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基本信息Personal Information
教授 博士生导师 硕士生导师
性别 : 男
毕业院校 : 华东师范大学
学历 : 博士研究生毕业
学位 : 博士学位
在职信息 : 在岗
所在单位 : 化学与材料科学学院
入职时间 : 2019年09月09日
学科 : 化学
办公地点 : 11幢419
Email :
教师其他联系方式Other Contact Information
通讯/办公地址 :
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个人简介Personal Profile
工作经历
2022.12-至今 教授，浙江师范大学
2022.12-2023.11 访问学者，日本仙台Tohoku University (Naohiko Yoshikai)
2021.12-2022.6 访问学者，中科院上海有机所 (刘国生研究员)
2019.10-至今 “双龙学者”特聘教授, 浙江师范大学
2016.10-2019.10 博士后，新加坡南洋理工大学 (Yonggui Robin Chi)
2011.8-2012.7 研究助理，中科院上海有机所 (刘国生研究员)
2007.8-2008.7 中学老师，诸暨市同山镇中心学校
教育经历
2012.9-2016.6 博士 华东师范大学 (张俊良教授)
2008.9-2011.6 硕士 浙江师范大学 (王小霞教授)
2003.9-2007.6 本科 浙江师范大学
主持项目
烯炔酰胺的重排和开环反应研究22471241，国家自然科学基金面上项目，主持
叔膦和氮杂环卡宾协同催化环化反应研究21901233，国家自然科学基金青年项目，主持
氮杂环卡宾和铜协同催化的不对称反应研究 Y22B023840，浙江省自然科学基金一般项目，主持
浙江省领军型创新创业团队项目，参与
独立建组之后发表论文：
2024
1) Y. Shan,† Y. Li,† C. He,† Z. Hu, X. Xiao, H. Mao, X. Lv,* L. Zhou.* Cascade Reaction of Enyne-Amides with Sulfur.Yides for the Svnthesis ofindoe-Tethered 5-Oxaspiro 2.4 hept-6-ene Derivatives. Org. Lett. 2024, 26, https://doi.org/10.1021/acs.orglett.4c03800
2) †Y. Lan, †T. Bian, F. Zhang, Y. Liang, L. Zhou,* Z. Zhang* Pd-Catalyzed Selective Defluoroalkylation of Trifluoromethylarenes. Synlett DOI: 10.1055/a-2460-8168
3) †Wang, J.; †Zhou, Q.; Zhou, L.; Zhang, Z.* Pd-Catalyzed Difluoroalkylation of Alkenes Using Chlorodifluoroalkanes. ACS Catal. 2024, 14, 18499–18506
4) †Zhou, Q.;† Wang, J.; Bian, T.; Liang, Y.; Yan, W.; Zhou, L.; Zhang, Z.* Pd-Catalyzed 1,4-Difluoromethylative Functionalization of 1,3-Dienes Using Freon-22. Org. Lett. 2024, 26, 9091–9096
5) †Zhang, F.; †Zhang, G.; Zhou, Q.; Bian, T.; Zhou, L.; Zhang, Z.* Hybrid Palladium-Catalyzed Intramolecular Carboamination of Conjugated Dienes: Synthesis of Functionalized Pyrrolidines via Selective Trifluoromethylarene Defluorination. J. Org. Chem. 2024, 89, 7790–7794
6) †Liang, Y.; †Bian, T.; Yadav, K.; Zhou, Q.; Zhou, L.; Sun, R.; Zhang, Z.* Selective 1,4-syn-Carboamination of Cyclic 1,3-Dienes via Hybrid Palladium Catalysis . ACS Cent. Sci. 2024, 10, 1191–1200
7) S. Chen,‡ P. Liang,‡ Y. Cai, L. Zhou,* S. Wang.* Substrate-directed divergent annulations of sulfur ylides: synthesis of functionalized bispirocyclopentane and bispirocyclopropane derivatives. Org. Biomol. Chem. 2024, 22, 2197-2202
8) Y. Wang,† Z. Jin,† L. Zhou,* X. Lv.* Recent advances in [4+4] annulation of conjugated heterodienes with 1,4-dipolar species for the synthesis of eight-membered heterocycles. Org. Biomol. Chem. 2024, 22(2): 252 – 268.
