Xuejiao, Sun Hongjie, Juhasz A.L., and Ma Lena Q.*. 2017. Arsenic relative bioavailability in rice using a mouse arsenic urinary excretion bioassay and its application to assess human health risk. Environmental Science & Technology. 51(8): 4689-4696.

25. Xiang Ping, Liu Rongyan, Sun Hongjie, Yang Yunwen, Cui Xinyi*, and Ma Lena Q.* 2017. Effects of novel brominated flame retardant TBPH and its metabolite TBMEHP to human vascular endothelial cells: Implication for human health risks. Environmental Research. 156: 834-842.

24. Li, Shiwei, Liu Xue, Sun Hongjie, Li Mengya, Zhao Di, Luo Jun, Li Hongbo*, and Ma Lena Q. 2017. Effect of phosphate amendment on relative bioavailability and bioaccessibility of lead and arsenic in contaminated soils. Journal of Hazardous Materials. 339: 256-263.

23. Sun Hongjie, P. Xiang, J. Luo, H. C. Hong, H. J. Lin, H. B. Li*, and L. Q. Ma*. 2016. Mechanisms of arsenic disruption on gonadal, adrenal and thyroid endocrine systems in humans: A review. Environment International 95: 61-68.

22. Sun Hongjie, P. Xiang, M. H. Tang, L. Sun, and L. Q. Ma*. 2016. Arsenic impacted the development, thyroid hormone and gene transcription of thyroid hormone receptors in bighead carp larvae (Hypophthalmichthys nobilis). Journal of Hazardous Materials. 303: 76-82.

21. Li Jie, Li Chao, Sun Hongjie, A. L. Juhasz, Luo Jun, Li Hongbo*, and L. Q. Ma*. 2016. Arsenic relative bioavailability in contaminated soils: Comparison of animal models, dosing schemes and biological endpoints. Environmental Science & Technology. 50(1): 453-461.

20. Xiang Ping, Liu Rongyan, Sun Hongjie, Han Yonghe, He Ruiwen, Cui Xinyi, and Ma Lena Q.*. 2016. Molecular mechanisms of dust-induced toxicity in human corneal epithelial cells: Water and organic extract of office and house dust. Environment International. 2016. 92-93: 348-356.

19. Xiang Ping, He Ruiwen, Han Yonghe, Sun Hongjie, Cui Xinyi, and Ma Lena Q.*. 2016. Mechanisms of housedust-induced toxicity in primary human corneal epithelial cells: Oxidative stress, pro-inflammatory response and mitochondrial dysfunction. Environment International. 89-90: 30-37.

18. Li, Shiwei, Sun Hongjie, Li Hongbo, Luo Jun*, and Ma Lena Q.*. 2016. Accessment of cadmium bioaccessibility to predict its bioavailability in contaminated soils. Environment International. 94: 600-606.

17. Li, Chao, Sun Hongjie, Juhasz, A. L. Cui Xinyi*, and Ma Lena. Q.*. 2016. Prediction of DDTr relative bioavailability in historically-contaminated soils using a Tenax-improved physiologically-based extraction test (TI-PBET). Environmental Science & Technology. 50: 1118-1125.

16. Sun Hongjie, H. B. Li, P. Xiang, X. Zhang, and L. Q. Ma*. 2015. Short-term exposure of arsenite disrupted thyroid endocrine system and  altered gene transcription in the HPT axis in Zebrafish. Environmental Pollution. 205: 145-152.

15. Sun Hongjie, W. Wang, J. Li, and Z. Yang*. 2014. Growth, oxidative stress responses, and gene transcription of juvenile bighead carp (Hypophthalmichthys nobilis) under chronic-term exposure of ammonia. Environmental Toxicology and Chemistry. 33: 1726-1731 (SCI 3区top, IF2015=2.763).

14. Sun Hongjie, B. Rathinasabapathi, B. Wu, J. Luo, L. P. Pu, and L. Q. Ma*. 2014. Arsenic and selenium toxicity and their interactive effects in humans. Environment International. 69: 148-158.

