基本资料钱兆生，博士，副教授，硕士生导师，浙江省杰出青年基金获得者，分析学科主任。2009.6月南京大学化学化工学院化学专业获理学博士学位，博士论文曾获2011年度全国优秀博士学位论文提名论文。2009.8起在浙江师范大学分析化学学科开展分析化学教学工作和相关科研工作。2013-2014年由国家公派到美国华盛顿大学做访问研究一年。目前从事于纳米材料的光致发光性能及其传感应用研究和基于小分子有机化合物的分子开关的设计与合成。目前主持一项国家自然科学基金面上项目和浙江省杰出青年基金，主持完成国家自然科学基金青年基金和一项浙江省自然科学基金，参与两项国家自然科学基金面上项目和一项浙江省自然科学基金，主持完成一项横向项目；已在JACS、ChemComm、Anal. Chem.、Biosens. Bioelectron.、Chem. Eur. J.、Nanoscale、J. Mater. Chem.、SNB、ACS Applied Mater. Interface等国际著名学术期刊上发表六十余篇论文; 高被引论文有3篇，总引用次数超过1300次，被邀为JACS、Anal. Chem.、Biosens. Bioelectron.、SNB、Nanoscale、ACA、Talanta、Carbon等刊物的审稿人。目前指导研究生七名，已毕业研究生六名，指导研究生曾获研究生国家奖学金、耿儿奖学金、学校科学创新一等奖和二等奖、浙江省优秀研究生学位论文培育基金、校级优秀研究生学位论文培育基金等。 主要研究方向1. 新型发光纳米材料的合成和性质研究，包括碳量子点、金银铜纳米簇及无机量子点等；基于新型纳米荧光材料，设计与构建可逆的发光纳米开关，用于磷酸酶、糖苷酶等水解酶活性定量检测方法的建立2. 基于有机小分子化合物的分子开关的设计、合成及分析检测应用，着重研究基于聚集诱导发光体系的磷光分子开关的设计与构建，并将其用于酪氨酸酶、硝基还原酶等氧化还原酶活性定量检测方法的建立，探索小分子光学探针在细胞和生物体内实时荧光示踪功能 科研项目(1)功能化碳量子点荧光纳米开关的设计、构建及在生物酶检测中的应用 国家自然科学基金面上项目 2017-2020 主持(2)聚集诱导磷光金属纳米簇的设计合成及基于时间门控发光技术的生物传感和成像应用 浙江省杰出青年基金 2018-2021 主持(3)铝形态水交换反应在碳基纳米管作用下的动力学研究 国家自然科学基金青年科学基金 2011 -2013 主持(4)采用密度泛函理论研究钙在多聚铝团簇形成中的作用 高露洁公司横向项目2012 -2013 主持(5)基于碳纳米管和碳量子点的纳米靶向药物输送体系的构建及生物学评价浙江省自然科学基金2013-2016 主持(6)多层薄膜型拉曼器件的设计、构建及远程调控国家自然科学基金面上项目 2012 – 2016 参与(7)石墨烯-介孔氧化物对有机化合物的吸附、催化及分析检测国家自然科学基金面上项目 2013 – 2017 参与(8)碳量子点/氧化石墨烯荧光检测平台的构建及其对生物标记物DNA分子的检测 浙江省自然科学基金2013-2016 参与(9)基于光诱导电子转移机制的可控纳米探针的构建及应用浙江省自然科学基金2017-2019 参与 发表学术论文(68) Hui Feng, Zhaosheng Qian*. Functional Carbon Quantum Dots: A Versatile Platform for Chemosensing and Biosensing.Chem. Rec., 2018, DOI: 10.10002/tcr/201700055. (Invited Review)(67) Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan, Zhaosheng Qian*. Redox-controlled fluorescent nanoswitch based on reversible disulfide and its application in butyrylcholinesterase activity assay.Anal.Chem., 2018, 90, 1643-1651.(66) Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng.* Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening. Sens. Actuat. B-Chem, 2018, 255, 22-28.(65) Meizhi Zhao, Hui Feng, Xiaoxiao Zhang, Hang Ao, Zhaosheng Qian*. Bonding-Induced Emission of Silyl-Protected Copper Nanoclusters for Luminescence Turn-on Detection of Trace Water in Organic Solvents.Analyst, 2017, 142, 4613-4617. (Cover Paper)(64) Hang Ao, Hui Feng, Mengting Zhao, Meizhi Zhao, Jianrong Chen, Zhaosheng Qian.* Redox-triggered bonding-induced emission of thiol-functionalized gold nanoclusters for luminescence turn-on detection of molecular oxygen. ACS Sens., 2017, 2, 1692-1699.(63) Meizhi Zhao, Zhaosheng Qian(Coauthors), Mengting Zhong, Zhentian Chen, Hang Ao, Hui Feng.* Fabrication of stable and luminescent copper nanocluster-based AIE particles and their application in β-galactosidase activity assay. ACS Appl. Mater. Interfaces, 2017, 9, 32887-32895.(62) Meizhi Zhao, Hui Feng, Jiaonan Han, Hang Ao, Zhaosheng Qian*. Multi-stimuli responsive copper nanoclusters with bright red luminescence for quantifying acid phosphatase via redox-controlled luminescence switch. Anal Chim. Acta, 2017, 984, 202-210.(61) Yuanyuan Huang, Hui Feng, Weidong Liu, Shasha Zhang, Cong Tang, Jianrong Chen, Zhaosheng Qian,* Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for beta-galactosidase activity monitoring, J. Mater. Chem. B, 2017, 5, 5120-5127.(60) Cong Tang, Hui Feng, Yuanyuan Huang, Zhaosheng Qian*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity. Anal. Chem. 2017, 89, 4994-5002. (59) Qian Sun, Siying Fang, Yafen Fang, Zhaosheng Qian, Hui Feng*. Fluorometric Detection of Cholestrol Based on beta-Cyclodextrin Functionalized Carbon Quantum Dots via Competitive Host-Guest Recognition.Talanta, 2017,167, 513-519.