9) Z. Jin, F. Zhang, X. Xiao, N. Wang,* X. Lv,* L. Zhou.* Recent advances in N-heterocyclic carbene (NHC) catalyzed fluorination and fluoroalkylation. Org. Chem. Front. 2024,11(7): 2112 – 2133.
10) X. Lv,* Y. Yang, L. Zhou, X. Zeng.* Copper-Catalyzed Fluoroamide-Directed Remote C(sp3)-H Bond Functionalization Through Intramolecular Hydrogen Atom Transfer. Eur. J. Org. Chem. 2024, 27(13): e202400027.
2023
1) X. Wang, Y. Shan, H. Mao, X. Xiao, N. Wang,* X. Lv,* L. Zhou,* Selective N-N or N-S bond cleavage of 1-trifluoromethyl benzotriazoles enables divergent synthesis of 1,2,4-benzotriazines and benzotriazoles. Org. Chem. Front. 2023, 10, 5138.
2) L. Zhou,* Copper/phosphine-catalyzed asymmetric radical reactions. Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis. https://doi.org/10.1016/B978-0-323-85225-8.00006-X
3) M. You, Y. Li, X. Lv,* G. Shen, X. Xiao, L. Zhou,* Asymmetric Synthesis of Spirofuro[2,3-b]azepine-5,3’-indoline Derivatives via Cycloisomerization/[4+3] Annulation Process under Au/N-Heterocyclic Carbene Relay Catalysis. Org. Chem. Front. 2023, 10, https://doi.org/10.1039/D3QO00539A
4) B. Zhang, Z. Jin, C. Huang, Y. Zhang, G. Shen, H. Kang, X. Lv,* L. Zhou,* Highly Diastereoselective One-Pot Synthesis of 4,5-Dihydrofuro[2,3-b]azocin-6-one Derivatives through Cyclization/[4 + 4] Annulation Reactions. J. Org. Chem. 2023, https://doi.org/10.1021/acs.joc.3c00003
5) L. Zhou, Z. Zhang,* Recent Advances of Unactivated C(sp3)-H Functionalization via Radical Pathway. https://doi.org/10.1002/9783527834242.chf0169
6) S. Wei, G. Zhang, Y. Wang, M. You, Y. Wang, L. Zhou,* Z. Zhang,* Modular Synthesis of Unsaturated Azaheterocycles via Copper Catalyzed Multicomponent Cascade Reaction. iScience, 2023, DOI: 10.1016/j.isci.2023.106137.
7) W. Xu, L. Zhou,* T. XU,* Deoxygenative Alkylboration of Aldehydes to Synthesize Versatile Secondary α, α-Dialkyl Boronates. Synlett 2023, DOI: 10.1055/a-2014-2936.
8) M. Xu, M. You, Y. Su, B. Lu Ruan, L. Liu, X. Lv, S. Wang,* H. Mao,* L. Zhou,* Highly Efficient Construction of 2,3-Disubstituted Indoline Derivatives through [4+1] Annulation of Sulfur Ylides and o-Sulfonamido Aldimines. Org. Chem. Front. 2023, 10, 10.1039/D2QO01966C.
9) J. Yu, X. Wang, M. Xu, B. Zhang, Z. Xiong, H. Mao, X. Lv,* L. Zhou,* Synthesis of α-pyrones via gold-catalyzed cycloisomerization/[2 + 1] cycloaddition/rearrangement of enyne-amides and sulfur ylides. Org. Chem. Front. 2023, 10, DOI: 10.1039/d2qo01388f.
2022
10) X. Wang, J. Yu, M. Xu, H. Mao, Y. Shan, X. Lv, L. Zhou,* Metal-Free [5 + 1] Cycloaddition–Aromatization of Benzotriazoles and Sulfur Ylides to Construct 1,2,4-Benzotriazines. Org. Lett. 2022, 24, 5896.
11) J. Yu, M. Xu, X. Wang, B. Zhang, H. Mao, X. Lv,* L. Zhou,* Catalyst-controlled cycloisomerization/[4+3] cycloaddition sequence to construct 2,3-furan-fused dihydroazepines and 2,3-pyrrole-fused dihydrooxepines. Org. Chem. Front. 2022, 9, 1850.