13. Ren Jinghua, Sun Hongjie, Wang Songfeng, and Ma Lena Q.*. 2014. Interactive effects of mercury and arsenic on their uptake, speciation and toxicity in rice plant. Chemosphere. 117: 737-744.

12. Ren Jinghua, Ma Lena Q.*, Sun Hongjie, Cai Fei, and Luo Jun*. 2014. Antimony uptake, translocation and speciation in rice plants exposed to antimonite and antimonate. Science of the Total Environment. 475: 83-89

11. 高亚峰, 孙洪杰*. 2014. 氨氮对鱼类的危害. 河北渔业. 8: 62-67.

10. Chen, Yafen*, Sun Hong-Jie, W. Yang, and Z. Yang. Response of crucian carp carassius auratus newly-hatched larvae exposed to mixtures of microcystin and ammonia: growth and antioxidant defenses. Fresenius Environmental Bulletin. 2013. 22: 1253-1258

9. Chen Yafen, Li Jiajia, Sun Hongjie, and Yang Zhou*. 2013. Dose-dependent effect of un-ionized ammonia on hatching success of fertilized eggs of silver carp Hypophthalmichthys molitrix and bighead carp Hypophthalmichthys nobilis. Journal of Freshwater Ecology. 28: 39-46.

8. Sun Hongjie, W. Wang, L. Geng, Y. Chen, and Z. Yang*. 2013. In situ studies on growth, oxidative stress responses, and gene expression of juvenile bighead carp (Hypophthalmichthys nobilis) to eutrophic lake water dominated by cyanobacterial blooms. Chemosphere. 93: 421-427.

7. Sun Hongjie, K. Lü, E. J. A. Minter, Y. Chen, Z Yang*, and D. J. S. Montagnes. 2012. Combined effects of ammonia and microcystin on survival, growth, antioxidant responses, and lipid peroxidation of bighead carp Hypophthalmythys nobilis larvae. Journal of Hazardous Materials. 221-222: 213-219.

6. Sun Hongjie, L. Tang, J. Li, and Z. Yang*. 2012. Responses of crucian carp Carassius auratus to long-term exposure to nitrite and low dissolved oxygen levels. Biochemical Systematics and Ecology. 2012. 44: 224-232.

5. Chen Yafen*, Sun Hongjie, Yang Wei, and Yang Zhou. 2012. Incubation and oxidative stress of grass carp (Ctenopharyngodon idella) embryos exposed to different un-ionized ammonia levels. Journal of Freshwater Ecology. 27: 143-150.

4. Sun Hongjie, Yang wei, Chen Yafen, and Yang Zhou*. 2011. Effect of purified microcystin on oxidative stress of silver carp Hypophthalmichthys molitrix larvae under different ammonia concentrations. Biochemical Systematics and Ecology. 39: 536-543.

3. Chen Yafen*, Sun Hongjie, Yang Wei, and Yang Zhou. 2011. Oxidative stress responses of grass carp Ctenopharyngodon idella larvae exposed to purified microcystin under different ammonia concentrations. Fresenius Environmental Bulletin. 20: 2869-2874.

2. Yang Wei, Sun Hongjie, Xiang Fuhui, and Yang Zhou*. 2011. Response to long-term ammonia exposure by juvenile crucian carp Carassius auratus feeding, growth, and antioxidant defenses. Journal of Freshwater Ecology. 26: 653-570.

1. Yang Wei, Xiang Fuhui, Sun Hongjie, Chen Yafen, Minter E., and Yang Zhou*. 2010. Changes in the selected hematological parameters and gill Na+/K+ ATPase activity of juvenile crucian carp Carassius auratus during elevated ammonia exposure and the post-exposure recovery. Biochemical Systematics and Ecology. 38: 557-562.

学生指导

指导陈依雯等学生参加2023年浙江省大学生环境生态科技创新大赛，并获得一等奖；

指导沈佳乐等学生参加2022年浙江省大学生环境生态科技创新大赛，获二、三等奖各一项；

指导余昱瑶等学生参加2022年全国大学生节能减排社会实践大赛，并获得三等奖。

教学情况

为本科生主讲课程有《环境生态学》、《环境毒理学》及《环境毒理学实验》。