(58) Ao Hang, Hui Feng, Xiaolu Huang, Meizhi Zhao, Zhaosheng Qian*. A Reversible Fluorescence Nanoswitch Based on Dynamic Covalent B-O Bonds Using Functional Carbon Quantum Dots and Its Application for α-Glucosidase Activity Monitoring. J. Mater. Chem. C, 2017, 5, 2826-2832.(57) Cong Tang, Jin Zhou, Zhaosheng Qian(Co-first author), Yanyan Ma, Yuanyuan Huang, Hui Feng*. A Universal Fluorometric Assay Strategy for Glycosidases Based on Functional Carbon Quantum Dots: ß-Galactosidase Activity Detection in vitro and in Living Cells. J. Mater. Chem. B, 2017, 5, 1971-1979.(56) Cong Tang, Zhaosheng Qian(Co-first author), Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng*. A Fluorometric and Real-time Assay for α-Glucosidase Activity Through Supramolecular Self-assembly and Its Application for Inhibitor Screening. Sens. Actuat. B-Chem, 2017, 245, 282-289.(55) Hong Huang, Hua Li, Jiuju Feng, Hui Feng, Aijun Wang,* Zhaosheng Qian.* One-pot green synthesis of highly fluorescent glutathione-stabilized copper nanoclusters for Fe3+ sensing. Sens. Actuat. B Chem. 2017, 241, 292-297. 2015 – 2016(54) Aijun Wang, Hua Li, Hong Huang, Zhaosheng Qian, Jiuju Feng*. Fluorescent graphene-like carbon nitrides: synthesis, properties and applications, J. Mater. Chem. C, 2016, 4, 8146-8160.(53) Yuanyuan Huang, Hui Feng, Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian*. Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatatse activity. Anal. Chem., 2016, 88, 11575-11583.(52) Fengqi Zhou, Hui Feng, Yafen Fang, Qian Sun, Zhaosheng Qian*. Phenylsulfonic acid functionalized carbon quantum dots based on biosensor for acetylcholinesterase activity monitoring and inhibitor screening. RSC Adv., 2016, 6, 105454-105460.(51) Yuanyuan Huang, Jin Zhou, Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian*. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots. Biosens. Bioelectron., 2016, 86, 748-755.(50) Hang Ao, Zhaosheng Qian (Co-first author), Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui Feng,* Aijun Wang. A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity. Biosens. Bioelectron., 2016, 83, 542-547.(49) Cong Tang, Zhaosheng Qian, Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong Chen, Hui Feng.* A fluorometric assay for alkaline phosphatase activity based on beta-cyclodextrin-modified carbon quantum dots through host-guest recognition. Biosens. Bioelectron., 2016, 83, 274-280. (48) Yuanyuan Huang, Weidong Liu, Hui Feng, Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian.* Luminiescent nanoswitch based on organic-phase copper nanoclusters for sensitive detection of trace amount of water in organic solvents. Anal. Chem., 2016, 88, 7429-7434. http://www.x-mol.com/news/3512(47) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* A fluorometric assay for acetylcholinesterase activity and inhibitor screening with carbon quantum dots. Sens. Actuators B: Chemical, 2016, 222, 879-886. (46) Lujing Chai, Jin Zhou, Hui Feng, Cong Tang, Yuanyuan Huang, Zhaosheng Qian.* Functionalized carbon quantum dots with dopamine for tyrosinase activity monitoring and inhibitor screening: in vitro and intracellular investigation. ACS Appl. Mater. Interfaces, 2015, 7, 23564-23574. (45) Lujing Chai, Jin Zhou, Hui Feng, Jingjing Lin, Zhaosheng Qian.