12) B. Zhang, J. Yu, X. Wu, Z. Chai, G. Zhao, Z. Li, H. Kang, X. Lv,* L. Zhou,* Synthesis of Furo[2,3- e ][1,4]diazepin-3-one Derivatives through Tandem Cyclization/[4 + 3] Annulation Reactions. J. Org. Chem. 2022, 87, 3668.
13) Z. Lei, S. Wei, L. Zhou,* Z. Zhang,* S. E. Lopezb, W. R. Dolbier, Jr.* Photocatalytic Difluoromethylarylation of Unactivated Alkenes via a (Hetero)aryl Neophyl-like Radical Migration. Org. Biomol. Chem. 2022, 20, 5712.
14) S. Wei, S. Le, Z. Lei, L. Zhou,* Z. Zhang,* W. R. Dolbier, Jr,* Difluoromethylarylation of α, β- Unsaturated Amides via a Photocatalytic Radical Smiles Rearrangement. Org. Biomol. Chem. 2022, 20, 2064.
15) Y. Feng,* L. Zhou,* Z. Cao. 过渡金属催化氟代烯烃参与的交叉偶联反应进展. Chin. J. Appl. Chem. 2022, 39, 749.
2021
16) L. Zhou, S. Wei, Z. Lei, G. Zhu, Z. Zhang. Transition‐Metal‐Free α Csp3‐H Cyanation of Sulfonamides. Chem. Eur. J. 2021, 27, 7103.
17) L. Zhou, L. Liu. Highly enantioselective tandem cycloisomerization/Diels–Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals: dual catalysis with platinum and amines. Chem. Commun. 2021, 57, 5690.
2020
18) C. Mou, L. Zhou, R. Song, H. Cai, L. Hao, Y. R. Chi. Carbene-Catalyzed Reaction of Indolyl Methylenemalononitriles and Enals for Access to Complex Tetrahydrocarbazoles. Org. Lett. 2020, 22, 2542.
19) M. You, T. Bian, L. Zhou, Z. Zhang,* Accessing Aryldifluoromethyl Derivatives via Alkenes Insertion of Benzylic C-F Bonds. Synlett 2023, DOI: 10.1055/a-2068-7065
20) H. Zhang, B. Xu, L. Zhou, Z. Zhang,* J. Zhang,* Polymer-supported chiral palladium-based complexes as efficient heterogeneous catalysts for asymmetric reductive Heck reaction. Green Synth. Catal. 2023, DOI: 10.1016/j.gresc.2023.04.002
21) J. Wang, Y. Wang, Y. Liang, L. Zhou, L. Liu, Z. Zhang, Late-Stage Modification of Trifluoromethyl Aromatic Drugs via Selective C-F Bond Insertion of Olefins. Angew. Chem. Int. Ed. 2022, 61, 10.1002/anie.202215062.
22) X. Yang, L. Wei, Y. Wu, L. Zhou, X. Zhang, Y. R. Chi, Atroposelective Access to 1,3‐Oxazepine‐Containing Bridged Biaryls via Carbene‐Catalyzed Desymmetrization of Imines. Angew. Chem. Int. Ed. 2022, 61, e202211977.
23) Z. Ye, Z. Lei, X. Ye, L. Zhou, Y. Wang, Z. Yuan, F. Gao, R. Britton, Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process. J. Org. Chem. 2022, 87, 765.
24) Y. Lin, E. Li, X. Wu, L. Wang, H. Wang, X. Li, H. Kang, L. Zhou, G. Shen, X. Lv, One-pot synthesis of 2-azolylimidazole derivatives through a domino addition/A3 coupling/cyclization process under copper catalysis. Org. Biomol. Chem. 2020, 18, 1476.
25) 陈旭，周列锦，王利民，韩建伟，精细化工的先驱：Sir William Henry Perkin与合成染料. Univ. Chem. 2023, 38, doi: 10.3866/PKU.DXHX202207124
26) X. Yang, Y. Xie, J. Xu, Shichao Ren, B. Mondal, L. Zhou, W. Tian, X. Zhang, L. Hao, Z. Jin, Y. R. Chi. Carbene‐Catalyzed Activation of Remote Nitrogen Atoms of (Benz)imidazole‐Derived Aldimines for Enantioselective Synthesis of Heterocycles. Angew. Chem. Int. Ed. 2021, 60, 7906.
