研究方向：

（1）物理有机化学。以实验与计算结合的手段探究反应机理与重要试剂的构效关系，揭示重要有机反应中影响反应性与选择性的关键因素，为理性设计反应与催化剂提供理论依据。具体研究内容包括：a) 重要试剂与催化剂的酸度研究；b) 物理有机导向的新型试剂/催化剂的设计。

（2）计算有机化学。采用高精度量子化学计算方法深入探索有机催化反应机理，剖析控制反应选择性起源的因素，为合理解释实验现象和理性设计新反应与新催化剂提供理论支持。具体研究内容包括：a) 有机催化不对称反应的机理及对映选择性起源的理论计算研究；b) 有机反应中特殊溶剂效应的理论计算研究。

（3）自由基化学。采用可见光催化等策略，发展新型自由基氟化、氟烷基化、环化新反应。

发表论文：

(1). Jiayan Qiu, Xuemei Zhang, Hanliang Zheng*, Gangguo Zhu*.  Photocatalytic Phosphine-Mediated Deoxygenative [3 + 2] Cycloaddition of α,β-Unsaturated Carbonyls and Alkenes. J. Am. Chem. Soc. 2025, 147, 19004–19012.

(2). Hanliang Zheng*, Liu Cai, Xiaoyu Lai, Muhammet Uyanik, Kazuaki Ishihara, Xiao-Song Xue*. Unraveling Alcohol Additive Effects on Hypervalent Iodine(III)-Catalyzed Asymmetric Phenolic Dearomatization: Ligand Substitution and Low-Barrier Hydrogen Bonds. ACS Catal. 2025, 15, 370–380. 

(3). Jian Zhang*, Jia-Yi Su, Hanliang Zheng*, Hao Li, Wei-Ping Deng*. In(OTf)₃-Catalyzed (3 + 3) Dipolar Cyclization of Bicyclo[1.1.0]butanes with N-Nucleophilic 1,3-Dipoles: Access to 2,3-Diazabicyclo[3.1.1]heptanes, 2,3-Diazabicyclo[3.1.1]heptenes, and Enantiopure 2-Azabicyclo[3.1.1]heptanes. ACS Catal. 2024, 14, 17837–17849. 

(4). Yuwei Hong, Jiayan Qiu, Zhenzhen Wu, Sangxuan Xu, Hanliang Zheng,* Gangguo Zhu.* Tetrafluoroisopropylation of alkenes and alkynes enabled by photocatalytic consecutive difluoromethylation with CF₂HSO₂Na. Nat Commun. 2024, 15, 5685.

(5). Yulu Zhou, Zhenzhen Wu, Jinming Xu, Zuxiao Zhang, Hanliang Zheng,* Gangguo Zhu.* Fluorine-Effect-Enabled Photocatalytic 4-Exo-Trig Cyclization Cascade to Access Fluoroalkylated Cyclobutanes. Angew. Chem. Int. Ed. 2024, e202405678. 

(6). Jiawei Xu, Wei Lin, Hanliang Zheng,*  Xin Li.* Enantioselective Synthesis of Axially Chiral Diaryl Ethers through Chiral Phosphoric Acid-Catalyzed Desymmetric Acylation with Azlactones. ACS Catal. 2024, 14, 6667–6673.

(7). Ji Li, Yulu Zhou, Jinmin Luo, Huiqin Chen, Hangkai Qi, Hanliang Zheng*, Gangguo Zhu*. Controllable Synthesis of Cyclopenta[b]indolines via Photocatalytic Fluoroalkylative Radical Cyclization Cascade of Ynamides. Org. Lett. 2024, 26, 4643–4647.

(8). Zhenyu Gu, Rong Jia, Tianqing Zeng, Hanliang Zheng*, Gangguo Zhu*. Photocatalytic [3+2] Cycloaddition of Alkyl/aryl Iodides and Internal Alkynes by Merging Halogen and Hydrogen Atom Transfer.  Chin. J. Chem. 2024, 42, 2329—2334. 

(9). Zheng, H^#.; Cai, L.^#; Pan, M.; Uyanik, M.; Ishihara, K.; Xue, X.-S*. Catalyst-Substrate Helical Character Matching Determines the Enantioselectivity in the Ishihara-Type Iodoarenes Catalyzed Asymmetric Kita-Dearomative Spirolactonization. J. Am. Chem. Soc. 2023, 145,  7301–7312;

(10). Su, J.; Guo, W.; Liu, Y.; Kong, L.; Zheng, H.*; Zhu, G.* Cu-catalyzed cascade difluoroalkylation/5-endo cyclization/β-fluorine cleavage of ynones. Chem. Commun. 2023, 59, 1821-1824;

(11). Le, S.; Bai, Y.; Qiu, J.; Zhang, Z.; Zheng, H.*; Zhu, G.* Access to cyclopentenones via copper-catalyzed 5-endo trifluoromethylcarbocyclization of ynones. Org. Chem. Front. 2022, 9, 4670-4675;

(12). Zhu, H.^#; Zheng, H.^#; Zhang, J.^#; Feng, J.; Kong, L.; Zhang, F.; Xue, X.-S.*; Zhu, G.* Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols. Chem. Sci. 2021, 12, 11420-11426; 

(13). Zheng, H.; Li, Z.; Jing, J.; Xue, X.-S.; Cheng, J.-P. The Acidities of Nucleophilic Monofluoromethylation Reagents: An Anomalous alpha-Fluorine Effect. Angew. Chem. Int. Ed. 2021, 60, 9401-9406; 

(14). Zheng, H.; Xue, X.-S. Recent Computational Studies on Mechanisms of Hypervalent Iodine(III)-Promoted Dearomatization of Phenols. Curr. Org. Chem. 2020, 24, 2106-2117; 

(15). Shu, C.^#; Feng, J.^#; Zheng, H.^#; Cheng, C.; Yuan, Z.; Zhang, Z.; Xue, X.-S.; Zhu, G. Internal Alkyne-Directed Fluorination of Unactivated C(sp³)-H Bonds. Org. Lett. 2020, 22, 9398-9403;

(16). Zheng, H.; Sang, Y.; Houk, K. N.; Xue, X.-S.; Cheng, J.-P. Mechanism and Origins of Enantioselectivities in Spirobiindane-Based Hypervalent Iodine(III)-Induced Asymmetric Dearomatizing Spirolactonizations. J. Am. Chem. Soc. 2019, 141, 16046-16056.