* A reversible fluorescence nanoswitch based carbon quantum dots nanoassembly for detection of pyrophosphate ion. Sens. Actuators B: Chemical, 2015, 220, 138-145. (44) Zhaosheng Qian, Lujing Chai, Qian Zhou, Yuanyuan Huang, Cong Tang, Jianrong Chen, Hui Feng.* Reversible fluorescent nanoswitch based on carbon quantum dots nanoassembly for real-time acid phosphatase activity monitoring. Anal. Chem., 2015, 87, 7332-7339. (43) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* Carbon quantum dots-based recyclable real-time fluorescence assay for alkaline phosphatase with adenosine triphosphate as substrate. Anal. Chem., 2015, 87, 2966-2973.(42) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* A fluorescent nanosensor based on graphene quantum dots-aptamer probe and graphene oxide for detection of lead(II) ion. Biosens. Bioelectron., 2015, 68, 225-230. (Highly cited paper)(41) Zhaosheng Qian, Lujing Chai, Yuanyuan Huang, Cong Tang, Jiajia Shen, Jianrong Chen, Hui Feng.* A real-time fluorescent assay for the detection of alkaline phosphatase activity based on carbon quantum dots. Biosens. Bioelectron., 2015, 68, 675-680. (40) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Simultaneous detection of multiple DNA targets by integrating dual-color graphene quantum dots nanoprobes and carbon nanotubes. Chem. Eur. J., 2014, 20, 16065-16069.(39) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Dual-colored graphene quantum dots-labeled nanoprobes/graphene oxide: functional carbon materials for respective and simultaneous detection of DNA and thrombin. Nanotechnology, 2014, 25, 415501. This paper was selected as IOPselect article by the journal. The Nanotechnology Lab Talk on this work is available at http://nanotechweb.org/cws/article/lab/58679.(38) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* DNA nanosensor based on biocompatible graphene quantum dots and carbon nanotubes. Biosens. Bioelectron., 2014, 60, 64-70. (37) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* Si-doped carbon quantum dots: a facile and general preparation strategy, bioimaging application, and multifunctional sensor. ACS Appl. Mater. & Interfaces, 2014, 6, 6797-6805. (Highly cited paper)(36) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* A universal fluorescence sensing strategy based on biocompatible graphene quantum dots and graphene oxide for detection of DNA. Nanoscale, 2014, 6, 5671-5674. (35) Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Zhaosheng Qian, Jianrong Chen, Hui Feng.* B-doped carbon quantum dots as a sensitive fluorescence probe for hydrogen peroxide and glucose detection. Analyst, 2014, 139, 2322-2325. (34) Gangguo Zhu,* Wei Kong, Hui Feng, Zhaosheng Qian.* Synthesis of (Z)-1-thio- and (Z)-2-thio-alkenyl boronates via copper-catalyzed regiodivergent hydroboration of thioacetylenes: an experimental and theoretical study. J. Org. Chem., 2014, 79, 1786-1795.(33) Jin Zhou, Xiaoyue Shan, Juanjuan Ma, Yamin Gu, Zhaosheng Qian, Jianrong Chen, Hui Feng.* Facile synthesis of P-doped carbon quantum dots with highly efficient photoluminescence. RSC Adv., 2014, 4, 5465-5468. (32) Zhaosheng Qian,* Juanjuan Ma, Xiaoyue Shan, Hui Feng, Linxiang Shao, Jianrong Chen. Highly luminescent N-doped carbon quantum dots as an effective multifunctional fluorescence sensing platform. Chem. Eur. J., 2014, 29, 2254-2263. (Highly cited paper)(31) Zhaosheng Qian, Juanjuan Ma, Xiaoyue Shan, Linxiang Shao, Jin Zhou, Jianrong Chen, Hui Feng.