27) X. Yang, P. K. Majhi, H. Chai, B. Liu, J. Sun, T. Liu, Y. Liu, L. Zhou, J. Xu, J. Liu, D. Wang, Y. Zhao, Z. Jin, Y. R. Chi. Carbene-Catalyzed Enantioselective Aldol Reaction: Post-AldolStereochemistry Control and Formation of Quaternary Stereogenic Centers. Angew. Chem. Int. Ed. 2021, 60, 159.
独立建组之前发表论文
1) L. Zhou,† X. Wu,† X. Yang, C. Mou, R. Song, S. Yu, H. Chai, L. Pan, Z. Jin, Y. R. Chi, Gold and Carbene Relay Catalytic Enantioselective Cycloisomerization/Cyclization Reactions of Ynamides and Enals. Angew. Chem. Int. Ed. 2020, 59, 1557. (L. Zhou,† X. Wu,† contributed equally)
2) X. Wu,† L. Zhou,† R. Maiti, C. Mou, L. Pan, Y. R. Chi, Sulfinate and Carbene Co-catalyzed Rauhut-Currier Reaction for Enantioselective Access to Azepino[1,2-a]indole. Angew. Chem. Int. Ed. 2019, 58, 477. (X. Wu,† L. Zhou,†contributed equally)
3) L. Zhou, B. Xu, J. Zhang, Metal-free Dehydrogenative Diels-Alder Reactions of 2-Methyl, 3-Aryl-methyl-indoles and Dienophiles：A Rapid Access to Tetrahydrocarbazoles, Carbazoles and Heteroacenes. Angew. Chem. Int. Ed. 2015, 54, 9092.
4) L. Zhou, M. Zhang, W. Li, J. Zhang, Furan-Based o-Quinodimethanes by Gold-Catalyzed Dehydrogenative Heterocyclization of 2-(1-Alkynyl)-2-alken-1-ones: A Modular Entry to 2, 3-Furan Fused Carbocycles. Angew. Chem. Int. Ed. 2014, 53, 6542.
5) S. Zhuo, T. Zhu, L. Zhou, C. Mou, H.Chai, Y. Lu, L. Pan, Z. Jin, Y. R. Chi, Access to All-Carbon Spirocycles through a Carbene and Thiourea Cocatalytic Desymmetrization Cascade Reaction, Angew. Chem. Int. Ed. 2019, 58, 1784.
6) X. Yang, G. Luo, L. Zhou, B. Liu, X. Zhang, H. Gao, Z. Jin, Y. R. Chi, Enantioselective Indole N–H Functionalization Enabled by Addition of Carbene Catalyst to Indole Aldehyde at Remote Site. ACS Catal. 2019, 9, 10971.
7) W. Li, L. Zhou, J. Zhang, Recent Progress in Dehydrogenative Diels-Alder Reaction. Chem. Eur. J. 2016, 22, 1558.
8) L. Zhou, X. Lv, H. Mao, X. Wang. Selective Substitution Reactions of Methoxycarbonylamino-1-(1-benzotriazolyl)alkanes with Active Methylene Compounds. J. Heterocyclic Chem.2011, 48, 434.
9) H. Mao, B. You, L. Zhou, T. Xie, Y. Wen, X. Lv, X. Wang, SmI2-mediated reductive cyclization of β-arylthio ketones: a facile and diastereoselective synthesis of thiochroman derivatives. Org. Biomol. Chem.,2017, 15, 6157.
10) T. Xie, Liejin Zhou, M. Shen, J. Li, X. Lv, X. Wang, Diastereoselective synthesis of cis-1,2-disubstituted cyclopropanols and cyclopent-3- enols via SmI2 mediated C–N(Bt) bond cleavage. Tetrahedron Lett. 2015, 56, 3982.
11) R. Yin, L. Zhou, H. Liu, H. Mao, X. Lv, X. Wang, Reactivity of AllylSmBr/HMPA: Facile Synthesis of 3-Aryl-1,2,4-benzotriazines.Chin. J. Chem.2013, 31, 143.
12) Y. Tu, L. Zhou, R. Yin, X. Lv, R. A. Flowers II, K. A. Choquette, H. Liu, Q. Niu, X. Wang, Study on the coupling of acyclic esters with alkenes the synthesis of 2-(2-hydroxyalkyl) -cyclopropanols via cascade cyclization using allylsamarium bromide. Chem. Commun.2012, 48, 11026.