* Surface functionalization of graphene quantum dots with small organic molecules from photoluminescence modulation to bioimaging applications: an experimental and theoretical investigation. RSC Adv., 2013, 3, 14571-14579. (30) Jin Zhou, Pei Lin, Juanjuan Ma, Xiaoyue Shan, Hui Feng,* Congcong Chen, Jianrong Chen, Zhaosheng Qian.* Facile synthesis of halogenated carbon quantum dots as an important intermediate for surface modification. RSC Adv., 2013, 3, 9625-9628. (29) Zhaosheng Qian, Jin Zhou, Juanjuan Ma, Xiaoyue Shan, Congcong Chen, Jianrong Chen, Hui Feng.* The visible photoluminescence mechanism of oxidized multi-walled carbon nanotubes: an experimental and theoretical investigation. J. Mater. Chem. C, 2013, 22, 22113-22119. (28)Zhaosheng Qian, Juanjuan Ma, Jin Zhou, Pei Lin, Congcong Chen, Jianrong Chen, Hui Feng.* Facile synthesis of halogenated multi-walled carbon nanotubes and their unusual photoluminescence. J. Mater. Chem., 2012, 22, 22113-22119. (27)Zhaosheng Qian*, Chen Wang, Gaohui Du, Jin Zhou, Congcong Chen, Juanjuan Ma, Jianrong Chen, Hui Feng. Multicolour fluorescent graphene oxide by cutting carbon nanotubes upon oxidation. CrystEngComm, 2012, 14, 4976-4979. (26) Jin Zhou, Chen Wang, Zhaosheng Qian*, Congcong Chen, Juanjuan Ma, Gaohui Du, Jianrong Chen, Hui Feng. Highly efficient fluorescent multi-walled carbon nanotubes functionalized with diamines and amides. J. Mater. Chem., 2012, 22, 11912-11914.(25) Zhaosheng Qian*, Congcong chen, Jianrong Chen, Lichun Kong, Chen Wang, Jin Zhou, Hui Feng. Unusual visible luminescence of aluminium polyoxocations in aqueous solution.Chem. Commun., 2011, 47, 12652-12654.(24) Zhaosheng Qian*, Jin Zhou, Jianrong Chen, Chen Wang, Congcong Chen, Hui Feng. Nanosized N-doped graphene oxide with visible fluorescence in water for metal ions sensing. J. Mater. Chem., 2011, 21, 17635-17637.(23) Jinjin Chen, Keming Fang, Yuqing Miao, Zhaosheng Qian, Jianrong Chen.* Study on adsorption of Co(II) and Ni(II) onto mesoporous Ti-containing MCM-48. J. Nanosci. Nanotech., 2011, 11, 6796-6803.(22) Zhaosheng Qian*, Chen Wang, Hui Feng, Congcong Chen, Jin Zhou, Jianrong Chen. Well dispersed single-walled carbon nanotubes with strong visible fluorescence in water for metal ions sensing. Chem. Commun., 2011, 47, 7167-7169.(21) Xiaoyan Jin, Wenjing Yang, Zhaosheng Qian, Yingjie Wang, Shuping Bi.* DFT study on the interaction between monomeric aluminium and chloride ion in aqueous solution. Dalton Trans., 2011, 40, 5052-5058.(20) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Tuning the energy barrier of water exchange reactions on Al(III) by interaction with the single-walled carbon nanotubes. Dalton Trans., 2011, 40, 4183-4189.(19) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Theoretical investigation of formation mechanism of bipyridyl molecule on Ni(111) surface: implication for synthesis of N-doped graphene from pyridine. Phys. Chem. Chem. Phys., 2011, 13, 6053-6058.(18) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the substitution of F- into Al(III) complexes in aqueous solution. Dalton Trans., 2011, 40, 567-572.(17) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Wenjing Yang, Shuping Bi.* Density Functional Theory Study on Aqueous Aluminum-Fluoride Complexes: Exploration of the Intrinsic Relationship between Water-Exchange Rate Constants and Structural Parameters for Monomer Aluminum Complexes. Environ. Sci. Technol., 2011, 45, 288-293.(16) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the subsitution of F- into Al complexes in aqueous solution. Dalton Trans., 2010, 40, 567-572.(15) Zhaosheng Qian,* Hui Feng, Chen Wang, Jianrong Chen. Theoretical investigation of the dissociative interchange (Id) mechanism for water exchange on magnesium(II) in aqueous solution. Inorg. Chem. Acta, 2010, 363, 3627-3631.(14) Wenjing Yang, Zhaosheng Qian, Bangmei Lu, Jing Zhang, Shuping Bi.* Density functional theory study and kinetic analysis of the formation mechanism of Al30O8(OH)56(H2O)2618+ (Al30) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1220-1229.(13) Zhaosheng Qian, Hui Feng, Wenjing Yang, Xiaoyan Jin, Yingjie Wang, Shuping Bi.* Density functional studies of the structural characteristics, 27Al NMR chemical shifts and water-exchange reactions of Al30O8(OH)24(H2O)2618+ (Al30) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1230-1237.(12) Zhaosheng Qian, Hui Feng, Zhenjiang Zhang, Wenjing Yang, Yingjie Wang, Shuping Bi.* Theoretical Exploration of water exchange mechanism of the polyoxocation GaO4Al12(OH)24(H2O)127+ in aqueous solution. Geochim. Cosmochim. Acta, 2009, 73, 1588-1596.(11) Zhaosheng Qian, Hui Feng, Zhejiang Zhang, Wenjing Yang, Jing Jin, Qiang Miao, Lina He, Shuping Bi.* Theoretical investigation on the dimerization of the deprontonated aquo ion of Al(III) in water. Dalton Trans., 2009, 521-529.(10) Zhaosheng Qian, Hui Feng, Wenjing Yang, Zhejiang Zhang, Yingjie Wang, Shuping Bi.* Theoretical investigation of dehydration of aquated Al(OH)2+ species in aqueous solution. Dalton Trans., 2009, 1554-1558.(9) Zhaosheng Qian, Hui Feng, Lina He, Wenjing Yang, Shuping Bi.* Assessment of the accuracy of theoretical methods for calculating 27Al nuclear magnetic resonance shielding tensor of aquated aluminum species. J. Phys. Chem. A, 2009, 113, 5138-5143.(8) Zhaosheng Qian, Hui Feng, Wenjing Yang, Xiaoyan Jin, Shuping Bi.* Density functional study of the water exchange reaction of the polyoxocation GeO4Al12(OH)24(H2O)128+ (K-GeAl12) in aqueous solution. Dalton Trans., 2009, 8013-8017.(7) Zhaosheng Qian, Hui Feng, Xiaoyan jin, Wenjing Yang, Yingjie Wang, Shuping Bi.* Density functional investigation of the water exchange reaction on the gibbsite surface. Environ. Sci. Technol., 2009, 43, 9281-9286.(6) Wenjing Yang, Zhaosheng Qian, Qiang Miao, Yingjie Wang, Shuping Bi.* Density functional theory study of the aluminium(III) hydrolysis in aqueous solution. Phys. Chem. Chem. Phys., 2009, 11, 2396-2401.(5) Zhaosheng Qian, Hui Feng, Wenjing Yang, Shuping Bi.* Theoretical investigation of water exchange on the nanometer-sized polyoxocation AlO4Al12(OH)24(H2O)127+ (Keggin-Al13) in aqueous solution. J. Am. Chem. Soc., 2008, 130, 14402-14403.(4) Zhaosheng Qian, Hui Feng, Wenjing Yang, Qiang Miao, Lina He, Shuping Bi.* Supermolecule density functional calculations on the water exchange of aquated Al(III) species in aqueous solution. Chem. Commun., 2008, 3930-3932.(3) 钱兆生, 周传健, 李根, 曹玲华.* 糖基修饰的氨基酸类化合物的合成. 有机化学, 2008, 28, 467-471.(2) 田添, 曹玲华,* 钱兆生. N-糖基-Nˊ-酰氨基硫脲及其环合产物的合成. 有机化学, 2007, 27, 744-748.(1) 钱兆生, 周传健, 曹玲华.* 糖基异硫氰酸酯的合成及其应用. 化学进展, 2006, 18, 429-439. 联系方式E-mail：qianzhaosheng@zjnu.cn实验室：浙江师范大学11-304室通讯地址：浙江省金华市迎宾大道688号浙江师范大学生化学院邮　　编：321004